Filtered By:
Source: Cancer Science
This page shows you your search results in order of date. This is page number 5.
Order by Relevance | Date
Total 106 results found since Jan 2013.
FGF‐1/‐3/FGFR4 signaling in cancer‐associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP‐7
Cancer‐associated fibroblasts (CAFs), as the activated fibroblasts in the tumor stroma, are important modifiers of tumour progression. In the present study, we observed that azoxymethane and dextran sodium sulfate treatments induced increasingly severe colorectal mucosal inflammation and the intratumoural accumulation of CAFs. Fibroblast growth factor (FGF)‐1 and FGF‐3 were detected in infiltrating cells, and FGFR4, the specific receptor for FGF‐1 and FGF‐3, was detected in colon cancer tissues. The phosphorylation of FGFR4 enhanced the production of metalloproteinase (MMP)‐7 and mitogen‐activated protein kin...
Source: Cancer Science - September 4, 2015 Category: Cancer & Oncology Authors: Yu‐Pan Bai, Kun Shang, Huan Chen, Fei Ding, Zhen Wang, Chen Liang, Ye Xu, Meng‐Hong Sun, Ying‐Yi LI Tags: Original Article Source Type: research
Significance of P‐cadherin overexpression and possible mechanism of its regulation in intrahepatic cholangiocarcinoma and pancreatic cancer
In this study, we analyzed the expression of P‐cadherin and its clinicopathological and prognostic values in intrahepatic cholangiocarcinoma (ICC) and pancreatic cancer. Furthermore, we investigated the functional role of P‐cadherin in these cancer cells by knockdown and overexpression in vitro and by analyzing the correlation between the P‐cadherin expression and its promoter methylation status. Thirty of 59 ICC cases (51%) and 36 of 73 pancreatic cancer cases (49%) stained positive for P‐cadherin with mainly membranous distribution in tumor cells by immunohistochemistry. P‐cadherin expression was significantly...
Source: Cancer Science - August 18, 2015 Category: Cancer & Oncology Authors: Keita Sakamoto, Katsunori Imai, Takaaki Higashi, Katunobu Taki, Shigeki Nakagawa, Hirohisa Okabe, Hidetoshi Nitta, Hiromitsu Hayashi, Akira Chikamoto, Takatoshi Ishiko, Toru Beppu, Hideo Baba Tags: Original Article Source Type: research
Apurinic/apyrimidinic endonuclease 1 regulates angiogenesis via a transforming growth factor β‐dependent manner in human osteosarcoma
This article is protected by copyright. All rights reserved.
Source: Cancer Science - August 6, 2015 Category: Cancer & Oncology Authors: Xuan Jiang, Jinglu Shan, Nan Dai, Zhaoyang Zhong, Yi Qing, Yuxing Yang, Shiheng Zhang, Chongyi Li, Jiangdong Sui, Tao Ren, Mengxia Li, Dong Wang Tags: Original Article Source Type: research
CRKL oncogene is downregulated by p53 through miR‐200s
Tumor suppressive miRNAs that target oncogenes are frequently downregulated in cancers, and this downregulation leads to oncogene pathway activation. Thus, tumor suppressive miRNAs and their target oncogenes have been proposed as useful targets in cancer treatment. miR‐200 family downregulation has been reported in cancer progression and metastasis. The miR‐200 family consists of two gene clusters, miR‐200b/200a/429 and miR‐200c/141, which are located on human chromosomes 1 and 12, respectively. Here, we identified that p53 response elements are located around both clusters of the miR‐200 family and confirmed tha...
Source: Cancer Science - July 14, 2015 Category: Cancer & Oncology Authors: Miyuki Tamura, Yasushi Sasaki, Kenta Kobashi, Kousuke Takeda, Takafumi Nakagaki, Masashi Idogawa, Takashi Tokino Tags: Original Article Source Type: research
FGF‐1/‐3/FGFR4 signalling in cancer‐associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP‐7
This article is protected by copyright. All rights reserved.
Source: Cancer Science - July 1, 2015 Category: Cancer & Oncology Authors: Yu‐Pan Bai, Kun Shang, Huan Chen, Fei Ding, Zhen Wang, Chen Liang, Ye Xu, Meng‐Hong Sun, Ying‐Yi Li Tags: Original Article Source Type: research
Histone deacetylase 3 expression correlates with vasculogenic mimicry through the phosphoinositide3‐kinase / ERK–MMP–laminin5γ2 signaling pathway
In this study, we subjected glioma specimens to immunohistochemical and histochemical double‐staining methods and found that VM and HDAC3 expression were related to the pathological grade of gliomas. The presence of VM correlated with HDAC3 expression in glioma tissues. The formation of tubular structures, as determined by the tube formation assay to evaluate VM, was impaired in U87MG cells when transfected by siRNA or treated with an HDAC3 inhibitor. Importantly, the expression of VM‐related molecules such as MMP‐2/14 and laminin5γ2 was also affected when HDAC3 expression was altered. Furthermore, U87MG cells were ...
Source: Cancer Science - June 18, 2015 Category: Cancer & Oncology Authors: Xiao Liu, Ji‐Hui Wang, Shun Li, Lin‐Lin Li, Min Huang, Yong‐Hong Zhang, Yang Liu, Yuan‐Tao Yang, Rui Ding, Yi‐Quan Ke Tags: Original Article Source Type: research
Significance of P‐cadherin overexpression and possible mechanism of its regulation in ICC and pancreatic cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - June 1, 2015 Category: Cancer & Oncology Authors: Keita Sakamoto, Katsunori Imai, Takaaki Higashi, Katunobu Taki, Shigeki Nakagawa, Hirohisa Okabe, Hidetoshi Nitta, Hiromitsu Hayashi, Akira Chikamoto, Takatoshi Ishiko, Toru Beppu, Hideo Baba Tags: Original Article Source Type: research
The CRKL oncogene is downregulated by p53 through miR‐200s
This article is protected by copyright. All rights reserved.
Source: Cancer Science - June 1, 2015 Category: Cancer & Oncology Authors: Miyuki Tamura, Yasushi Sasaki, Kenta Kobashi, Kousuke Takeda, Takafumi Nakagaki, Masashi Idogawa, Takashi Tokino Tags: Original Article Source Type: research
HDAC3 expression correlates with vasculogenic mimicry via the PI3K/ERK‐MMPs‐Ln5γ2 signaling pathway
This article is protected by copyright. All rights reserved.
Source: Cancer Science - May 2, 2015 Category: Cancer & Oncology Authors: Xiao Liu, Ji‐Hui Wang, Shun Li, Lin‐Lin Li, Min Huang, Yong‐Hong Zhang, Yang Liu, Yuan‐Tao Yang, Rui Ding, Yi‐Quan Ke Tags: Original Article Source Type: research
BRCA/Fanconi anemia pathway implicates chemoresistance to gemcitabine in biliary tract cancer
The BRCA/Fanconi anemia (FA) pathway plays a key role in the repair of DNA double strand breaks. We focused on this pathway to clarify chemoresistance mechanisms in biliary tract cancer (BTC). We also investigated changes in the CD24+/44+ population that may be involved in chemoresistance, as this population likely includes cancer stem cells. We used three BTC cell lines to establish gemcitabine (GEM)‐resistant (GR) cells and evaluated the expression of BRCA/FA pathway components, chemoresistance, and the effect of BRCA/FA pathway inhibition on the CD24+/44+ population. FANCD2 and CD24 expression were evaluated in 108 re...
Source: Cancer Science - April 22, 2015 Category: Cancer & Oncology Authors: Shinsuke Nakashima, Shogo Kobayashi, Hiroaki Nagano, Akira Tomokuni, Yoshito Tomimaru, Tadafumi Asaoka, Naoki Hama, Hiroshi Wada, Koichi Kawamoto, Shigeru Marubashi, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori Tags: Original Article Source Type: research
Activation of AMP‐activated protein kinase by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib
In this study, we investigated the effects of combined treatment using sorafenib and retinoids including all‐trans retinoic acid (ATRA), NIK‐333, and Am80 on HCC cells. Cell viability assays in six HCC cell lines, HepG2, PLC/PRF/5, HuH6, HLE, HLF, and Hep3B, revealed that 5 and 10 μM ATRA, concentrations that do not exert cytotoxic effects, enhanced the cytotoxicity of sorafenib, being much more effective than NIK‐333 and Am80. We found that ATRA induced AMP‐activated protein kinase activation, which was followed by reduced intracellular ATP level. Gene expression analysis revealed that ATRA decreased the express...
Source: Cancer Science - March 9, 2015 Category: Cancer & Oncology Authors: Naoki Ishijima, Keita Kanki, Hiroki Shimizu, Goshi Shiota Tags: Original Article Source Type: research
BRCA/Fanconi Anemia Pathway Implicates Chemo‐resistance to Gemcitabine in Biliary Tract Cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - March 3, 2015 Category: Cancer & Oncology Authors: Shinsuke Nakashima, Shogo Kobayashi, Hiroaki Nagano, Akira Tomokuni, Yoshito Tomimaru, Tadafumi Asaoka, Naoki Hama, Hiroshi Wada, Koichi Kawamoto, Shigeru Marubashi, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori Tags: Original Article Source Type: research
Sal‐like protein 2 upregulates p16 expression through a proximal promoter element
Sal‐like protein 2 (Sall2), a homeotic transcription factor, is a putative tumor suppressor. We have previously shown that Sall2 activates the transcription of tumor suppressor gene p21 and suppresses tumorigenesis through cell cycle inhibition and induction of apoptosis. To investigate additional Sall2‐regulated downstream genes, we analyzed the differences in mRNA expression profiles with and without exogenously expressed Sall2. We identified 1616 Sall2‐responsive genes through gene expression arrays. Promoter‐reporter assays of p16INK4A and several other tumor‐related genes indicated that the Sall2 regulation ...
Source: Cancer Science - March 3, 2015 Category: Cancer & Oncology Authors: Zhenghua Wu, Kebin Cheng, Lidan Shi, Zheqi Li, Hema Negi, Guangwei Gao, Suchitra Kamle, Dawei Li Tags: Original Article Source Type: research
Expression of BAF57 in ovarian cancer cells and drug sensitivity
In this study, we investigated BAF57 expression in ovarian cancer cell lines and their sensitivities to cisplatin, doxorubicin, paclitaxel, and 5‐fluorouracil. BAF57 expression was strongly correlated with sensitivities to cisplatin, doxorubicin, and 5‐fluorouracil in 10 ovarian cancer cell lines. Paclitaxel sensitivity was also correlated with BAF57 expression, but without significance. In A2780 ovarian cancer cells, knockdown of BAF57 using specific siRNA increased cell cycle arrest at G1 phase and the sensitivities to these anticancer agents. cDNA microarray analysis of A2780 cells transfected with BAF57 siRNA showe...
Source: Cancer Science - February 25, 2015 Category: Cancer & Oncology Authors: Takahiro Yamaguchi, Tomoko Kurita, Kazuto Nishio, Junichi Tsukada, Toru Hachisuga, Yasuo Morimoto, Yoshiko Iwai, Hiroto Izumi Tags: Original Article Source Type: research
AMPK activation by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib
This article is protected by copyright. All rights reserved.
Source: Cancer Science - February 12, 2015 Category: Cancer & Oncology Authors: Naoki Ishijima, Keita Kanki, Hiroki Shimizu, Goshi Shiota Tags: Original Article Source Type: research
