Induction of the inflammatory regulator A20 by gibberellic acid in airway epithelial cells

Conclusions and implicationsHere we show that A20 induction by GA3 attenuates inflammation in airway epithelial cells, at least in part through its effect on NF‐κB and IκBα. GA3 or gibberellin‐derived derivatives could potentially be developed into anti‐inflammatory drugs for the treatment of chronic inflammatory diseases associated with A20 dysfunction.

Source: British Journal of Pharmacology - May 25, 2015 Category: Drugs & Pharmacology Authors: J A Reihill, B Malcomson, A Bertelsen, S Cheung, A Czerwiec, R Barsden, J S Elborn, H Dürkop, B Hirsch, M Ennis, C Kelly, B C Schock Tags: Research Paper – Inflammation: Maladies, Models, Mechanisms & Molecules Themed Issue Source Type: research