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Source: British Journal of Pharmacology
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Total 109 results found since Jan 2013.
Protein Phosphatase 2A (PP2A) Regulation of Markers of Extracellular Matrix Remodelling in HCC Cells: Functional Consequences for Tumour Invasion
Conclusion and ImplicationsOA increases MMP‐9 through a decrease in PP2A activity and PP2Ac and is mediated by AP‐1 binding sties on the MMP‐9 promoter. As the functional consequences of this and overexpression of CIP2A, cell migration was increased. Hence, PP2A inhibition induces a metastatic phenotype through alterations in MMP‐9 in Hep3B cells.
Source: British Journal of Pharmacology - February 26, 2017 Category: Drugs & Pharmacology Authors: M P Ward, J P Spiers Tags: RESEARCH PAPER Source Type: research
Metformin attenuates angiotensin II ‐induced TGFβ1 expression by targeting hepatocyte nuclear factor 4α
Conclusions and ImplicationsHNF4α mediated AngII‐induced TGFβ1 transcription and cardiac fibrosis. Metformin inhibited AngII‐induced HNF4α expression via AMPK activation, thus decreasing TGFβ1 transcription and cardiac fibrosis. These findings reveal a novel antifibrotic mechanism of action of metformin and identify HNF4α as a new potential therapeutic target for cardiac fibrosis.
Source: British Journal of Pharmacology - February 23, 2017 Category: Drugs & Pharmacology Authors: Ruifei Chen, Yenan Feng, Jimin Wu, Yao Song, Hao Li, Qiang Shen, Dan Li, Jianshu Zhang, Zhizhen Lu, Han Xiao, Youyi Zhang Tags: RESEARCH PAPER THEMED ISSUE Source Type: research
Potent effects of dioscin against pancreatic cancer via miR ‐149‐3P‐mediated inhibition of the Akt1 signalling pathway
Conclusions and ImplicationsCollectively, these findings confirmed the potent effects of dioscin against pancreatic cancer and also provided novel insights into the mechanisms of the compound as a potential candidate for the treatment of pancreatic cancer.
Source: British Journal of Pharmacology - February 13, 2017 Category: Drugs & Pharmacology Authors: Lingling Si, Lina Xu, Lianhong Yin, Yan Qi, Xu Han, Youwei Xu, Yanyan Zhao, Kexin Liu, Jinyong Peng Tags: RESEARCH PAPER Source Type: research
Potent effects of dioscin against pancreatic cancer via miR ‐149‐3P‐mediated inhibition of AKT1 signaling pathway
CONCLUSIONS AND IMPLICATIONSCollectively, these findings confirmed the potent effects of dioscin against pancreatic cancer and also provided novel insights into the mechanisms of the compound as one potential candidate for the treatment of pancreatic cancer in the future.
Source: British Journal of Pharmacology - January 16, 2017 Category: Drugs & Pharmacology Authors: Lingling Si, Lina Xu, Lianhong Yin, Yan Qi, Xu Han, Youwei Xu, Yanyan Zhao, Kexin Liu, Jinyong Peng Tags: RESEARCH PAPER Source Type: research
Ribosomal Protein S3 Gene Silencing Protects Against Experimental Allergic Asthma
Conclusions and ImplicationsWe reported here that RPS3 gene silencing ameliorated experimental asthma probably via interruption of the NF‐κB activity, postulating that RPS3 is a novel therapeutic target for allergic airway inflammation.
Source: British Journal of Pharmacology - December 31, 2016 Category: Drugs & Pharmacology Authors: Jinrui Dong, Wupeng Liao, Hong Yong Peh, Tze Khee Chan, W. S. Daniel Tan, Li Li, Amy Yong, W. S. Fred Wong Tags: RESEARCH PAPER Source Type: research
Adenosine A2A Receptor Promotes Collagen Type III Synthesis Via β‐Catenin Activation in Human Dermal Fibroblasts
Conclusions and ImplicationsA2AR stimulation promotes Col3 synthesis via canonical and non‐canonical β‐catenin activation, consistent with the role of A2AR in dermal fibrosis and scarring.
Source: British Journal of Pharmacology - August 31, 2016 Category: Drugs & Pharmacology Authors: Gibran Shaikh, Jin Zhang, Miguel Perez ‐Aso, Aranzazu Mediero Munoz, Bruce Cronstein Tags: RESEARCH PAPER Source Type: research
Inhibition of PI3K promotes dilation of human small airways in a rho kinase ‐dependent manner
Conclusion and ImplicationsPI3Kδ inhibitors act as dilators of human small airways. Taken together, these findings provide alternative approaches to the clinical management of airway obstruction in asthma.
Source: British Journal of Pharmacology - August 2, 2016 Category: Drugs & Pharmacology Authors: Cynthia J Koziol ‐White, Edwin J Yoo, Gaoyuan Cao, Jie Zhang, Eleni Papanikolaou, Ivan Pushkarsky, Adam Andrews, Blanca E Himes, Robert D Damoiseaux, Stephen B Liggett, Dino Di Carlo, Richard C Kurten, Reynold A Panettieri Tags: RESEARCH PAPER Source Type: research
Protection from interferon ‐β‐induced neuronal apoptosis through stimulation of muscarinic acetylcholine receptors coupled to ERK1/2 activation
Conclusions and implicationsStimulation of mAChRs counteracted IFN‐β‐induced neuronal apoptosis through the activation of ERK1/2 signalling. The data indicate that activation of ERK1/2‐coupled mAChRs may be an effective strategy for preventing IFNs neurotoxicity. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - July 30, 2016 Category: Drugs & Pharmacology Authors: Maria C. Olianas, Simona Dedoni, Pierluigi Onali Tags: RESEARCH PAPER Source Type: research
Inhibition of Phosphoinositide 3 ‐Kinase (PI3K) promotes dilation of human small airways in a Rho kinase‐dependent manner
Asthma manifests as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyperresponsiveness (AHR). Although the molecular mechanisms remain unclear, activation of specific phosphoinositide 3‐kinase (PI3K) isoforms mediate inflammation and AHR (Lee et al., 2006; Nashed et al., 2007; Ali et al., 2008; Takeda et al., 2009). We aimed to determine whether inhibition of PI3Kδ evokes dilation of airways, and to elucidate potential mechanisms. Human precision cut lung slices (hPCLS) from non‐asthma donors, and primary human airway smooth muscle cells (HASM) from both non‐asthma and asthma donors, ...
Source: British Journal of Pharmacology - June 27, 2016 Category: Drugs & Pharmacology Authors: Cynthia J. Koziol ‐White, Edwin J. Yoo, Gaoyuan Cao, Jie Zhang, Eleni Papanikolaou, Ivan Pushkarsky, Adam Andrews, Blanca E. Himes, Robert D. Damoiseaux, Stephen B. Liggett, Dino Di Carlo, Richard C. Kurten, Reynold A. Panettieri Tags: RESEARCH PAPER Source Type: research
Inhibition of Phosphoinositide 3‐Kinase (PI3K) promotes dilation of human small airways in a Rho kinase‐dependent manner
Asthma manifests as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyperresponsiveness (AHR). Although the molecular mechanisms remain unclear, activation of specific phosphoinositide 3‐kinase (PI3K) isoforms mediate inflammation and AHR (Lee et al., 2006; Nashed et al., 2007; Ali et al., 2008; Takeda et al., 2009). We aimed to determine whether inhibition of PI3Kδ evokes dilation of airways, and to elucidate potential mechanisms. Human precision cut lung slices (hPCLS) from non‐asthma donors, and primary human airway smooth muscle cells (HASM) from both non‐asthma and asthma donors, ...
Source: British Journal of Pharmacology - June 27, 2016 Category: Drugs & Pharmacology Authors: Cynthia J. Koziol‐White, Edwin J. Yoo, Gaoyuan Cao, Jie Zhang, Eleni Papanikolaou, Ivan Pushkarsky, Adam Andrews, Blanca E. Himes, Robert D. Damoiseaux, Stephen B. Liggett, Dino Di Carlo, Richard C. Kurten, Reynold A. Panettieri Tags: RESEARCH PAPER Source Type: research
Apelin‐13 administration protects against ischaemia/reperfusion‐mediated apoptosis through the FoxO1 pathway in high‐fat diet‐induced obesity
Conclusions and ImplicationsThese data reveal apelin as a novel regulator of FoxO1 in cardiac cells and provide evidence for the potential of apelin‐13 in prevention of apoptosis and mitochondrial damage in conditions combining I/R injury and obesity.
Source: British Journal of Pharmacology - April 19, 2016 Category: Drugs & Pharmacology Authors: Frederic Boal, Andrei Timotin, Jessica Roumegoux, Chiara Alfarano, Denis Calise, Rodica Anesia, Angelo Parini, Philippe Valet, Helene Tronchere, Oksana Kunduzova Tags: RESEARCH PAPER Source Type: research
Inhibition of Fatty Acid Synthase is Protective in Pulmonary Hypertension
ConclusionsOur results demonstrate that FAS activity gets modulated in PH and its inhibition may serve as a new therapeutic approach to treat PH.
Source: British Journal of Pharmacology - April 6, 2016 Category: Drugs & Pharmacology Authors: Neetu Singh, Amit Manhas, Gurpreet Kaur, Kumaravelu Jagavelu, Kashif Hanif Tags: RESEARCH PAPER Source Type: research
Drp‐1, a potential therapeutic target for brain ischaemic stroke
Conclusions and ImplicationsOur findings that Drp‐1 increases the resistance of neurons of hippocampal CA3 affected by global ischaemia and contributes to the tolerance conferred by IPC highlight Drp‐1 as a potential therapeutic target for brain ischaemic stroke.
Source: British Journal of Pharmacology - April 6, 2016 Category: Drugs & Pharmacology Authors: W Zuo, P F Yang, J Chen, Z Zhang, N H Chen Tags: RESEARCH PAPER Source Type: research
Apelin‐13 administration protects against ischemia/reperfusion‐mediated apoptosis through FoxO1 pathway in high‐fat diet‐induced obesity.
Conclusions and ImplicationsThese data uncover apelin as a novel regulator of FoxO1 in cardiac cells and provide the evidence for the potential of apelin‐13 in prevention of apoptosis and mitochondrial damage in conditions combining I/R injury and obesity.
Source: British Journal of Pharmacology - March 23, 2016 Category: Drugs & Pharmacology Authors: Frederic Boal, Andrei Timotin, Jessica Roumegoux, Chiara Alfarano, Denis Calise, Rodica Anesia, Angelo Parini, Philippe Valet, Helene Tronchere, Oksana Kunduzova Tags: Research Paper Source Type: research
Drp‐1, a potential therapeutic target for brain ischemic stroke
Conclusions and ImplicationsOur findings that Drp‐1 may increase the resistance of neurons of hippocampal CA3 affected by global ischemia and the tolerance conferred by IPC highlight Drp‐1 as a potential target for translocation to effective therapy for brain ischemic stroke.
Source: British Journal of Pharmacology - February 24, 2016 Category: Drugs & Pharmacology Authors: W Zuo, P F Yang, J Chen, Z Zhang, N H Chen Tags: RESEARCH PAPER Source Type: research
