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Source: British Journal of Pharmacology
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Total 109 results found since Jan 2013.
Berberine improves mesenteric artery insulin sensitivity through up‐regulating insulin receptor‐mediated signaling in diabetic rats
Conclusions and ImplicationsBerberine improves diabetic vascular insulin sensitivity and mesenteric vasodilation through upregulating insulin receptor‐mediated signaling in diabetic rats. These findings suggest potential benefits of berberine in the prevention and adjunctive treatment of diabetic vascular complications. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - February 23, 2016 Category: Drugs & Pharmacology Authors: Feng‐Hao Geng, Guo‐Hua Li, Xing Zhang, Peng Zhang, Ming‐Qing Dong, Zhi‐Jing Zhao, Yuan Zhang, Ling Dong, Feng Gao Tags: RESEARCH PAPER THEMED ISSUE Source Type: research
Compound 9a, a novel synthetic histone deacetylase inhibitor, protects against septic injury in mice by suppressing MAPK signalling
Conclusions and ImplicationsOur findings suggest that Compound 9a protected against septic injury by suppressing MAPK‐mediated inflammatory signalling.
Source: British Journal of Pharmacology - February 22, 2016 Category: Drugs & Pharmacology Authors: So‐Jin Kim, Ki Seon Baek, Hyun‐Ju Park, Young Hoon Jung, Sun‐Mee Lee Tags: RESEARCH PAPER Source Type: research
Endothelin‐1 suppresses insulin‐stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells
Conclusions and ImplicationsActivation of ETA receptors with ET‐1 suppressed insulin‐induced Akt phosphorylation at Thr308 and Ser473 and [3H]2‐DG uptake in a GRK2‐dependent manner in skeletal muscle cells. These findings suggest that ETA receptors and GRK2 are potential targets for overcoming insulin resistance.
Source: British Journal of Pharmacology - February 15, 2016 Category: Drugs & Pharmacology Authors: Takahiro Horinouchi, Akimasa Hoshi, Takuya Harada, Tsunaki Higa, Sarita Karki, Koji Terada, Tsunehito Higashi, Yosuke Mai, Prabha Nepal, Yuichi Mazaki, Soichi Miwa Tags: RESEARCH PAPER Source Type: research
Threonine532 phosphorylation in ClC‐3 channels is required for angiotensin II‐induced Cl− current and migration in cultured vascular smooth muscle cells
Conclusions And ImplicationsClC‐3 protein phosphorylation at Thr532 by ROCK2 is required for AngII‐induced Cl− current and VSMC migration that are involved in AngII‐induced vascular remodelling in hypertension.
Source: British Journal of Pharmacology - January 15, 2016 Category: Drugs & Pharmacology Authors: Ming‐Ming Ma, Cai‐Xia Lin, Can‐Zhao Liu, Min Gao, Lu Sun, Yong‐Bo Tang, Jia‐Guo Zhou, Guan‐Lei Wang, Yong‐Yuan Guan Tags: RESEARCH PAPER Source Type: research
Single administration of recombinant IL‐6 restores the gene expression of lipogenic enzymes in liver of fasting IL‐6 deficient mice
Conclusions and ImplicationsIL‐6 sustains levels of hepatic lipogenic enzymes during fasting suggesting a direct involvement of STAT3. Our findings warn about clinical use of the STAT3‐associated signalling cytokines particularly against steatosis. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - January 11, 2016 Category: Drugs & Pharmacology Authors: A L Gavito, R Cabello, J Suarez, A Serrano, F J Pavón, M Vida, M Romero, V Pardo, D Bautista, S Arrabal, J Decara, A L Cuesta, A M Valverde, F Rodríguez de Fonseca, E Baixeras Tags: RESEARCH PAPER Source Type: research
9a, a novel synthetic histone deacetylase inhibitor, protects against septic injury by suppressing MAPK signaling in mice
Conclusions and ImplicationsOur findings suggest that 9a protects against septic injury by suppressing MAPK‐mediated inflammatory signaling. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - December 22, 2015 Category: Drugs & Pharmacology Authors: So‐Jin Kim, Ki Seon Baek, Hyun‐Ju Park, Young Hoon Jung, Sun‐Mee Lee Tags: RESEARCH PAPER Source Type: research
Endothelin‐1 suppresses insulin‐stimulated Akt phosphorylation and glucose uptake via G protein‐coupled receptor kinase 2 in skeletal muscle cells
Conclusions and ImplicationsActivation of ETAR with ET‐1 suppresses insulin‐induced Akt phosphorylation at Thr308 and Ser473 and [3H]2‐DG uptake in a GRK2‐dependent manner in skeletal muscle. These findings suggest that ETAR and GRK2 are potential targets for insulin resistance. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - December 11, 2015 Category: Drugs & Pharmacology Authors: Takahiro Horinouchi, Akimasa Hoshi, Takuya Harada, Tsunaki Higa, Sarita Karki, Koji Terada, Tsunehito Higashi, Yosuke Mai, Prabha Nepal, Yuichi Mazaki, Soichi Miwa Tags: RESEARCH PAPER Source Type: research
Threonine 532 phosphorylation in ClC‐3 is required for angiotensin II‐induced Cl‐ current and migration in cultured vascular smooth muscle cells
CONCLUSIONS AND IMPLICATIONSClC‐3 protein phosphorylation at threonine 532 by ROCK2 is required for AngII‐induced Cl‐ current and VSMC migration that are involved in AngII‐induced hypertensive vascular remodeling.
Source: British Journal of Pharmacology - November 12, 2015 Category: Drugs & Pharmacology Authors: Ming‐Ming Ma, Cai‐Xia Lin, Can‐Zhao Liu, Min Gao, Lu Sun, Yong‐Bo Tang, Jia‐Guo Zhou, Guan‐Lei Wang, Yong‐Yuan Guan Tags: RESEARCH PAPER Source Type: research
All‐trans retinoic acid protects against doxorubicin‐induced cardiotoxicity by activating the Erk2 signalling pathway
CONCLUSION AND IMPLICATIONATRA protected cardiomyocytes against doxorubicin‐induced toxicity by activating the Erk2 pathway without compromising the anticancer efficacy of doxorubicin. Therefore, ATRA may be a promising candidate as a cardioprotective agent against doxorubicin cardiotoxicity.
Source: British Journal of Pharmacology - October 27, 2015 Category: Drugs & Pharmacology Authors: Liang Yang, Cheng Luo, Cong Chen, Xun Wang, Wen Shi, Jiankang Liu Tags: RESEARCH PAPER Source Type: research
GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis
CONCLUSIONS AND IMPLICATIONSGPR55 is involved in the migratory behavior of colon carcinoma cells and may serve as a pharmacological target for the prevention of metastasis. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - October 5, 2015 Category: Drugs & Pharmacology Authors: J Kargl, L Andersen, C Hasenöhrl, D Feuersinger, A Stančić, A Fauland, C Magnes, A El‐Heliebi, S Lax, S Uranitsch, J Haybaeck, A Heinemann, R Schicho Tags: RESEARCH PAPER Source Type: research
Role for engagement of β‐arrestin2 by the transactivated EGFR in agonist‐specific regulation of δ receptor activation of ERK1/2
Conclusions and ImplicationsThe δ receptor‐mediated activation of ERK1/2 is via ligand‐specific transactivation of EGFR. This study adds new insights into the mechanism by which δ receptors activate ERK1/2.
Source: British Journal of Pharmacology - September 23, 2015 Category: Drugs & Pharmacology Authors: Le‐Sha Zhang, Yu‐Jun Wang, Yun‐Yue Ju, Gui‐Ying Zan, Chi Xu, Min‐Hua Hong, Yu‐Hua Wang, Zhi‐Qiang Chi, Jing‐Gen Liu Tags: RESEARCH PAPER Source Type: research
Valproic acid protects against haemorrhagic shock‐induced signalling changes via PPARγ activation in an in vitro model
CONCLUSION AND IMPLICATIONSChanges in GSK3β‐Ser9 phosphorylation in in vivo haemorrhagic shock models can be modelled in vitro, and this has identified a role for PPARγ activation in the protective role of VPA.
Source: British Journal of Pharmacology - September 1, 2015 Category: Drugs & Pharmacology Authors: Alexandra M E Zuckermann, Roberto M La Ragione, Deborah L Baines, Robin S B Williams Tags: RESEARCH PAPER Source Type: research
Role for engagement of β‐arrestin 2 by the transactivated EGFR in agonist‐specific regulation of δ receptor activation of ERK1/2
Conclusions and Implicationsδ Receptor‐mediated activation of ERK1/2 is via ligand‐specific transactivation of EGFR. This study gains a new insight into the mechanism by which δ receptor activates ERK1/2.
Source: British Journal of Pharmacology - July 25, 2015 Category: Drugs & Pharmacology Authors: Le‐Sha Zhang, Yu‐Jun Wang, Yun‐Yue Ju, Gui‐Ying Zan, Chi Xu, Min‐Hua Hong, Yu‐Hua Wang, Zhi‐Qiang Chi, Jing‐Gen Liu Tags: RESEARCH PAPER Source Type: research
Prevention of the degeneration of human dopaminergic neurons in an astrocyte co‐culture system allowing endogenous drug metabolism
Conclusions and ImplicationsOur new model system is a closer model of human brain tissue than conventional cultures. Its use for screening of candidate neuroprotectants may increase the predictiveness of a test battery.
Source: British Journal of Pharmacology - June 26, 2015 Category: Drugs & Pharmacology Authors: Liudmila Efremova, Stefan Schildknecht, Martina Adam, Regina Pape, Simon Gutbier, Benjamin Hanf, Alexander Bürkle, Marcel Leist Tags: RESEARCH PAPER Source Type: research
Induction of the inflammatory regulator A20 by gibberellic acid in airway epithelial cells
Conclusions and implicationsHere we show that A20 induction by GA3 attenuates inflammation in airway epithelial cells, at least in part through its effect on NF‐κB and IκBα. GA3 or gibberellin‐derived derivatives could potentially be developed into anti‐inflammatory drugs for the treatment of chronic inflammatory diseases associated with A20 dysfunction.
Source: British Journal of Pharmacology - May 25, 2015 Category: Drugs & Pharmacology Authors: J A Reihill, B Malcomson, A Bertelsen, S Cheung, A Czerwiec, R Barsden, J S Elborn, H Dürkop, B Hirsch, M Ennis, C Kelly, B C Schock Tags: Research Paper – Inflammation: Maladies, Models, Mechanisms & Molecules Themed Issue Source Type: research
