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Source: British Journal of Pharmacology
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Total 109 results found since Jan 2013.
Inhibitory Cross‐talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress‐induced insulin resistance in skeletal muscle
Conclusions And ImplicationsInhibition of ERK signaling pathways by a chemical inhibitor and knockdown of ERK improved AMPK and Akt signalings and reversed ER stress‐induced insulin resistance in L6 myotubes. These findings suggest that ERK signaling plays an important role in the regulation of insulin signals in muscle cells under ER stress.
Source: British Journal of Pharmacology - February 4, 2013 Category: Drugs & Pharmacology Authors: Seung‐Lark Hwang, Yong‐Tae Jeong, Xian Li, Yong Deuk Kim, Lu Yue, Young‐Chae Chang, In‐Kyu Lee, Hyeun Wook Chang Tags: Research Paper Source Type: research
Il‐4 and Il‐13 Inhibit Il‐1β and Tnf‐α Induced Kinin B1 and B2 Receptors Through a Stat6 Dependent Mechanism
Conclusions And ImplicationsThese data show, for the first time, that IL‐4 and IL‐13 decrease kinin receptors in a STAT6‐dependent mechanism, which can be one important mechanism by which these cytokines exert their anti‐inflammatory effects and impair bone resorption.
Source: British Journal of Pharmacology - January 28, 2013 Category: Drugs & Pharmacology Authors: P P C Souza, A B Brechter, R I Reis, C A S Costa, P Lundberg, U H Lerner Tags: Research Paper Source Type: research
Inhibition Of Fatty Acid Amide Hydrolase Activates Nrf2 Signaling And Induces Heme Oxygenase 1 Transcription In Breast Cancer Cells
Conclusions and ImplicationsThese data uncovered a novel mechanism by which inhibition of FAAH or exposure to AEA induced HO‐1 transcripts and implicating AEA and FAAH as direct modifiers in signaling mediated activation of Nrf2‐HO‐1 pathway, independent of cannabinoid receptors.
Source: British Journal of Pharmacology - January 24, 2013 Category: Drugs & Pharmacology Authors: H Li, JT Wood, KM Whitten, SK Vadival, S Seng, A Makriyannis, S Avraham, HK Avraham Tags: Research Paper Source Type: research
Glycogen synthase kinase‐3 (GSK‐3) regulates TGF‐β1‐induced differentiation of pulmonary fibroblasts
Conclusion and implicationWe demonstrate that GSK‐3 signaling regulates TGF‐β1‐induced myofibroblast differentiation by regulating CREB phosphorylation. GSK‐3 may constitute a useful target for treatment of chronic lung diseases.
Source: British Journal of Pharmacology - January 9, 2013 Category: Drugs & Pharmacology Authors: Hoeke A. Baarsma, Lilian H.J.M Engelbertink, Lonneke J. Hees, Mark H. Menzen, Herman Meurs, Wim Timens, Dirkje S. Postma, Huib A.M. Kerstjens, Reinoud Gosens Tags: Research Paper Source Type: research
