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Source: Cancer Science
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Total 106 results found since Jan 2013.
N1‐guanyl‐1,7‐diaminoheptane sensitizes bladder cancer cells to doxorubicin by preventing epithelial–mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2 activation
Drug resistance greatly reduces the efficacy of doxorubicin‐based chemotherapy in bladder cancer treatment; however, the underlying mechanisms are poorly understood. We aimed to investigate whether N1‐guanyl‐1,7‐diaminoheptane (GC7), which inhibits eukaryotic translation initiation factor 5A2 (eIF5A2) activation, exerts synergistic cytotoxicity with doxorubicin in bladder cancer, and whether eIF5A2 is involved in chemoresistance to doxorubicin‐based bladder cancer treatment. BIU‐87, J82, and UM‐UC‐3 bladder cancer cells were transfected with eIF5A2 siRNA or negative control siRNA before incubation with doxo...
Source: Cancer Science - January 7, 2014 Category: Cancer & Oncology Authors: Jinsong Yang, Haogang Yu, Mo Shen, Wei Wei, Lihong Xia, Peng Zhao Tags: Original Article Source Type: research
GC7 Sensitizes Bladder Cancer Cells to Doxorubicin by Preventing EMT via Inhibiting eIF5A2 Activation
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Source: Cancer Science - November 1, 2013 Category: Cancer & Oncology Authors: Jinsong Yang, Haogang Yu, Mo Shen, Wei Wei, Lihong Xia, Peng Zhao Tags: Original Article Source Type: research
Dihydropyrimidinase‐like protein 3 expression is negatively regulated by MYCN and associated with clinical outcome in neuroblastoma
Dihydropyrimidinase‐like proteins (DPYSLs) are a family of proteins developmentally regulated during maturation of the nervous system. Recently, members of the DPYSL family have been reported to be involved in cancer with low expression of DPYSL1 correlating with poor clinical outcomes in non‐small cell lung cancer and functioning as a metastasis suppressor. Neuroblastoma (NB) is a tumor derived from precursor cells of the sympathetic nervous system and is the most common solid tumor in childhood. So far the biological functions of DPYSLs in NB remain elusive. Studying the potential roles of DPYSLs in NB may give us ne...
Source: Cancer Science - October 20, 2013 Category: Cancer & Oncology Authors: Fei Tan, Reema Wahdan‐Alaswad, Shuang Yan, Carol J. Thiele, Zhijie Li Tags: Original Article Source Type: research
Heregulin Induces Resistance to Lapatinib‐mediated Growth Inhibition of HER2‐Amplified Cancer Cells
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Source: Cancer Science - September 24, 2013 Category: Cancer & Oncology Authors: Yuji Sato, Masakazu Yashiro, Nobuyuki Takakura Tags: Original Article Source Type: research
Forkhead box protein C2 contributes to invasion and metastasis of extrahepatic cholangiocarcinoma, resulting in a poor prognosis
Extrahepatic cholangiocarcinoma (EHCC) is a cancer with a poor prognosis, and the postoperative survival of patients depends on the existence of invasion and metastasis. The epithelial‐to‐mesenchymal transition (EMT) is an important step in EHCC invasion and metastasis. Forkhead box protein C2 (FOXC2) is a transcription factor that has been reported to induce the EMT. Therefore we examined the correlation between FOXC2 expression and clinical pathological factors, and analysed the function of FOXC2. The expression of FOXC2 in 77 EHCC cases was investigated by immunohistochemical staining, and the relationship between F...
Source: Cancer Science - September 15, 2013 Category: Cancer & Oncology Authors: Akira Watanabe, Hideki Suzuki, Takehiko Yokobori, Bolag Altan, Norio Kubo, Kenichiro Araki, Satoshi Wada, Yasushi Mochida, Shigeru Sasaki, Kenji Kashiwabara, Yasuo Hosouchi, Hiroyuki Kuwano Tags: Original Article Source Type: research
DPYSL3 expression is negatively regulated by MYCN and associated with clinical outcome in neuroblastoma
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Source: Cancer Science - September 6, 2013 Category: Cancer & Oncology Authors: Fei Tan, Reema Wahdan‐Alaswad, Shuang Yan, Carol J. Thiele, Zhijie Li Tags: Original Article Source Type: research
Peneciraistin C induces caspase‐independent autophagic cell death through mitochondrial‐derived reactive oxygen species production in lung cancer cells
Peneciraistin C (Pe‐C) is a novel spiroketal compound isolated from the saline soil derived fungus Penicillium raistrickii. Our previous study showed that Pe‐C exerted a potent cytotoxic effect on many kinds of cancer cell lines, especially on human lung cancer A549 cells. Here, we report the anticancer mechanisms of Pe‐C in a variety of lung cancer cells. The results showed that Pe‐C induced caspase‐independent autophagic cell death and elevated mitochondrial‐derived reactive oxygen species levels. Interestingly, if autophagy was blocked by 3‐methyladenine or Atg5 siRNA, Pe‐C triggered a shift from autopha...
Source: Cancer Science - September 2, 2013 Category: Cancer & Oncology Authors: Xiaohong Pan, Desheng Liu, Juan Wang, Xiuli Zhang, Miaomiao Yan, Dehai Zhang, Jinjin Zhang, Weizhong Liu Tags: Original Article Source Type: research
In vivo delivery of siRNA targeting vasohibin‐2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer
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Source: Cancer Science - September 1, 2013 Category: Cancer & Oncology Authors: Takahiro Koyanagi, Yasuhiro Suzuki, Yasushi Saga, Shizuo Machida, Yuji Takei, Hiroyuki Fujiwara, Mitsuaki Suzuki, Yasufumi Sato Tags: Original Article Source Type: research
Inhibition of Wnt/β‐catenin signaling downregulates P‐glycoprotein and reverses multi‐drug resistance of cholangiocarcinoma
In this study, we established a human MDR CCA cell line QBC939/5‐FU. Compared with QBC939 cells, a rounder shape, a higher nuclear–cytoplasmic ratio, a shorter cell cycle, faster growth and resistance to chemotherapeutics are major characteristics of QBC939/5‐FU cells. P‐glycoprotein (P‐gp) and β‐catenin were upregulated in QBC939/5‐FU cells. Furthermore, the drug susceptibility of QBC939 cells to common chemotherapeutics was significantly decreased after Wnt3a treatment, whereas inhibition of Wnt/β‐catenin pathway by β‐catenin siRNA reversed the MDR of QBC939/5‐FU cells to chemotherapeutics. Molecul...
Source: Cancer Science - August 6, 2013 Category: Cancer & Oncology Authors: Dong‐Yan Shen, Wei Zhang, Xin Zeng, Chang‐Qin Liu Tags: Original Article Source Type: research
FOXC2 contributes to invasion and metastasis of extrahepatic cholangiocarcinoma, resulting in a poor prognosis
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Source: Cancer Science - August 1, 2013 Category: Cancer & Oncology Authors: Akira Watanabe, Hideki Suzuki, Takehiko Yokobori, Bolag Altan, Norio Kubo, Kenichiro Araki, Satoshi Wada, Yasushi Mochida, Shigeru Sasaki, Kenji Kashiwabara, Yasuo Hosouchi, Hiroyuki Kuwano Tags: Original Article Source Type: research
Peneciraistin C induces caspase‐independent autophagic cell death through mitochondrial‐derived ROS production in lung cancer cells
This article is protected by copyright. All rights reserved.
Source: Cancer Science - August 1, 2013 Category: Cancer & Oncology Authors: Xiaohong Pan, Desheng Liu, Juan Wang, Xiuli Zhang, Miaomiao Yan, Dehai Zhang, Jinjin Zhang, Weizhong Liu Tags: Original Article Source Type: research
Inhibition of Wnt/β‐catenin signaling down‐regulates P‐glycoprotein and reverses multi‐drug resistance of cholangiocarcinoma
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Source: Cancer Science - July 3, 2013 Category: Cancer & Oncology Authors: Dong‐Yan Shen, Wei Zhang, Xin Zeng, Chang‐Qin Liu Tags: Original Article Source Type: research
Suppression of autophagy by CUB domain‐containing protein 1 signaling is essential for anchorage‐independent survival of lung cancer cells
CUB (C1r/C1s, urchin embryonic growth factor, BMP1) domain‐containing protein 1 (CDCP1) has been implicated in promoting metastasis of cancer cells through several mechanisms, including the inhibition of anoikis, which is cell death triggered by the loss of extracellular matrix interactions. However, the mechanism inhibiting cell death regulated by CDCP1 remains elusive. Inhibition of CDCP1 expression using small interfering RNA (siRNA) induced the cell death of suspended cancer cells without cleaving caspase‐3, a marker of apoptosis; cell death was not inhibited by a general caspase inhibitor, suggesting that the loss...
Source: Cancer Science - April 19, 2013 Category: Cancer & Oncology Authors: Takamasa Uekita, Satoko Fujii, Yuri Miyazawa, Akinori Hashiguchi, Hitosi Abe, Michiie Sakamoto, Ryuichi Sakai Tags: Original Article Source Type: research
Identification of a lung adenocarcinoma cell line with CCDC6‐RET fusion gene and the effect of RET inhibitors in vitro and in vivo
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Source: Cancer Science - April 11, 2013 Category: Cancer & Oncology Authors: Makito Suzuki, Hideki Makinoshima, Shingo Matsumoto, Ayako Suzuki, Sachiyo Mimaki, Koutatsu Matsushima, Kiyotaka Yoh, Koichi Goto, Yutaka Suzuki, Genichiro Ishii, Atsushi Ochiai, Koji Tsuta, Tatsuhiro Shibata, Takashi Kohno, Hiroyasu Esumi, Katsuya Tsuchi Tags: Original Article Source Type: research
Mesenchymal stem cells regulate epithelial–mesenchymal transition and tumor progression of pancreatic cancer cells
Cancer‐associated fibroblasts contribute to cancer progression that is caused by epithelial–mesenchymal transition (EMT). Recently, mesenchymal stem cells (MSCs) were found to be the major candidate involved in the development of tumor‐promoting cancer stroma. Here we report that α‐smooth muscle actin‐positive myofibroblast‐like cells originating from MSCs contribute to inducing EMT in side population cells of pancreatic cancer. More importantly, MSC‐derived myofibroblasts function to maintain tumor‐initiating stem cell‐like characteristics, including augmenting expression levels of various stemness‐as...
Source: Cancer Science - January 11, 2013 Category: Cancer & Oncology Authors: Ayano Kabashima‐Niibe, Hajime Higuchi, Hiromasa Takaishi, Yohei Masugi, Yumi Matsuzaki, Yo Mabuchi, Shinsuke Funakoshi, Masayuki Adachi, Yasuo Hamamoto, Shigeyuki Kawachi, Koichi Aiura, Yuko Kitagawa, Michiie Sakamoto, Toshifumi Hibi Tags: Original Article Source Type: research
