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Source: Cancer Science
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Total 106 results found since Jan 2013.
Nek2 siRNA therapy using a portal venous port –catheter system for liver metastasis in pancreatic cancer
In this study, the overexpression of Nek2 was identified in pancreatic cancer cell lines. Nek2 siRNA inhibited tumor growth in a subcutaneous xenograft mouse model of pancreatic cancer, prolonged the survival time in an intraperitoneal xenograft mouse model and efficiently prevented the progression of liver metastasis using a portal venous port–catheter system. Taken together, Nek2 is an effective therapeutic target in pancreatic cancer. An adequate delivery system is considered important in treating advanced pancreatic cancer, such as peritoneal dissemination and liver metastasis. Further investigations are required on ...
Source: Cancer Science - August 11, 2016 Category: Cancer & Oncology Authors: Toshio Kokuryo, Shigeru Hibino, Kazushi Suzuki, Katsutaka Watanabe, Yukihiro Yokoyama, Masato Nagino, Takeshi Senga, Michinari Hamaguchi Tags: Original Article Source Type: research
Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor siRNA
Exosomes derived from cells have been found to mediate signal transduction between cells and to act as efficient carriers to deliver drugs and small RNA. Hepatocyte growth factor (HGF) is known to promote the growth of both cancer cells and vascular cells, and the HGF‐cMET pathway is a potential clinical target. Here, we characterized the inhibitory effect of HGF siRNA on tumor growth and angiogenesis in gastric cancer. In addition, we showed that HGF siRNA packed in exosomes can be transported into cancer cells, where it dramatically downregulates HGF expression. A cell co‐culture model was used to show that exosomes ...
Source: Cancer Science - February 11, 2018 Category: Cancer & Oncology Authors: Haiyang Zhang, Yi Wang, Ming Bai, Junyi Wang, Kegan Zhu, Rui Liu, Shaohua Ge, JiaLu Li, Tao Ning, Ting Deng, Qian Fan, Hongli Li, Wu Sun, Guoguang Ying, Yi Ba Tags: ORIGINAL ARTICLE Source Type: research
Exosomes Serve as Nano ‐particles to Suppress Tumor Growth and Angiogenesis in Gastric Cancer by Delivering HGF siRNA
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Source: Cancer Science - December 29, 2017 Category: Cancer & Oncology Authors: Haiyang Zhang, Yi Wang, Ming Bai, Junyi Wang, Kegan Zhu, Rui Liu, Shaohua Ge, JiaLu Li, Tao Ning, Ting Deng, Qian Fan, Hongli Li, Wu Sun, Guoguang Ying, Yi Ba Tags: Original Article Source Type: research
Nek2 siRNA therapy using a portal venous port‐catheter system for liver metastasis in pancreatic cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - May 31, 2016 Category: Cancer & Oncology Authors: Toshio Kokuryo, Shigeru Hibino, Kazushi Suzuki, Katsutaka Watanabe, Yukihiro Yokoyama, Masato Nagino, Takeshi Senga, Michinari Hamaguchi Tags: Original Article Source Type: research
Nek2 siRNA therapy using a portal venous port ‐catheter system for liver metastasis in pancreatic cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - June 17, 2016 Category: Cancer & Oncology Authors: Toshio Kokuryo, Shigeru Hibino, Kazushi Suzuki, Katsutaka Watanabe, Yukihiro Yokoyama, Masato Nagino, Takeshi Senga, Michinari Hamaguchi Tags: Original Article Source Type: research
In vivo delivery of siRNA targeting vasohibin‐2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer
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Source: Cancer Science - September 1, 2013 Category: Cancer & Oncology Authors: Takahiro Koyanagi, Yasuhiro Suzuki, Yasushi Saga, Shizuo Machida, Yuji Takei, Hiroyuki Fujiwara, Mitsuaki Suzuki, Yasufumi Sato Tags: Original Article Source Type: research
Suppression of autophagy by CUB domain‐containing protein 1 signaling is essential for anchorage‐independent survival of lung cancer cells
CUB (C1r/C1s, urchin embryonic growth factor, BMP1) domain‐containing protein 1 (CDCP1) has been implicated in promoting metastasis of cancer cells through several mechanisms, including the inhibition of anoikis, which is cell death triggered by the loss of extracellular matrix interactions. However, the mechanism inhibiting cell death regulated by CDCP1 remains elusive. Inhibition of CDCP1 expression using small interfering RNA (siRNA) induced the cell death of suspended cancer cells without cleaving caspase‐3, a marker of apoptosis; cell death was not inhibited by a general caspase inhibitor, suggesting that the loss...
Source: Cancer Science - April 19, 2013 Category: Cancer & Oncology Authors: Takamasa Uekita, Satoko Fujii, Yuri Miyazawa, Akinori Hashiguchi, Hitosi Abe, Michiie Sakamoto, Ryuichi Sakai Tags: Original Article Source Type: research
Expression of Gal‐1 in carcinoma‐associated fibroblasts promotes gastric cancer cell invasion through up‐regulation of integrin β1
In conclusion, our results showed that high expression of Gal‐1 in CAFs might facilitate gastric cancer cell migration and invasion by up‐regulating the integrin β1 expression in gastric cancer.
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Source: Cancer Science - August 1, 2014 Category: Cancer & Oncology Authors: Xu‐Jun He, Hou‐Quan Tao, Zhi‐Ming Hu, Ying‐Yu Ma, Ji Xu, Hui‐Ju Wang, Ying‐Jie Xia, Li Li, Bao‐Ying Fei, Ya‐Qing Li, Jian‐Zhong Chen Tags: Original Article Source Type: research
Expression of galectin‐1 in carcinoma‐associated fibroblasts promotes gastric cancer cell invasion through upregulation of integrin β1
In this study, we cultured gastric cancer CAFs, which showed strong expression of Gal‐1, and established a co‐culture system of CAFs with gastric cancer cells. Specific siRNA and in vitro migration and invasion assays were used to explore the effects of the interaction between Gal‐1 expression of CAFs and gastric cancer cells on cell migration and invasion. We found that the overexpression of Gal‐1 in CAFs enhanced gastric cancer cell migration and invasion, and these stimulatory effects could be blocked by specific siRNA which reduced the Gal‐1 expression level. A set of cancer invasion‐associated genes were t...
Source: Cancer Science - October 23, 2014 Category: Cancer & Oncology Authors: Xu‐Jun He, Hou‐Quan Tao, Zhi‐Ming Hu, Ying‐Yu Ma, Ji Xu, Hui‐Ju Wang, Ying‐Jie Xia, Li Li, Bao‐Ying Fei, Ya‐Qing Li, Jian‐Zhong Chen Tags: Original Article Source Type: research
Cycloamylose‐nanogel drug delivery system‐mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment
RNAi enables potent and specific gene silencing, potentially offering useful means for treatment of cancers. However, safe and efficient drug delivery systems (DDS) that are appropriate for intra‐tumor delivery of siRNA or shRNA have rarely been established, hindering clinical application of RNAi technology to cancer therapy. We have devised hydrogel polymer nanoparticles, or nanogel, and shown its validity as a novel DDS for various molecules. Here we examined the potential of self‐assembled nanogel of cholesterol‐bearing cycloamylose with spermine group (CH‐CA‐Spe) to deliver vascular endothelial growth factor ...
Source: Cancer Science - December 15, 2014 Category: Cancer & Oncology Authors: Hidetaka Fujii, Masaharu Shin‐Ya, Shigeo Takeda, Yoshihide Hashimoto, Sada‐atsu Mukai, Shin‐ichi Sawada, Tetsuya Adachi, Kazunari Akiyoshi, Tsuneharu Miki, Osam Mazda Tags: Original Article Source Type: research
GC7 Sensitizes Bladder Cancer Cells to Doxorubicin by Preventing EMT via Inhibiting eIF5A2 Activation
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Source: Cancer Science - November 1, 2013 Category: Cancer & Oncology Authors: Jinsong Yang, Haogang Yu, Mo Shen, Wei Wei, Lihong Xia, Peng Zhao Tags: Original Article Source Type: research
N1‐guanyl‐1,7‐diaminoheptane sensitizes bladder cancer cells to doxorubicin by preventing epithelial–mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2 activation
Drug resistance greatly reduces the efficacy of doxorubicin‐based chemotherapy in bladder cancer treatment; however, the underlying mechanisms are poorly understood. We aimed to investigate whether N1‐guanyl‐1,7‐diaminoheptane (GC7), which inhibits eukaryotic translation initiation factor 5A2 (eIF5A2) activation, exerts synergistic cytotoxicity with doxorubicin in bladder cancer, and whether eIF5A2 is involved in chemoresistance to doxorubicin‐based bladder cancer treatment. BIU‐87, J82, and UM‐UC‐3 bladder cancer cells were transfected with eIF5A2 siRNA or negative control siRNA before incubation with doxo...
Source: Cancer Science - January 7, 2014 Category: Cancer & Oncology Authors: Jinsong Yang, Haogang Yu, Mo Shen, Wei Wei, Lihong Xia, Peng Zhao Tags: Original Article Source Type: research
Cycloamylose‐Nanogel DDS‐mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment
This article is protected by copyright. All rights reserved.
Source: Cancer Science - September 1, 2014 Category: Cancer & Oncology Authors: Hidetaka Fujii, Masaharu Shin‐Ya, Shigeo Takeda, Yoshihide Hashimoto, Sadaatsu Mukai, Shin‐ichi Sawada, Tetsuya Adachi, Kazunari Akiyoshi, Tsuneharu Miki, Osam Mazda Tags: Original Article Source Type: research
Sall2 up‐regulates p16 expression through a proximal promoter element
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Source: Cancer Science - December 1, 2014 Category: Cancer & Oncology Authors: Zhenghua Wu, Kebin Cheng, Lidan Shi, Zheqi Li, Hema Negi, Guangwei Gao, Suchitra Kamle, Dawei Li Tags: Original Article Source Type: research
BAF57 expression of ovarian cancer cells and drug sensitivity
This article is protected by copyright. All rights reserved.
Source: Cancer Science - January 22, 2015 Category: Cancer & Oncology Authors: Takahiro Yamaguchi, Tomoko Kurita, Kazuto Nishio, Junichi Tsukada, Toru Hachisuga, Yasuo Morimoto, Yoshiko Iwai, Hiroto Izumi Tags: Original Article Source Type: research
