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Source: British Journal of Pharmacology
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Total 109 results found since Jan 2013.
Effects of corilagin on alleviating cholestasis via farnesoid X receptor ‐associated pathways in vitro and in vivo
Conclusions and ImplicationsCorilagin exerts a protective effect in hepatocytes and can prevent the deleterious activities of intrahepatic cholestasis by stimulating FXR‐associated pathways.
Source: British Journal of Pharmacology - January 25, 2018 Category: Drugs & Pharmacology Authors: Fan Yang, Yao Wang, Gang Li, Juan Xue, Zhi ‐Lin Chen, Feng Jin, Lei Luo, Xuan Zhou, Qian Ma, Xin Cai, Hua‐Rong Li, Lei Zhao Tags: RESEARCH PAPER Source Type: research
Expression, distribution and function of kinin B1 receptor in the rat diabetic retina
Conclusion and ImplicationsThis study supports a detrimental role for kinin B1R on endothelial and glial cells in acute and advanced phases of DR. Topical application of the peptide kinin B1R antagonist R‐954 appears a feasible therapeutic approach in the treatment of DR.
Source: British Journal of Pharmacology - December 29, 2017 Category: Drugs & Pharmacology Authors: Soumaya Hachana, Menakshi Bhat, Jacques S énécal, Frédéric Huppé‐Gourgues, Réjean Couture, Elvire Vaucher Tags: RESEARCH PAPER Source Type: research
Effects of corilagin on alleviating cholestasis via FXR ‐associated pathways in vitro and in vivo
CONCLUSIONS AND IMPLICATIONSCorilagin exerts a protective effect in hepatocytes and can rescue the deleterious activities of intrahepatic cholestasis by stimulating FXR‐associated pathways.
Source: British Journal of Pharmacology - December 1, 2017 Category: Drugs & Pharmacology Authors: Fan Yang, Yao Wang, Gang Li, Juan Xue, Zhi ‐Lin Chen, Feng Jin, Lei Luo, Xuan Zhou, Qian Ma, Xin Cai, Hua‐Rong Li, Lei Zhao Tags: RESEARCH PAPER Source Type: research
G α12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3‐kinase‐mediated activation in a RhoA‐dependent manner
Conclusions and ImplicationsGα12 plays a crucial role in HASMC contraction via RhoA‐dependent activation of the PI3K/ROCK axis. Inhibition of RhoA activation induces bronchodilation in hPCLS, and targeting Gα12 signaling may elucidate novel therapeutic targets in asthma. These findings provide alternative approaches to the clinical management of airway obstruction in asthma.
Source: British Journal of Pharmacology - November 12, 2017 Category: Drugs & Pharmacology Authors: Edwin J Yoo, Gaoyuan Cao, Cynthia J Koziol ‐White, Christie A Ojiaku, Krishna Sunder, Joseph A Jude, James V Michael, Hong Lam, Ivan Pushkarsky, Robert Damoiseaux, Dino Di Carlo, Kwangmi Ahn, Steven S An, Raymond B Penn, Reynold A Panettieri Tags: RESEARCH PAPER Source Type: research
GPR35 mediates lodoxamide ‐induced migration inhibitory response but not CXCL17‐induced migration stimulatory response in THP‐1 cells; Is GPR35 a receptor for CXCL17?
Abstract
GPR35 has long been considered an orphan G protein‐couple receptor, and although no endogenous ligand of GPR35 has been discovered, synthetic agonists and antagonists have been developed. CXCL17 (a chemokine) has been reported to be an endogenous ligand of GPR35, and it has even been suggested that it be called CXCR8 (Journal of Immunology 2015; 194:29‐33). However, no supporting report on the CXCL17‐GPR35 relation has been issued since, although GPR35 is supposed to be a potential therapeutic target in several pathologic conditions. In the present study, we applied two assay systems to explore the relations...
Source: British Journal of Pharmacology - October 25, 2017 Category: Drugs & Pharmacology Authors: Soo ‐Jin Park, Seung‐Jin Lee, So‐Yeon Nam, Dong‐Soon Im Tags: RESEARCH PAPER Source Type: research
G α12 Facilitates Carbachol‐Induced Shortening in Human Airway Smooth Muscle By Modulating Phosphoinositide 3‐Kinase‐Mediated Activation In A RhoA‐Dependent Manner
CONCLUSION AND IMPLICATIONSGα12 plays a crucial role in HASMC contraction via RhoA‐dependent activation of the PI3K/ROCK axis. Inhibition of RhoA activation induces bronchodilation in hPCLS, and targeting Gα12 signaling may elucidate novel therapeutic targets in asthma. Taken together, these findings provide alternative approaches to the clinical management of airway obstruction in asthma.
Source: British Journal of Pharmacology - September 18, 2017 Category: Drugs & Pharmacology Authors: Edwin J Yoo, Gaoyuan Cao, Cynthia J Koziol ‐White, Christie A Ojiaku, Krishna Sunder, Joseph A Jude, James V Michael, Hong Lam, Ivan Pushkarsky, Robert Damoiseaux, Dino Di Carlo, Kwangmi Ahn, Steven S An, Raymond B Penn, Reynold A Panettieri Tags: RESEARCH PAPER Source Type: research
WMJ ‐8‐B, a novel hydroxamate derivative, induces MDA‐MB‐231 breast cancer cell death via SHP‐1‐STAT3‐survivin cascade
Conclusions and ImplicationsWMJ‐8‐B‐induced MDA‐MB‐231 breast cancer cell death involves SHP‐1‐STAT3‐survivin and Sp1‐p21 cascades. These results also support the role of WMJ‐8‐B as a potential lead compound and warrant the clinical development in the treatment of breast cancer.
Source: British Journal of Pharmacology - June 23, 2017 Category: Drugs & Pharmacology Authors: Yu ‐Fan Chuang, Shiu‐Wen Huang, Ya‐Fen Hsu, Meng‐Chieh Yu, George Ou, Wei‐Jan Huang, Ming‐Jen Hsu Tags: RESEARCH PAPER Source Type: research
Recent Advances in the Development of T ‐type Calcium Channel Blockers for Pain Intervention
Abstract
Cav3.2 T‐type calcium channels are important regulators of pain signals in afferent pain pathway, and their activities are dysregulated during various chronic pain states. Therefore it stands to reason that inhibiting T‐type calcium channels in dorsal root ganglion neurons and in the spinal dorsal horn can be targeted for pain relief. This is supported by early pharmacological studies with T‐type channel blockers such as ethosuximide, and by analgesic effects of siRNA depletion of Cav3.2 channels. In the past five years, considerable effort has been applied towards identifying novel classes of T‐type calci...
Source: British Journal of Pharmacology - June 13, 2017 Category: Drugs & Pharmacology Authors: Terrance P Snutch, Gerald W Zamponi Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
The isoprenoid derivative N6 ‐benzyladenosine CM223 exerts antitumor effects in glioma patient‐derived primary cells through the mevalonate pathway
Conclusion and ImplicationsThe biological effects together with structural data on interaction of CM223 with FPPS, provided additional evidence for the correlation of the i6A/CM223 antitumor activity with FPPS modulation. Because the MVA pathway is an important promising target, CM223 and its derivatives should be considered interesting active molecules in antiglioma research.
Source: British Journal of Pharmacology - June 11, 2017 Category: Drugs & Pharmacology Authors: Elena Ciaglia, Manuela Grimaldi, Mario Abate, Mario Scrima, Manuela Rodriquez, Chiara Laezza, Roberta Ranieri, Simona Pisanti, Pierangela Ciuffreda, Clementina Manera, Patrizia Gazzerro, Anna Maria D'Ursi, Maurizio Bifulco Tags: RESEARCH PAPER Source Type: research
Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3 dependent manner
CONCLUSION AND IMPLICATIONS
NaHS improved mitochondrial function and inhibited oxidative stress in myocardial hypertrophy via a SIRT3 dependent manner.
Source: British Journal of Pharmacology - May 15, 2017 Category: Drugs & Pharmacology Authors: Guoliang Meng, Jieqiong Liu, Shangmin Liu, Qiuyi Song, Lulu Liu, Liping Xie, Yi Han, Yong Ji Tags: RESEARCH PAPER THEMED ISSUE Source Type: research
The isoprenoid derivative N6 ‐benzyladenosine (CM223) exerts antitumor effect in glioma patient‐derived primary cells through the mevalonate pathway.
Conclusion and ImplicationsThis biological effect together with structural data on interaction of CM223 with FPPS, gain additional evidence on the correlation of the i6A/CM223 antitumoral activity with FPPS modulation. Because the MVA pathway is becoming an important promising target, CM223 and derivatives should be considered interesting active molecules in antiglioma pharmacological research.
Source: British Journal of Pharmacology - April 18, 2017 Category: Drugs & Pharmacology Authors: Elena Ciaglia, Manuela Grimaldi, Mario Abate, Mario Scrima, Manuela Rodriquez, Chiara Laezza, Roberta Ranieri, Simona Pisanti, Pierangela Ciuffreda, Clementina Manera, Patrizia Gazzerro, Anna Maria D'Ursi, Maurizio Bifulco Tags: RESEARCH PAPER Source Type: research
Protein phosphatase 2A regulation of markers of extracellular matrix remodelling in hepatocellular carcinoma cells: functional consequences for tumour invasion
Conclusion and ImplicationsOA increased MMP‐9 by decreasing PP2A activity and PP2Ac, through AP‐1 binding sites on the MMP‐9 promoter. The functional consequence of this and CIP2A overexpression was increased cell migration. Hence, PP2A inhibition induced a metastatic phenotype through alterations in MMP‐9 in Hep3B cells.
Source: British Journal of Pharmacology - April 7, 2017 Category: Drugs & Pharmacology Authors: M P Ward, J P Spiers Tags: RESEARCH PAPER Source Type: research
Inhibition of 6 ‐phosphofructo‐2‐kinase suppresses fibroblast‐like synoviocytes‐mediated synovial inflammation and joint destruction in rheumatoid arthritis
Conclusion and ImplicationsElevated PFKFB3 expression might contribute to synovial inflammation and aggressive behaviours of RA FLSs, suggesting a novel strategy of targeting PFKFB3 to prevent synovial inflammation and joint destruction in RA.
Source: British Journal of Pharmacology - March 27, 2017 Category: Drugs & Pharmacology Authors: Yaoyao Zou, Shan Zeng, Mingcheng Huang, Qian Qiu, Youjun Xiao, Maohua Shi, Zhongping Zhan, Liuqin Liang, Xiuyan Yang, Hanshi Xu Tags: RESEARCH PAPER Source Type: research
Signalling Mechanisms Underlying Doxorubicin And Nox2 Nadph Oxidase ‐Induced Cardiomyopathy: Involvement Of Mitofusin‐2
Conclusions and implicationsDOX‐induced and Nox2‐mediated upregulation of Mfn2, rather than contributing to cardiomyocyte dysfunction through apoptotic pathways, appears to promote a protective mechanism.
Source: British Journal of Pharmacology - March 5, 2017 Category: Drugs & Pharmacology Authors: Declan McLaughlin, Youyou Zhao, Karla M O'Neill, Kevin S Edgar, Philip D Dunne, Anna M Kearney, David J Grieve, Barbara J McDermott Tags: RESEARCH PAPER THEMED ISSUE Source Type: research
Inhibition of 6 ‐phosphofructo‐2‐kinase suppresses fibroblast‐like synoviocytes‐ mediated synovial inflammation and joint destruction in rheumatoid arthritis
Conclusion And ImplicationsElevated PFKFB3 expression might contribute to synovial inflammation and aggressive behaviors of RA FLSs, suggesting a novel strategy of targeting PFKFB3 to prevent synovial inflammation and joint destruction in RA.
Source: British Journal of Pharmacology - February 27, 2017 Category: Drugs & Pharmacology Authors: Yaoyao Zou, Shan Zeng, Mingcheng Huang, Qian Qiu, Youjun Xiao, Maohua Shi, Zhongping Zhan, Liuqin Liang, Xiuyan Yang, Hanshi Xu Tags: RESEARCH PAPER Source Type: research
