Filtered By:
Source: British Journal of Pharmacology
This page shows you your search results in order of date. This is page number 4.
Order by Relevance | Date
Total 109 results found since Jan 2013.
Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV4 channels
Conclusions and ImplicationsEugenol activates TRPV4 channels in mesenteric artery endothelial cells, leading to vasorelaxation, and reduces systemic BP in vivo. Eugenol may be therapeutically useful as an antihypertensive agent and is a viable molecular candidate from which to develop second‐generation TRPV4 channel activators that reduce BP.
Source: British Journal of Pharmacology - May 19, 2015 Category: Drugs & Pharmacology Authors: Dieniffer Peixoto‐Neves, Qian Wang, Jose H Leal‐Cardoso, Luciana V Rossoni, Jonathan H Jaggar Tags: RESEARCH PAPER Source Type: research
A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway
Conclusions and ImplicationsIDHP attenuated the cardiac fibrosis induced by isoprenaline through a NOX2/ROS/p38 pathway. These novel findings suggest that IDHP is a potential pharmacological candidate for the treatment of cardiac fibrosis, induced by β‐adrenoceptor agonists.
Source: British Journal of Pharmacology - May 5, 2015 Category: Drugs & Pharmacology Authors: Qian Yin, Haiyan Lu, Yajun Bai, Aiju Tian, Qiuxiang Yang, Jimin Wu, Chengzhi Yang, Tai‐Ping Fan, Youyi Zhang, Xiaohui Zheng, Xiaopu Zheng, Zijian Li Tags: RESEARCH PAPER Source Type: research
The orphan receptor NOR1 participates in isoprenaline‐induced cardiac hypertrophy by regulating PARP‐1
Conclusions and ImplicationsThis is the first evidence that NOR1 was involved in isoprenaline‐induced cardiac hypertrophy. The pro‐hypertrophic effect of NOR1 can be partly attributed to its regulation of PARP‐1 enzymic activity.
Source: British Journal of Pharmacology - March 26, 2015 Category: Drugs & Pharmacology Authors: Xiao‐Jun Feng, Hui Gao, Si Gao, Zhuoming Li, Hong Li, Jing Lu, Jiao‐Jiao Wang, Xiao‐Yang Huang, Min Liu, Jian Zou, Jian‐Tao Ye, Pei‐Qing Liu Tags: RESEARCH PAPER Source Type: research
IDHP Attenuates β‐Adrenergic Receptor Mediated Cardiac Fibrosis depending on NOX2/ROS/p38 Pathway
CONCLUSIONS AND IMPLICATIONSIDHP attenuates cardiac fibrosis induced by isoproterenol through NOX2/ROS/p38 pathway. These novel findings suggest that IDHP is a potential pharmacological candidate for the treatment of cardiac fibrosis.
Source: British Journal of Pharmacology - March 13, 2015 Category: Drugs & Pharmacology Authors: Qian Yin, Haiyan Lu, Yajun Bai, Aiju Tian, Qiuxiang Yang, Jimin Wu, Chengzhi Yang, Tai‐Ping Fan, Youyi Zhang, Xiaohui Zheng, Xiaopu Zheng, Zijian Li Tags: Research Paper – Chinese innovation in cardiovascular drug discovery Themed issue Source Type: research
Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all‐trans‐retinol in human retinal pigmented epithelial cells
Conclusion and implicationsOur data provides the first evidence of OATP1A2 expression in human RPE and more importantly, its novel role in the cellular uptake of atROL, which might be essential to the proper functioning of the canonical visual cycle. Our findings contribute to understanding the molecular mechanisms involved in retinoid transport between the RPE and photoreceptors and provide novel insights into potential pharmaceutical interventions for visual cycle disruption associated with retinal degenerations.
Source: British Journal of Pharmacology - January 5, 2015 Category: Drugs & Pharmacology Authors: Ting Chan, Ling Zhu, Michele C. Madigan, Ke Wang, Weiyong Shen, Mark C. Gillies, Fanfan Zhou Tags: Research Paper Source Type: research
Sonic hedgehog increases the skin wound‐healing ability of mouse embryonic stem cells through the microRNA 200 family
Conclusions and ImplicationsMouse ESCs accelerated skin wound healing by shh through down‐regulating E‐cadherin, an effect dependent on mmu‐miR‐141 and ‐200b. Our data provides evidence for the effectiveness of shh in stem cell‐based therapy in vivo.
Source: British Journal of Pharmacology - December 23, 2014 Category: Drugs & Pharmacology Authors: Han Na Suh, Ho Jae Han Tags: RESEARCH PAPER Source Type: research
The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells
Conclusions and ImplicationsSimilar to TOP2A poisons, DRZ induces DNA double‐strand breaks followed by activation of DNA damage response. The DNA damage‐triggered ATF3 controls the level of p53 accumulation as well as double‐strand breaks generation and is proposed to serve as a switch between DNA damage and cell death following DRZ treatment. These findings suggest a mechanistic explanation for the diverse clinical observations associated with DRZ.
Source: British Journal of Pharmacology - December 17, 2014 Category: Drugs & Pharmacology Authors: Shiwei Deng, Tiandong Yan, Teodora Nikolova, Dominik Fuhrmann, Andrea Nemecek, Ute Gödtel‐Armbrust, Bernd Kaina, Leszek Wojnowski Tags: Research Paper Source Type: research
Diadenosine tetraphosphate induces tight junction disassembly thus increasing corneal epithelial permeability
Conclusions and ImplicationsAp4A increased corneal epithelial barrier permeability. Its application could improve ocular drug delivery and consequently therapeutic efficiency.
Source: British Journal of Pharmacology - December 15, 2014 Category: Drugs & Pharmacology Authors: P Loma, A Guzman‐Aranguez, M J Pérez de Lara, J Pintor Tags: RESEARCH PAPER Source Type: research
A novel mechanism for cytoprotection against hypoxic injury: δ‐opioid receptor‐mediated increase in Nrf2 translocation
ConclusionsDOR is cytoprotective against H/R injury and this effect is at least partially dependent on Nrf2 function.
Source: British Journal of Pharmacology - December 2, 2014 Category: Drugs & Pharmacology Authors: Shan Cao, Dongman Chao, Honghao Zhou, Gianfranco Balboni, Ying Xia Tags: Research Paper Source Type: research
Autocrine secretion of 15d‐PGJ2 mediates simvastatin‐induced apoptotic burst in human metastatic melanoma cells
Conclusions and ImplicationsWe characterized simvastatin‐induced activation of the 15d‐PGJ2/FABP5 signalling cascades, which triggered an apoptotic burst in melanoma cells but did not affect primary human melanocytes. These data support the rationale for the pharmacological targeting of 15d‐PGJ2 in metastatic melanoma.
Source: British Journal of Pharmacology - December 1, 2014 Category: Drugs & Pharmacology Authors: Christine Wasinger, Martin Künzl, Christoph Minichsdorfer, Christoph Höller, Maria Zellner, Martin Hohenegger Tags: RESEARCH PAPER Source Type: research
Oxidized LDL‐induced angiogenesis involves sphingosine 1‐phosphate: prevention by anti‐S1P antibody
Conclusion and ImplicationsThese data highlight the role of S1P in angiogenesis induced by oxLDL both in HMEC‐1 cultured on Matrigel and in vivo in the Matrigel plug model in mice, and demonstrate that the anti‐S1P antibody effectively blocks the angiogenic effect of oxLDL.
Source: British Journal of Pharmacology - November 24, 2014 Category: Drugs & Pharmacology Authors: Caroline Camaré, Magali Trayssac, Barbara Garmy‐Susini, Elodie Mucher, Roger Sabbadini, Robert Salvayre, Anne Negre‐Salvayre Tags: RESEARCH PAPER Source Type: research
Genistein alleviates pressure overload‐induced cardiac dysfunction and interstitial fibrosis in mice
CONCLUSIONS AND IMPLICATIONSGen improved cardiac function and inhibited cardiac fibrosis in response to pressure overload. The underlying mechanism may involve regulation of the MTA3/TAK1/MKK4/JNK signaling pathway. Gen may serve as a novel agent for prevention and therapy of cardiac disorders associated with fibrosis.
Source: British Journal of Pharmacology - November 3, 2014 Category: Drugs & Pharmacology Authors: Wei Qin, Ning Du, Longyin Zhang, Xianxian Wu, Yingying Hu, Xiaoguang Li, Nannan Shen, Yang Li, Baofeng Yang, Chaoqian Xu, Zhiwei Fang, Yanjie Lu, Yong Zhang, Zhimin Du Tags: Research Paper – Chinese innovation in cardiovascular drug Discovery Themed Issue Source Type: research
Protective Effect of 23‐Hydroxybetulinic Acid on Doxorubicin‐induced Cardiotoxicity: A Correlation with the Inhibition of Carbonyl Reductase‐mediated Metabolism
Conclusions and ImplicationsInhibition of CBR‐mediated DOX metabolism might be one of the protective mechanisms of 23‐HBA against DOX‐induced cardiotoxicity. The present study provides a new research strategy guided by pharmacokinetic theory to elucidate the mechanism of drugs with unknown target.
Source: British Journal of Pharmacology - November 3, 2014 Category: Drugs & Pharmacology Authors: Fang Zhou, Gang Hao, Jingwei Zhang, Yuanting Zheng, Xiaolan Wu, Kun Hao, Fang Niu, Dan Luo, Yuan Sun, Liang Wu, Wencai Ye, Guangji Wang Tags: Research Paper – Chinese innovation in cardiovascular drug discovery Themed Issue Source Type: research
Diadenosine tetraphosphate induces tight junction disassembly increasing corneal epithelial permeability
Conclusions and ImplicationsAp4A increased corneal epithelial barrier permeability. Its application can contribute to improve ocular drug delivery and consequently therapeutic efficiency.
Source: British Journal of Pharmacology - October 9, 2014 Category: Drugs & Pharmacology Authors: P Lom, A Guzman‐Aranguez, M J Pérez de Lara, J Pintor Tags: Research Paper Source Type: research
Sonic hedgehog increases the skin wound healing ability of mouse embryonic stem cells through micro RNA 200 family
Conclusions and implicationsMouse ESCs accelerate skin wound healing by shh through the mmu‐miR‐141, ‐200b‐dependent downregulation of E‐cadherin. The experimental data provides evidence for shh's efficiency in future in vivo stem cell‐based therapy.
Source: British Journal of Pharmacology - September 25, 2014 Category: Drugs & Pharmacology Authors: Han Na Suh, Ho Jae Han Tags: Research Paper Source Type: research
