JAK2/STAT5/Bcl‐xL signalling is essential for erythropoietin‐mediated protection against apoptosis induced in PC12 cells by the amyloid β−peptide Aβ25–35

Conclusions and ImplicationsEPO protected PC12 cells against Aβ25–35‐induced neurotoxicity. Activation of JAK2/STAT5/Bcl‐xL pathway was important in EPO‐mediated neuroprotection. EPO may serve as a novel protective agent against Aβ25–35‐induced cytotoxicity in, for instance, Alzheimer's disease.
Source: British Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: RESEARCH PAPER Source Type: research