Apelin‐13 administration protects against ischemia/reperfusion‐mediated apoptosis through FoxO1 pathway in high‐fat diet‐induced obesity.

Conclusions and ImplicationsThese data uncover apelin as a novel regulator of FoxO1 in cardiac cells and provide the evidence for the potential of apelin‐13 in prevention of apoptosis and mitochondrial damage in conditions combining I/R injury and obesity.

Source: British Journal of Pharmacology - March 23, 2016 Category: Drugs & Pharmacology Authors: Frederic Boal, Andrei Timotin, Jessica Roumegoux, Chiara Alfarano, Denis Calise, Rodica Anesia, Angelo Parini, Philippe Valet, Helene Tronchere, Oksana Kunduzova Tags: Research Paper Source Type: research