Metformin attenuates angiotensin II ‐induced TGFβ1 expression by targeting hepatocyte nuclear factor 4α

Conclusions and ImplicationsHNF4α mediated AngII‐induced TGFβ1 transcription and cardiac fibrosis. Metformin inhibited AngII‐induced HNF4α expression via AMPK activation, thus decreasing TGFβ1 transcription and cardiac fibrosis. These findings reveal a novel antifibrotic mechanism of action of metformin and identify HNF4α as a new potential therapeutic target for cardiac fibrosis.

Source: British Journal of Pharmacology - February 23, 2017 Category: Drugs & Pharmacology Authors: Ruifei Chen, Yenan Feng, Jimin Wu, Yao Song, Hao Li, Qiang Shen, Dan Li, Jianshu Zhang, Zhizhen Lu, Han Xiao, Youyi Zhang Tags: RESEARCH PAPER THEMED ISSUE Source Type: research