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Source: British Journal of Pharmacology
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Total 109 results found since Jan 2013.
PAR1‐dependent COX‐2/PGE2 production contributes to cell proliferation via EP2 receptors in primary human cardiomyocytes
Conclusions and ImplicationsThese findings demonstrate that MAPKs‐mediated activation of AP‐1/NF‐κB pathways is, at least in part, required for COX‐2/PGE2/EP2‐triggered cell proliferation in human cardiomyocytes.
Source: British Journal of Pharmacology - September 5, 2014 Category: Drugs & Pharmacology Authors: Peter Tzu‐Yu Chien, Hsi‐Lung Hsieh, Pei‐Ling Chi, Chuen‐Mao Yang Tags: Research Paper Source Type: research
Oxidized LDL‐induced angiogenesis involves sphingosine‐1‐phosphate. Prevention by anti‐S1P antibody
Conclusion and ImplicationsThese data emphasize the role of S1P in angiogenesis induced by oxLDL both in HMEC‐1 cultured on Matrigel and in vivo in the Matrigel plug model in mice, and the efficacy of the anti‐S1P antibody in blocking the angiogenic effect of oxLDL.
Source: British Journal of Pharmacology - September 1, 2014 Category: Drugs & Pharmacology Authors: Caroline Camaré, Magali Trayssac, Barbara Garmy‐Susini, Elodie Mucher, Roger Sabbadini, Robert Salvayre, Anne Negre‐Salvayre Tags: Research Paper Source Type: research
The ceramide kinase inhibitor NVP‐231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death
Conclusions and implicationsOur data demonstrate for the first time a crucial role of CerK in the M phase control in cancer cells and suggests the value of its targeted inhibition using NVP‐231 in combination with conventional proapoptotic chemotherapy.
Source: British Journal of Pharmacology - August 21, 2014 Category: Drugs & Pharmacology Authors: Oleksandr Pastukhov, Stephanie Schwalm, Uwe Zangemeister‐Wittke, Doriano Fabbro, Frederic Bornancin, Lukasz Japtok, Burkhard Kleuser, Josef Pfeilschifter, Andrea Huwiler Tags: Research Paper Source Type: research
Autocrine secretion of 15d‐PGJ2 mediates simvastatin induced apoptotic burst in human metastatic melanoma cells
ConclusionWe here delineate simvastatin induced activation of the 15d‐PGJ2/FABP5 signalling cascades, which trigger an apoptotic burst in melanoma cells, while primary human melanocytes were unaffected. These data support new rational ground for pharmacological targeting of 15d‐PGJ2 in metastatic melanoma.
Source: British Journal of Pharmacology - August 4, 2014 Category: Drugs & Pharmacology Authors: Christine Wasinger, Martin Künzl, Christoph Minichsdorfer, Christoph Höller, Maria Zellner, Martin Hohenegger Tags: Research Paper Source Type: research
δ‐Opioid Receptors Up‐regulate Excitatory Amino Acid Transporters in Mouse Astrocytes
Conclusions and ImplicationsDOR activation upregulates astrocytic EAATs via MEK‐ERK‐p38 signaling, suggesting a critical role of DOR in the regulation of astrocytic EAATs and neuroprotection against excitotoxic injury. Since decreased EAAT expression contributes to pathophysiology in many neurological diseases such as amyotrophic lateral sclerosis, our findings present a new platform for potential treatments of these diseases.
Source: British Journal of Pharmacology - July 23, 2014 Category: Drugs & Pharmacology Authors: Jianfeng Liang, Dongman Chao, Harleen K Sandhu, Yanbing Yu, Li Zhang, Gianfranco Balboni, Dong H Kim, Ying Xia Tags: Research Paper Source Type: research
TRPC6 regulates cell cycle progression by modulating membrane potential in bone marrow stromal cells
Conclusions and implicationsTRPC6 plays a pivotal role in controlling the SOCE magnitude through membrane potential changes, which is critical for cell cycle progression of BMSCs. This finding provides a new therapeutic strategy to regulate BMSC proliferation.
Source: British Journal of Pharmacology - July 9, 2014 Category: Drugs & Pharmacology Authors: Jun Ichikawa, Ryuji Inoue Tags: Research Paper Source Type: research
DMH1 (4‐6‐(4‐Isopropoxyphenyl)pyrazolo 1,5‐apyrimidin‐3‐yl quinoline) is a novel autophagy inhibitor
Conclusion And ImplicationsDMH1 inhibits cell autophagy responses and the underlying mechanism involves activation of Akt pathway.
Source: British Journal of Pharmacology - June 19, 2014 Category: Drugs & Pharmacology Authors: Yue Sheng, Bo Sun, Wen‐Ting Guo, Xiao Liu, Yu‐Chun Wang, Xin Xie, Xiao‐Lin Xiao, Na Li, De‐Li Dong Tags: Research Paper Source Type: research
Integrin β3 mediates cerebrovascular remodelling through Src/ClC‐3 volume‐regulated Cl− channel signalling pathway
Conclusions and ImplicationsIntegrin β3 mediates cerebrovascular remodelling during hypertension via Src/ClC‐3 signalling pathway.
Source: British Journal of Pharmacology - June 10, 2014 Category: Drugs & Pharmacology Authors: Jia‐Wei Zeng, Xiao‐Guang Wang, Ming‐Ming Ma, Xiao‐Fei Lv, Jie Liu, Jia‐Guo Zhou, Yong‐Yuan Guan Tags: RESEARCH PAPER Source Type: research
JAK2/STAT5/Bcl‐xL signalling is essential for erythropoietin‐mediated protection against apoptosis induced in PC12 cells by the amyloid β−peptide Aβ25–35
Conclusions and ImplicationsEPO protected PC12 cells against Aβ25–35‐induced neurotoxicity. Activation of JAK2/STAT5/Bcl‐xL pathway was important in EPO‐mediated neuroprotection. EPO may serve as a novel protective agent against Aβ25–35‐induced cytotoxicity in, for instance, Alzheimer's disease.
Source: British Journal of Pharmacology - June 10, 2014 Category: Drugs & Pharmacology Authors: Rong Ma, Jing Hu, Chengfang Huang, Min Wang, Jizhou Xiang, Gang Li Tags: RESEARCH PAPER Source Type: research
Reactive oxygen species induce MMP12‐dependent degradation of collagen 5 and fibronectin to promote the motility of human umbilical cord‐derived mesenchymal stem cells
Conclusions and ImplicationsH2O2 stimulated UCB‐MSCs motility by increasing MMP12‐dependent degradation of COL‐5 and FN through the activation of NF‐κB and glycogen synthase kinase‐3β/β‐catenin, which is critical for providing a suitable microenvironment for MSCs transplantation and re‐epithelialization of skin wounds in mice.
Source: British Journal of Pharmacology - June 10, 2014 Category: Drugs & Pharmacology Authors: Seung Pil Yun, Sei‐Jung Lee, Sang Yub Oh, Young Hyun Jung, Jung Min Ryu, Han Na Suh, Mi Ok Kim, Keon Bong Oh, Ho Jae Han Tags: RESEARCH PAPER Source Type: research
Quercetin Attenuates Doxorubicin Cardiotoxicity by Modulating Bmi‐1 Expression
Conclusions And ImplicationsOur results demonstrate that QCT abrogates Dox‐induced cardiotoxicity in vitro and in vivo by reducing oxidative stress by upregulation of Bmi‐1 expression. The novel findings presented in this study have potential applications in preventing Dox‐induced cardiomyopathy.
Source: British Journal of Pharmacology - June 5, 2014 Category: Drugs & Pharmacology Authors: Qinghua Dong, Long Chen, Qunwei Lu, Sherven Sharma, Lei Li, Sachio Morimoto, Guanyu Wang Tags: Research Paper Source Type: research
PAR‐1‐dependent COX‐2/PGE2 production contributes to cell proliferation via EP2 in primary human cardiomyocytes
Conclusions And ImplicationsThese findings demonstrate that MAPKs‐mediated activation of AP‐1/NF‐κB pathways is, at least in part, required for COX‐2/PGE2/EP2‐triggered cell proliferation in human cardiomyocytes.
Source: British Journal of Pharmacology - June 5, 2014 Category: Drugs & Pharmacology Authors: Peter Tzu‐Yu Chien, Hsi‐Lung Hsieh, Pei‐Ling Chi, Chuen‐Mao Yang Tags: Research Paper Source Type: research
PPARβ activation restores the high glucose‐induced impairment of insulin signalling in endothelial cells
Conclusion and ImplicationsPPARβ activation in vitro and in vivo restores the endothelial function, preserving the insulin‐Akt‐eNOS pathway impaired by high glucose, at least in part, through PDK4 activation.
Source: British Journal of Pharmacology - May 27, 2014 Category: Drugs & Pharmacology Authors: A M Quintela, R Jiménez, L Piqueras, M Gómez‐Guzmán, J Haro, M J Zarzuelo, A Cogolludo, M J Sanz, M Toral, M Romero, F Pérez‐Vizcaíno, J Duarte Tags: RESEARCH PAPER Source Type: research
Naringenin inhibits the growth of Dictyostelium and MDCK‐derived cysts in a TRPP2 (polycystin‐2)‐dependent manner
Conclusions and ImplicationsThe action of naringenin on cell growth in the phylogenetically diverse systems of Dictyostelium and mammalian kidney cells, suggests a conserved effect mediated by TRPP2 (polycystin‐2). Further studies will investigate naringenin as a potential new therapeutic agent in ADPKD.
Linked ArticlesThis article is part of a themed section on the pharmacology of TRP channels. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue‐10
Source: British Journal of Pharmacology - April 28, 2014 Category: Drugs & Pharmacology Authors: A Waheed, M H R Ludtmann, N Pakes, S Robery, A Kuspa, C Dinh, D Baines, R S B Williams, M A Carew Tags: Research Paper Source Type: research
The TRPC channel blocker SKF 96365 Inhibits Glioblastoma Cell Growth by Enhancing Reverse Mode of the Na+/Ca2+ Exchanger and Increasing Intracellular Ca2+
Conclusions and ImplicationsAt the same concentration that blocks TRPC channels, SKF 96365 enhances the reverse mode of the NCX that causes [Ca2+]i accumulation and cytotoxicity. This finding suggests an alternative pharmacological mechanism of SKF 96365. It also indicates that modulation of the NCX is an efficacious way to disrupt Ca2+ homeostasis and supress human glioblastoma cells.
Source: British Journal of Pharmacology - March 18, 2014 Category: Drugs & Pharmacology Authors: M Song, D Chen, S P Yu Tags: Research Paper Source Type: research
