PAR‐1‐dependent COX‐2/PGE2 production contributes to cell proliferation via EP2 in primary human cardiomyocytes

Conclusions And ImplicationsThese findings demonstrate that MAPKs‐mediated activation of AP‐1/NF‐κB pathways is, at least in part, required for COX‐2/PGE2/EP2‐triggered cell proliferation in human cardiomyocytes.

Source: British Journal of Pharmacology - June 5, 2014 Category: Drugs & Pharmacology Authors: Peter Tzu‐Yu Chien, Hsi‐Lung Hsieh, Pei‐Ling Chi, Chuen‐Mao Yang Tags: Research Paper Source Type: research