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Source: Cancer Science
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Total 106 results found since Jan 2013.
Cancer with low cathepsin D levels is susceptible to V ‐ATPase inhibition
This article is protected by copyright. All rights reserved.
Source: Cancer Science - January 31, 2017 Category: Cancer & Oncology Authors: Satoshi Kitazawa, Satoru Nishizawa, Hideyuki Nakagawa, Masaaki Funata, Kazuho Nishimura, Tomoyoshi Soga, Takahito Hara Tags: Original Article Source Type: research
miR ‐9 plays a role in IL‐10‐mediated expression of E‐cadherin in acute myelogenous leukemia cells
This article is protected by copyright. All rights reserved.
Source: Cancer Science - January 19, 2017 Category: Cancer & Oncology Authors: Chie Nishioka, Takayuki Ikezoe, Bin Pan, Kailin Xu, Akihito Yokoyama Tags: Original Article Source Type: research
EphB3 ‐targeted regulation of miR‐149 in the migration and invasion of human colonic carcinoma HCT116 and SW620 cells
In conclusion,the important role of miR‐149 in colorectal cancer progression suggesting that miR‐149 may serve as a therapeutic target for colorectal cancer treatment.
This article is protected by copyright. All rights reserved.
Source: Cancer Science - January 10, 2017 Category: Cancer & Oncology Authors: Guodong Zhang, Xiaozhu Liu, Yinfeng Li, Yan wang, Huankun Liang, Kangyan Li, Laiqing Li, Cuicui Chen, Wenqiao Sun, Shoulei Ren, Pengfei Zhu, Licheng Zhang Tags: Original Article Source Type: research
The long noncoding RNA SchLAH suppresses metastasis of hepatocellular carcinoma through interacting with FUS
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Source: Cancer Science - December 31, 2016 Category: Cancer & Oncology Authors: Zhouhong Ge, Zhuoan Cheng, Xinrong Yang, Xisong Huo, Ning Wang, Hui Wang, Cun Wang, Dishui Gu, Fangyu Zhao, Ming Yao, Jia Fan, Wenxin Qin Tags: Original Article Source Type: research
Downregulation of miR ‐100/miR‐125b is associated with lymph node metastasis in early colorectal cancer with submucosal invasion
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Source: Cancer Science - December 28, 2016 Category: Cancer & Oncology Authors: Yasuteru Fujino, Shunsaku Takeishi, Kensei Nishida, Koichi Okamoto, Naoki Muguruma, Tetsuo Kimura, Shinji Kitamura, Hiroshi Miyamoto, Akiko Fujimoto, Jun Higashijima, Mitsuo Shimada, Kazuhito Rokutan, Tetsuji Takayama Tags: Original Article Source Type: research
Activation of Matrix Metalloproteinase (MMP) ‐9 by Membrane‐Type‐1 Matrix Metalloproteinase/MMP‐2 axis Stimulates Tumor Metastasis
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Source: Cancer Science - December 16, 2016 Category: Cancer & Oncology Authors: Zichen Li, Takahisa Takino, Yoshio Endo, Hiroshi Sato Tags: Original Article Source Type: research
A leukemogenic kinase, FIP1L1 ‐PDGFRA, and a SUMO E3 ligase, PIAS1, form a positive crosstalk via their enzymatic activities
In conclusion, our results suggest that sumoylation by PIAS1 is a potential target in the treatment of FIP1L1‐PDGFRA‐positive chronic eosinophilic leukemia.
This article is protected by copyright. All rights reserved.
Source: Cancer Science - December 12, 2016 Category: Cancer & Oncology Authors: Makoto Ibata, Junko Iwasaki, Yoichiro Fujioka, Koji Nakagawa, Stephanie Darmanin, Masahiro Onozawa, Daigo Hashimoto, Yusuke Ohba, Shigetsugu Hatakeyama, Takanori Teshima, Takeshi Kondo Tags: Original Article Source Type: research
Impact of Sulfatase ‐2 on cancer progression and prognosis in patients with renal cell carcinoma
Heparan sulfate‐specific endosulfatase‐2 (SULF‐2) can modulate the signaling of heparan sulfate proteoglycan‐binding proteins. The involvement of SULF‐2 in cancer growth varies by cancer type. The roles of SULF‐2 expression in the progression and prognosis of renal cell carcinomas (RCC) have not yet been fully clarified. In the present study, the expression levels of SULF‐2 mRNA and protein in 49 clinical RCC samples were determined by RT‐PCR and immunostaining. The existence of RCC with higher SULF‐2 expression and lower SULF‐2 expression compared to the adjacent normal kidney tissues was suggested. Hi...
Source: Cancer Science - November 28, 2016 Category: Cancer & Oncology Authors: Shin Kumagai, Kei Ishibashi, Masao Kataoka, Toshiki Oguro, Yuichirou Kiko, Tomohiko Yanagida, Ken Aikawa, Yoshiyuki Kojima Tags: Original Article Source Type: research
Metformin inhibits estrogen ‐dependent endometrial cancer cell growth by activating the AMPK–FOXO1 signal pathway
This study provide a novel mechanism of anti‐neoplastic effect for metformin through the regulation of FOXO1, and suggest that AMPK‐FOXO1 pathway may be a therapeutic target to the development of new anti‐neoplastic drugs.
Source: Cancer Science - November 24, 2016 Category: Cancer & Oncology Authors: Jingfang Zou, Liangli Hong, Chaohuan Luo, Zhi Li, Yuzhang Zhu, Tianliang Huang, Yongneng Zhang, Huier Yuan, Yaqiu Hu, Tengfei Wen, Wanling Zhuang, Bozhi Cai, Xin Zhang, Jiexiong Huang, Jidong Cheng Tags: Original Article Source Type: research
High KRT8 expression promotes tumor progression and metastasis of Gastric Cancer
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Source: Cancer Science - September 30, 2016 Category: Cancer & Oncology Authors: Fang Jian, Wang Hao, Liu Yun, Ding Fangfang, Ni Ying, Shao Shihe Tags: Original Article Source Type: research
Metformin inhibits estrogen ‐dependent endometrial cancer cell growth by activating the AMPK‐FOXO1 signal pathway
This article is protected by copyright. All rights reserved.
Source: Cancer Science - September 15, 2016 Category: Cancer & Oncology Authors: Jingfang Zou, Liangli Hong, Chaohuan Luo, Zhi Li, Yuzhang Zhu, Tianliang Huang, Yongneng Zhang, Huier Yuan, Yaqiu Hu, Tengfei Wen, Wanling Zhuang, Bozhi Cai, Xin Zhang, Jiexiong Huang, Jidong Cheng Tags: Original Article Source Type: research
Dual tumor ‐suppressors miR‐139‐5p and miR‐139‐3p targeting matrix metalloprotease 11 in bladder cancer
Our recent study of the microRNA (miRNA) expression signature of bladder cancer (BC) by deep‐sequencing revealed that two miRNA, microRNA‐139‐5p/microRNA‐139‐3p were significantly downregulated in BC tissues. The aim of this study was to investigate the functional roles of these miRNA and their modulation of cancer networks in BC cells. Functional assays of BC cells were performed using transfection of mature miRNA or small interfering RNA (siRNA). Genome‐wide gene expression analysis, in silico analysis and dual‐luciferase reporter assays were applied to identify miRNA targets. The associations between the e...
Source: Cancer Science - September 5, 2016 Category: Cancer & Oncology Authors: Masaya Yonemori, Naohiko Seki, Hirofumi Yoshino, Ryosuke Matsushita, Kazutaka Miyamoto, Masayuki Nakagawa, Hideki Enokida Tags: Original Article Source Type: research
The impact of Sulfatase ‐2 on cancer progression and prognosis in patients with renal cell carcinoma
This article is protected by copyright. All rights reserved.
Source: Cancer Science - September 1, 2016 Category: Cancer & Oncology Authors: Shin Kumagai, Kei Ishibashi, Masao Kataoka, Toshiki Oguro, Yuichirou Kiko, Tomohiko Yanagida, Ken Aikawa, Yoshiyuki Kojima Tags: Original Article Source Type: research
A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor
This article is protected by copyright. All rights reserved.
Source: Cancer Science - August 31, 2016 Category: Cancer & Oncology Authors: Yuta Yamada, Ken ‐ichi Takayama, Tetsuya Fujimura, Daisaku Ashikari, Daisuke Obinata, Satoru Takahashi, Kazuhiro Ikeda, Shigenori Kakutani, Tomohiko Urano, Hiroshi Fukuhara, Yukio Homma, Satoshi Inoue Tags: Original Article Source Type: research
Inhibiting Autophagy Increases Epirubicin's Cytotoxicity in Breast Cancer Cells
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Source: Cancer Science - August 24, 2016 Category: Cancer & Oncology Authors: Wei Guo, Yu Wang, Zhu Wang, Yan ‐Ping Wang, Hong Zheng Tags: Original Article Source Type: research
