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Total 102 results found since Jan 2013.
Doxorubicin resistance in breast cancer is mediated via the activation of FABP5/PPAR γ and CaMKII signaling pathway
Breast cancer is the most prevalent malignancy among women. Doxorubicin (Dox) resistance was one of the major obstacles to improving the clinical outcome of breast cancer patients. The purpose of this study was to investigate the relationship between the FABP signaling pathway and Dox resistance in breast cancer. The resistance property of MCF-7/ADR cells was evaluated employing CCK-8, Western blot (WB), and confocal microscopy techniques. The glycolipid metabolic properties of MCF-7 and MCF-7/ADR cells were identified using transmission electron microscopy, PAS, and Oil Red O staining. FABP5 and CaMKII expression levels w...
Source: Frontiers in Pharmacology - July 19, 2023 Category: Drugs & Pharmacology Source Type: research
S100A9 promotes glycolytic activity in HER2-positive breast cancer to induce immunosuppression in the tumour microenvironment
CONCLUSIONS: S100A9 overexpression upregulated the glycolysis activity of tumour cells through the c-Myc-related pathway, suppressing lymphocyte infiltration in the tumour stroma, affecting the efficacy of immune regulation and long-term survival of patients.PMID:36755606 | PMC:PMC9900376 | DOI:10.1016/j.heliyon.2023.e13294
Source: Cancer Control - February 9, 2023 Category: Cancer & Oncology Authors: Jia-Qi Yuan Shou-Man Wang Lei Guo Source Type: research
Impact of silencing eEF2K expression on the malignant properties of chordoma
CONCLUSION: Our findings indicate that the loss of eEF2K expression in chordoma cell lines results in the reduction of metastatic capacity.PMID:36652154 | DOI:10.1007/s11033-023-08257-z
Source: Mol Biol Cell - January 18, 2023 Category: Molecular Biology Authors: Esra Aydemir Emre Can T üysüz Ömer Faruk Bayrak Didem Tecimel Ay şen Aslı Hızlı-Deniz Fikrettin Şahin Source Type: research
Cancers, Vol. 14, Pages 5838: Suppression of Calcium Entry Modulates the Expression of TR & beta;1 and Runx2 in Thyroid Cancer Cells, Two Transcription Factors That Regulate Invasion, Proliferation and Thyroid-Specific Protein Levels
In conclusion, we show that TRβ1 is downregulated in thyroid cancer cells and that restoration of its expression can reverse the cancer cell phenotype towards a normal thyroid cell phenotype.
Source: Cancers - November 26, 2022 Category: Cancer & Oncology Authors: Muhammad Yasir Asghar Taru Knuutinen Emilia Holm Tommy Nordstr öm Van Dien Nguyen You Zhou Kid T örnquist Tags: Article Source Type: research
Cancers, Vol. 14, Pages 5363: Electroporation in Head-and-Neck Cancer: An Innovative Approach with Immunotherapy and Nanotechnology Combination
i
Marco Benazzo
Squamous cell carcinoma is the most common malignancy that arises in the head-and-neck district. Traditional treatment could be insufficient in case of recurrent and/or metastatic cancers; for this reason, more selective and enhanced treatments are in evaluation in preclinical and clinical trials to increase in situ concentration of chemotherapy drugs promoting a selectively antineoplastic activity. Among all cancer treatment types (i.e., surgery, chemotherapy, radiotherapy), electroporation (EP) has emerged as a safe, less invasive, and effective approach for cancer treatment. Reversible EP, using an...
Source: Cancers - October 31, 2022 Category: Cancer & Oncology Authors: Silvia Pisani Giulia Bertino Adriele Prina-Mello Laura Deborah Locati Simone Mauramati Ida Genta Rossella Dorati Bice Conti Marco Benazzo Tags: Review Source Type: research
High expression of PYK2 is associated with poor prognosis and cancer progression in early-stage cervical carcinoma
Medicine (Baltimore). 2022 Oct 14;101(41):e31178. doi: 10.1097/MD.0000000000031178.ABSTRACTProline-rich tyrosine kinase-2 (PYK2), also known as calcium dependent tyrosine kinase, regulates different signal transduction cascades that control cell proliferation, migration, and invasion. However, the role of PYK2 in cervical cancer remains to be elucidated. The current study retrospectively included 134 patients with cervical cancer from December 2007 to September 2014. PYK2 expression was detected in tissue microarray and cervical cancer cell lines. Statistical analysis was performed to evaluate its clinicopathological signi...
Source: Cancer Control - October 18, 2022 Category: Cancer & Oncology Authors: Can Zhang Xinghua Zhu Yong Li Jia Shao Haibo Xu Lei Chen Youli Dan Hua Jin Aiqin He Source Type: research
Cancers, Vol. 14, Pages 4794: AKT Regulation of ORAI1-Mediated Calcium Influx in Breast Cancer Cells
ry R. Monteith
Although breast cancer cells often exhibit both abnormal AKT signaling and calcium signaling, the association between these two pathways is unclear. Using a combination of pharmacological tools, siRNA and CRISPR/Cas9 gene silencing techniques, we investigated the association between PTEN, AKT phosphorylation and calcium signaling in a basal breast cancer cell line. We found that siRNA-mediated PTEN silencing promotes AKT phosphorylation and calcium influx in MDA-MB-231 cells. This increase in AKT phosphorylation and calcium influx was phenocopied by the pharmacological AKT activator, SC79. The increased ...
Source: Cancers - September 30, 2022 Category: Cancer & Oncology Authors: Alice Hui Li Bong Trinh Hua Choon Leng So Amelia A. Peters M élanie Robitaille Yin Yi Tan Sarah J. Roberts-Thomson Gregory R. Monteith Tags: Article Source Type: research
Lipid-coated albumin-paclitaxel nanoparticles loaded with sorcin-siRNA reverse cancer chemoresistance via restoring intracellular calcium ion homeostasis
Chemoresistance is often a cause of the failure of chemotherapy in cancer treatment. Sorcin (SRI) is a soluble resistance-related calcium-binding protein involved in chemoresistant processes and is overexpress...
Source: Journal of Nanobiotechnology - July 7, 2022 Category: Nanotechnology Authors: Chenglong Wang, Xiaolin Xu, Peipei Zhang, Shuhan Xiong, Jia Yuan, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Hongjing Dou and Guoxiong Xu Tags: Research Source Type: research
Functions and Clinical Significance of CACNA2D1 in Gastric Cancer
CONCLUSIONS: The present study indicates that CACNA2D1 regulates the apoptosis signaling pathway and may have potential as a biomarker for cancer growth and as a therapeutic target for GC.PMID:35445337 | DOI:10.1245/s10434-022-11752-5
Source: Ann Oncol - April 21, 2022 Category: Cancer & Oncology Authors: Hiroyuki Inoue Atsushi Shiozaki Toshiyuki Kosuga Hiroki Shimizu Michihiro Kudou Takuma Ohashi Tomohiro Arita Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Eiichi Konishi Eigo Otsuji Source Type: research
Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress
Biochem Biophys Res Commun. 2022 Mar 31;608:156-162. doi: 10.1016/j.bbrc.2022.03.156. Online ahead of print.ABSTRACTCalpains are cysteine proteases activated in response to intracellular calcium signaling. Activated calpains regulate various cellular functions by degrading substrate molecules in a site-specific manner. Although most calpains are localized in the cytosol, we previously reported that calpain-5 exists in the mitochondria. The mitochondrial calpain-5 is activated during endoplasmic reticulum (ER) stress. However, the substrate of calpain-5, as well as the physiological significance of calpain-5 activation, has...
Source: Biochemical and Biophysical Research communications - April 10, 2022 Category: Biochemistry Authors: Yusaku Chukai Ginga Ito Masahide Konno Yuri Sakata Taku Ozaki Source Type: research
Ginsenoside Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via mitochondrial ROS and ER stress-mediated signaling pathway
Arch Pharm Res. 2022 Mar 24. doi: 10.1007/s12272-022-01377-3. Online ahead of print.ABSTRACTGinsenoside-Rh1 (Rh1) is a ginseng-derived compound that has been reported to exert anticancer effects by regulating cell cycle arrest and apoptosis according to reactive oxygen species (ROS) production. However, the effects of Rh1 on mitochondrial dysfunction are involved in triple negative breast cancer (TNBC) cell apoptosis, and the related molecular mechanisms remain unknown. Rh1 treatment induced cell toxicity less than 50% at 50 μM. In addition, Rh1 induced apoptosis in TNBC cells through cleaved caspase-3 activation and G1/S...
Source: Cell Research - March 24, 2022 Category: Cytology Authors: Yujin Jin Diem Thi Ngoc Huynh Kyung-Sun Heo Source Type: research
