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Infectious Disease: Hepatitis
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Total 297 results found since Jan 2013.
Calcitriol attenuates liver fibrosis through hepatitis C virus nonstructural protein 3-transactivated protein 1-mediated TGF β1/Smad3 and NF-κB signaling pathways
CONCLUSION: Our results suggest that calcitriol may be employed as an adjuvant therapy for hepatic fibrosis and that NS3TP1 is a unique, prospective therapeutic target in hepatic fibrosis.PMID:37274069 | PMC:PMC10237113 | DOI:10.3748/wjg.v29.i18.2798
Source: World Journal of Gastroenterology - June 5, 2023 Category: Gastroenterology Authors: Liu Shi Li Zhou Ming Han Yu Zhang Yang Zhang Xiao-Xue Yuan Hong-Ping Lu Yun Wang Xue-Liang Yang Chen Liu Jun Wang Pu Liang Shun-Ai Liu Xiao-Jing Liu Jun Cheng Shu-Mei Lin Source Type: research
Transfection efficacy and drug release depends upon the PEG derivative in cationic lipoplexes: Evaluation in 3D in vitro model and in vivo
AbstractThe goal of the study was to estimate transfection efficacy and drug release in function of the PEG derivative in cationic liposomes and lipoplexes in both 2D and 3D in vitro models as well as in a mouse model (in vivo). For this purpose, cationic PEGylated nanocarriers based on OrnOrnGlu(C16H33)2 lipopeptides were fabricated and characterized. The nanocarriers were loaded with DNA plasmid pGL3 or with siRNA targeting 5 ′-UTR region of Hepatitis C virus, and their transfection efficacies were studied by luciferase test or by PCR technique, respectively. The pGL3-lipoplexes containing PEG derivativeb (6 mol % P...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 4, 2023 Category: Materials Science Authors: Gileva A. M.,
Koloskova O. O.,
Nosova A. S.,
Vishniakova L. I.,
Simonova V. A.,
Kurbanova L. A.,
Egorenkov E. A.,
Smirnov V. V.,
Budanova U. A.,
Sebyakin Yu L.,
Suzina N. E.,
Khaitov M. R.,
Markvicheva E. Tags: RESEARCH ARTICLE Source Type: research
Suppression of SIRT1/FXR signaling pathway contributes to oleanolic acid-induced liver injury
In conclusion, our study reveals that SIRT1/FXR pathway is crucial in OA-induced hepatotoxicity. Activation of SIRT1/HNF1α/FXR axis may represent a novel therapeutic target for ameliorating OA and other herb-induced hepatotoxicity.PMID:37028458 | DOI:10.1016/j.taap.2023.116509
Source: Toxicology and Applied Pharmacology - April 7, 2023 Category: Toxicology Authors: Songjie Liao Xiaolong Fu Jianxiang Huang Yi Wang Yuanfu Lu Shaoyu Zhou Source Type: research
Pharmacokinetics of Jnj-73763989 And Jnj-56136379 (Bersacapavir) In Participants With Moderate Hepatic Impairment
This article is protected by copyright. All rights reserved.PMID:36786053 | DOI:10.1002/jcph.2214
Source: The Journal of Clinical Pharmacology - February 14, 2023 Category: Drugs & Pharmacology Authors: Thomas N Kakuda Atef Halabi Gernot Klein Madhu Sanga Carine Guinard-Azadian Monika Kowalik Katja Nedoschinsky Julius Nangosyah Emmanuel Njumbe Ediage Vera Hillewaert Peter Verboven Ivo Goris Jan Snoeys Martyn Palmer Michael Biermer Source Type: research
