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Infectious Disease: Hepatitis
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Total 297 results found since Jan 2013.
Anti-inflammatory and anti-fibrotic effects of modafinil in nonalcoholic liver disease
Biomed Pharmacother. 2021 Dec;144:112372. doi: 10.1016/j.biopha.2021.112372. Epub 2021 Oct 28.ABSTRACTSmall- and intermediate-conductance Ca2+-activated K+ channels, KCa2.3 and KCa3.1, are involved in cellular signaling processes associated with inflammation and fibrosis. KCa2.3 and KCa3.1 are upregulated by proinflammatory cytokines and profibrotic growth factors. Cyclic AMP, which downregulates KCa2.3 and KCa3.1, is elevated by modafinil in cells; accordingly, we investigated whether modafinil exerts anti-inflammatory and anti-fibrotic responses via KCa2.3- and KCa3.1-mediated pathways in high-fat diet (HFD)- or thioacet...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 19, 2021 Category: Drugs & Pharmacology Authors: Shinkyu Choi Ji Aee Kim Haiyan Li Seong-Eun Jo Huisu Lee Tae Hun Kim Minje Kim Seong-Jin Kim Suk Hyo Suh Source Type: research
Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3
Toxicol Appl Pharmacol. 2021 Nov 12:115795. doi: 10.1016/j.taap.2021.115795. Online ahead of print.ABSTRACTA chronic liver disease named autoimmune hepatitis (AIH) will carry elevated levels of inflammatory cytokines, but there is currently no effective treatment to cure it. Histone deacetylase 3 (HDAC3) takes an important position in regulating the expression of inflammatory genes. Nimbolide (NIB) is a limonoid extracted from the neem tree (Azadirachta indica) that has been found to be effective against many diseases, including cancer, scleroderma, and acute respiratory distress syndrome. Here, we investigated the protect...
Source: Toxicology and Applied Pharmacology - November 15, 2021 Category: Toxicology Authors: Dingchao Xia Dazhi Chen Tingchen Cai Lujian Zhu Yanhan Lin Sijie Yu Kailu Zhu Xiaodong Wang Lanman Xu Yongping Chen Source Type: research
Blocking neddylation elicits antiviral effect against hepatitis B virus replication
CONCLUSION: The manipulation of the neddylation pathway can thus provide new tools interfering with HBV persistence as well as novel therapeutic strategies against chronic hepatitis B.PMID:34716866 | DOI:10.1007/s11033-021-06886-w
Source: Mol Biol Cell - October 30, 2021 Category: Molecular Biology Authors: Karima Abounouh Mohammad Enamul Hoque Kayesh Haya Altawalah Bouchra Kitab Shuko Murakami Shintaro Ogawa Yasuhito Tanaka Hind Dehbi Pascal Pineau Michinori Kohara Soumaya Benjelloun Kyoko Tsukiyama-Kohara Sayeh Ezzikouri Source Type: research
Overexpressed GNAZ predicts poor outcome and promotes G0/G1 cell cycle progression in hepatocellular carcinoma
CONCLUSION: Our study demonstrated that GNAZ plays a pivotal role as a potential oncogene and predicts poor prognosis in patients with HCC. It promotes tumor proliferation via cell cycle arrest, apoptosis, migration, and invasion. Thus, GNAZ may be a potential candidate biomarker providing useful insight into hepatocarcinogenesis and aggressiveness.PMID:34530087 | DOI:10.1016/j.gene.2021.145964
Source: Gene - September 16, 2021 Category: Genetics & Stem Cells Authors: Feng Tian Daxia Cai Source Type: research
Down-Regulation of HBXIP Inhibits Non-Small Cell Lung Cancer Growth and Enhances the Anti-Tumor Immunity of Mice by Reducing NRP-1
CONCLUSION: Down-regulation of HBXIP reduced Lin28B-mediated NRP-1 to suppress NSCLC cell growth and enhance anti-tumor immunity.PMID:34452886
Source: Clinical Lung Cancer - August 28, 2021 Category: Cancer & Oncology Authors: Lulu Wang Mao Sun Xing Lin Yongyang Lei Zhe Yin Wei Zhou Source Type: research
