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Infectious Disease: Hepatitis

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Total 297 results found since Jan 2013.

Down-Regulation of HBXIP Inhibits Non-Small Cell Lung Cancer Growth and Enhances the Anti-Tumor Immunity of Mice by Reducing NRP-1
CONCLUSION: Down-regulation of HBXIP reduced Lin28B-mediated NRP-1 to suppress NSCLC cell growth and enhance anti-tumor immunity.PMID:34452886
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Lulu Wang Mao Sun Xing Lin Yongyang Lei Zhe Yin Wei Zhou Source Type: research

NLRP3 Inflammasome Activation is a Prognostic Marker of Recovery in HEV-Infected Patients
This study highlighted the significance of upregulated NLRP3 inflammasome leading to increased production of IL-18 and IL-1β cytokines in sera of AVH patients. Thus, it indicated the role of Th1 response acting through the NLRP3 pathway which might have been helpful in the recovery of AVH patients. These promising results open multiple treatment avenues where specific inhibitors can be designed to modulate the progress of disease and its pathogenicity.PMID:34982235 | DOI:10.1007/s00284-021-02736-x
Source: Current Microbiology - January 4, 2022 Category: Microbiology Authors: Vikram Thakur Radha Kanta Ratho Mini P Singh Yogesh Chawla Sunil Taneja Source Type: research

Transfection efficacy and drug release depends upon the PEG derivative in cationic lipoplexes: Evaluation in 3D in vitro model and in vivo
J Biomed Mater Res B Appl Biomater. 2023 May 3. doi: 10.1002/jbm.b.35259. Online ahead of print.ABSTRACTThe goal of the study was to estimate transfection efficacy and drug release in function of the PEG derivative in cationic liposomes and lipoplexes in both 2D and 3D in vitro models as well as in a mouse model (in vivo). For this purpose, cationic PEGylated nanocarriers based on OrnOrnGlu(C16 H33 )2 lipopeptides were fabricated and characterized. The nanocarriers were loaded with DNA plasmid pGL3 or with siRNA targeting 5'-UTR region of Hepatitis C virus, and their transfection efficacies were studied by luciferase test ...
Source: Biomed Res - May 3, 2023 Category: Research Authors: Gileva A M Koloskova O O Nosova A S Vishniakova L I Simonova V A Kurbanova L A Egorenkov E A Smirnov V V Budanova U A Sebyakin Yu L Suzina N E Khaitov M R Markvicheva E Source Type: research

The modulation of hepatitis C virus 1a replication by PKR is dependent on NF-kB mediated interferon beta response in Huh7.5.1 cells.
Abstract Protein kinase R (PKR), a sensor of double-stranded RNA, plays an important role in the host response to viral infection. Hepatitis C genotype 2a virus (HCV2a) has been shown to induce PKR activation to suppress the translation of antiviral interferon stimulated genes (ISGs), suggesting that PKR inhibitor can be beneficial for treating chronically HCV-infected patients in conjunction with interferon alpha and ribavirin. However, in this study, we found that PKR inhibition using siRNA PKR, shRNA PKR or PKR inhibitor enhanced HCV 1a replication and rendered Huh7.5.1 cells more susceptible to HCV1a infection...
Source: Virology - February 8, 2013 Category: Virology Authors: Zhang L, Alter HJ, Wang H, Jia S, Wang E, Marincola FM, Shih JW, Wang RY Tags: Virology Source Type: research

Interferon alpha and ribavirin collaboratively regulate p38 mitogen-activated protein kinase signaling in hepatoma cells.
Abstract Signaling events triggered by interferon alpha (IFN-α) and ribavirin are involved in anti-hepatitis C virus (HCV) action. The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in HCV pathogenesis. Effects of IFN-α and ribavirin on p38 MAPK signaling were investigated in human hepatoma cells. Type I IFN receptor 2 (IFNAR2) mediated IFN-α-induced p38 MAPK phosphorylation. Also, p38 MAPK phosphorylation was enhanced by ribavirin. Treatment for 48h with a combination of IFN-α and ribavirin increased p38 MAPK phosphorylation, whereas the treatment for 72h reduced p38 MAPK phosphor...
Source: Cytokine - February 11, 2013 Category: Molecular Biology Authors: He SF, Wang W, Ren H, Zhao LJ, Qi ZT Tags: Cytokine Source Type: research

BST2/Tetherin inhibits hepatitis C virus production in human hepatoma cells.
Abstract Hepatitis C virus (HCV) infection is a common cause of chronic hepatitis and is currently treated with alpha interferon (IFN-α)-based therapies. IFN-induced cell membrane protein BST2 (also known as CD317, HM1.24 or tetherin) has been reported to tether a broad range of lipid-enveloped viruses on cell surfaces. However, whether HCV is sensitive to BST2 remains controversial. Here we established a Huh7.5-BST2-TO cell line, in which BST2 expression is regulated by tetracycline. Our results showed that the effect of BST2 on inhibiting HCV production was dependent on its expression level. Highly expressed BS...
Source: Antiviral Research - February 16, 2013 Category: Virology Authors: Pan XB, Qu XW, Jiang D, Zhao XL, Han JC, Wei L Tags: Antiviral Res Source Type: research