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Source: Cancer Science
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Total 106 results found since Jan 2013.
High ‐mobility group box‐1 contributes tumor angiogenesis under interleukin‐8 mediation during gastric cancer progression
This article is protected by copyright. All rights reserved.
Source: Cancer Science - June 2, 2017 Category: Cancer & Oncology Authors: Hye Won Chung, Jong ‐Baeck Lim Tags: Original Article Source Type: research
BRAF mutations are associated with increased iron regulatory protein ‐2 expression in colorectal tumorigenesis
A role for iron in carcinogenesis is supported by evidence that iron metabolism proteins are modulated in cancer progression. To date, however, the expression of iron regulatory protein‐2 (IRP2), which is known to regulate several iron metabolism proteins, has not been assessed in colorectal cancer. Expression of IRP2 was assessed by quantitative RT‐PCR and immunohistochemistry in human colorectal cancer tissue. By interrogating The Cancer Genome Atlas (TCGA) database, expression of IRP2 and transferrin receptor‐1 (TfR1) was assessed relative to common mutations that are known to occur in cancer. The impact of suppre...
Source: Cancer Science - June 2, 2017 Category: Cancer & Oncology Authors: Richard D. Horniblow, Matthew Bedford, Robert Hollingworth, Sarah Evans, Emily Sutton, Neeraj Lal, Andrew Beggs, Tariq H. Iqbal, Chris Tselepis Tags: Original Article Source Type: research
Cancer with low cathepsin D levels is susceptible to vacuolar (H+) ‐ATPase inhibition
In this study, we explored markers of V‐ATPase inhibitor sensitivity. V‐ATPase inhibitors led to pH impairment in acidic intracellular compartments, suppression of macropinocytosis, and decreased intracellular amino acid levels. The sensitivity of cells to V‐ATPase inhibitors was correlated with low cathepsin D expression, and cancer cells showed increased sensitivity to V‐ATPase inhibitors after pretreatment with a cathepsin D inhibitor and siRNA targeting the cathepsin D gene (CTSD). In addition, V‐ATPase inhibitor treatment led to the induction of the amino acid starvation response, upregulation of endoplasmic...
Source: Cancer Science - May 20, 2017 Category: Cancer & Oncology Authors: Satoshi Kitazawa, Satoru Nishizawa, Hideyuki Nakagawa, Masaaki Funata, Kazuho Nishimura, Tomoyoshi Soga, Takahito Hara Tags: Original Article Source Type: research
Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis
It is well known that comedo necrosis is closely associated with an aggressive phenotype of ductal carcinoma in situ (DCIS) of human breast, but its molecular mechanisms remain largely unclear. Therefore, in this study, we first examined the gene expression profile of comedo DCIS based on microarray data and identified CYC1 as a gene associated with comedo necrosis. Cytochrome c1 (CYC1) is a subunit of complex III in the mitochondrial oxidative phosphorylation that is involved in energy production. However, the significance of CYC1 has not yet been examined in DCIS. We therefore immunolocalized CYC1 in 47 DCIS cases. CYC1 ...
Source: Cancer Science - May 19, 2017 Category: Cancer & Oncology Authors: Mayuko Chishiki, Kiyoshi Takagi, Ai Sato, Yasuhiro Miki, Yuta Yamamoto, Akiko Ebata, Yukiko Shibahara, Mika Watanabe, Takanori Ishida, Hironobu Sasano, Takashi Suzuki Tags: Original Article Source Type: research
SAHA sensitizes neuroblastoma to paclitaxel by inhibiting TRP14 ‐mediated autophagy
This study explored the regulatory mechanism of paclitaxel‐associated autophagy and potential solutions to paclitaxel resistance in neuroblastoma. The formation of autophagic vesicles was detected by scanning transmission electron microscopy and flow cytometry. The autophagy‐associated proteins were assessed by western blot. Autophagy was induced and the autophagy‐associated proteins LC3‐I, LC3‐II, Beclin 1, and thioredoxin‐related protein 14 (TRP14), were found to be up‐regulated in neuroblastoma cells that were exposed to paclitaxel. The inhibition of Beclin 1 or TRP14 by siRNA increased the sensitivity of ...
Source: Cancer Science - May 12, 2017 Category: Cancer & Oncology Authors: Zijun Zhen, Kaibin Yang, Litong Ye, Zhiyao You, Rirong Chen, Ying Liu, Youjian He Tags: Original Article Source Type: research
p62/SQSTM1 as an oncotarget mediates cisplatin resistance through activating RIP1 ‐NF‐κB pathway in human ovarian cancer cells
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Source: Cancer Science - May 12, 2017 Category: Cancer & Oncology Authors: Xiao ‐Yu Yan, Yu Zhang, Juan‐Juan Zhang, Li‐Chao Zhang, Ya‐Nan Liu, Yao Wu, Ya‐Nan Xue, Sheng‐Yao Lu, Jing Su, Lian‐Kun Sun Tags: Original Article Source Type: research
MicroRNA ‐9 plays a role in interleukin‐10‐mediated expression of E‐cadherin in acute myelogenous leukemia cells
We previously showed that the CD82/signal transducer and activator of transcription/interleukin‐10 (IL‐10) axis is activated in CD34+/CD38− AML cells that favor the bone marrow microenvironment. The present study explored the novel biological function of IL‐10 in regulation of expression of adhesion molecules in AML cells and found that exposing AML cells to IL‐10 induced expression of E‐cadherin, but not other adhesion molecules, including VLA4, CD29, and LFA1. Downregulation of E‐cadherin with an siRNA suppressed the adhesion of leukemia cells to bone marrow‐derived mesenchymal stem cells and enhanced the...
Source: Cancer Science - April 20, 2017 Category: Cancer & Oncology Authors: Chie Nishioka, Takayuki Ikezoe, Bin Pan, Kailin Xu, Akihito Yokoyama Tags: Original Article Source Type: research
Long noncoding RNA SchLAH suppresses metastasis of hepatocellular carcinoma through interacting with fused in sarcoma
Emerging evidence has indicated that deregulation of long non‐coding RNAs (lncRNAs) can contribute to the progression and metastasis of human cancer, including hepatocellular carcinoma (HCC). However, the roles of most lncRNAs in HCC remain largely unknown. Here we found a long noncoding RNA termed SchLAH (seven chromosome locus associated with HCC; also called BC035072) was generally downregulated in HCC. Low expression of SchLAH was significantly correlated with shorter overall survival of HCC patients. In vitro and in vivo assays indicated that overexpression of SchLAH inhibited the migration and lung metastasis of H...
Source: Cancer Science - April 17, 2017 Category: Cancer & Oncology Authors: Zhouhong Ge, Zhuoan Cheng, Xinrong Yang, Xisong Huo, Ning Wang, Hui Wang, Cun Wang, Dishui Gu, Fangyu Zhao, Ming Yao, Jia Fan, Wenxin Qin Tags: Original Article Source Type: research
Downregulation of microRNA ‐100/microRNA‐125b is associated with lymph node metastasis in early colorectal cancer with submucosal invasion
A majority of early colorectal cancers (CRCs) with submucosal invasion undergo surgical operation, despite a very low incidence of lymph node metastasis. Our study aimed to identify microRNAs (miRNAs) specifically responsible for lymph node metastasis in submucosal CRCs. MicroRNA microarray analysis revealed that miR‐100 and miR‐125b expression levels were significantly lower in CRC tissues with lymph node metastases than in those without metastases. These results were validated by quantitative real‐time PCR in a larger set of clinical samples. The transfection of a miR‐100 or miR‐125b inhibitor into colon cancer...
Source: Cancer Science - April 3, 2017 Category: Cancer & Oncology Authors: Yasuteru Fujino, Shunsaku Takeishi, Kensei Nishida, Koichi Okamoto, Naoki Muguruma, Tetsuo Kimura, Shinji Kitamura, Hiroshi Miyamoto, Akiko Fujimoto, Jun Higashijima, Mitsuo Shimada, Kazuhito Rokutan, Tetsuji Takayama Tags: Original Article Source Type: research
Insulin ‐like growth factor‐1 signaling is responsible for cathepsin G‐induced aggregation of breast cancer MCF‐7 cells
This article is protected by copyright. All rights reserved.
Source: Cancer Science - April 1, 2017 Category: Cancer & Oncology Authors: Riyo Morimoto ‐Kamata, Satoru Yui Tags: Original Article Source Type: research
β2‐AR activation induces chemoresistance by modulating p53 acetylation through upregulating Sirt1 in cervical cancer cells
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Source: Cancer Science - April 1, 2017 Category: Cancer & Oncology Authors: Hongyu Chen, Wei Zhang, Xiang Cheng, Liang Guo, Shuai Xie, Yuanfang Ma, Ning Guo, Ming Shi Tags: Original Article Source Type: research
Activation of MMP ‐9 by membrane type‐1 MMP/MMP‐2 axis stimulates tumor metastasis
An artificial receptor for proMMP‐9 was created by fusing tissue inhibitor of MMP‐1 (TIMP‐1) with type II transmembrane mosaic serine protease (MSP‐T1). Expression of MSP‐T1 in 293T cells induced binding of proMMP‐9, which was processed by MMP‐2 activated by membrane type 1 MMP (MT1‐MMP). HT1080 cells transfected with the MSP‐T1 gene produced activated MMP‐9 in collagen gel, and addition of proMMP‐2 to the culture augmented it, which resulted in intensive collagen digestion. These cells metastasized into chick embryonic liver more than control cells. Treatment of HT1080 cells with concanavalin A in th...
Source: Cancer Science - March 15, 2017 Category: Cancer & Oncology Authors: Zichen Li, Takahisa Takino, Yoshio Endo, Hiroshi Sato Tags: Original Article Source Type: research
CYC1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis
This article is protected by copyright. All rights reserved.
Source: Cancer Science - March 1, 2017 Category: Cancer & Oncology Authors: Mayuko Chishiki, Kiyoshi Takagi, Ai Sato, Yasuhiro Miki, Yuta Yamamoto, Akiko Ebata, Yukiko Shibahara, Mika Watanabe, Takanori Ishida, Hironobu Sasano, Takashi Suzuki Tags: Original Article Source Type: research
Leukemogenic kinase FIP1L1 ‐PDGFRA and a small ubiquitin‐like modifier E3 ligase, PIAS1, form a positive cross‐talk through their enzymatic activities
In conclusion, our results suggest that sumoylation by PIAS1 is a potential target in the treatment of FIP1L1‐PDGFRA‐positive chronic eosinophilic leukemia.
A leukemogenic fusion kinase FIP1L1‐PDGFRA co‐localizes with a SUMO E3 ligase PIAS1 in nucleus. PDGFRA‐C lacking the FIP1L1 portion mainly locates in cytoplasm.
Source: Cancer Science - February 27, 2017 Category: Cancer & Oncology Authors: Makoto Ibata, Junko Iwasaki, Yoichiro Fujioka, Koji Nakagawa, Stephanie Darmanin, Masahiro Onozawa, Daigo Hashimoto, Yusuke Ohba, Shigetsugu Hatakeyama, Takanori Teshima, Takeshi Kondo Tags: Original Article Source Type: research
B ‐RAF mutations are associated with increased iron regulatory protein‐2 expression in colorectal tumourigenesis
This article is protected by copyright. All rights reserved.
Source: Cancer Science - January 31, 2017 Category: Cancer & Oncology Authors: Richard D. Horniblow, Matthew Bedford, Robert Hollingworth, Sarah Evans, Emily Sutton, Neeraj Lal, Andrew Beggs, Tariq H. Iqbal, Chris Tselepis Tags: Original Article Source Type: research
