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Source: Cancer Science
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Total 106 results found since Jan 2013.
Nek2 siRNA therapy using a portal venous port –catheter system for liver metastasis in pancreatic cancer
In this study, the overexpression of Nek2 was identified in pancreatic cancer cell lines. Nek2 siRNA inhibited tumor growth in a subcutaneous xenograft mouse model of pancreatic cancer, prolonged the survival time in an intraperitoneal xenograft mouse model and efficiently prevented the progression of liver metastasis using a portal venous port–catheter system. Taken together, Nek2 is an effective therapeutic target in pancreatic cancer. An adequate delivery system is considered important in treating advanced pancreatic cancer, such as peritoneal dissemination and liver metastasis. Further investigations are required on ...
Source: Cancer Science - August 11, 2016 Category: Cancer & Oncology Authors: Toshio Kokuryo, Shigeru Hibino, Kazushi Suzuki, Katsutaka Watanabe, Yukihiro Yokoyama, Masato Nagino, Takeshi Senga, Michinari Hamaguchi Tags: Original Article Source Type: research
Role of galectin ‐1 in urinary bladder urothelial carcinoma cell invasion through c‐Jun N‐terminal protein kinase pathway
This article is protected by copyright. All rights reserved.
Source: Cancer Science - June 30, 2016 Category: Cancer & Oncology Authors: Kun ‐Hung Shen, Chien‐Feng Li, Lan‐Hsiang Chien, Cheng‐Hao Huang, Chia‐Cheng Su, Alex C Liao, Ting‐Feng Wu Tags: Original Article Source Type: research
Nek2 siRNA therapy using a portal venous port ‐catheter system for liver metastasis in pancreatic cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - June 17, 2016 Category: Cancer & Oncology Authors: Toshio Kokuryo, Shigeru Hibino, Kazushi Suzuki, Katsutaka Watanabe, Yukihiro Yokoyama, Masato Nagino, Takeshi Senga, Michinari Hamaguchi Tags: Original Article Source Type: research
Nek2 siRNA therapy using a portal venous port‐catheter system for liver metastasis in pancreatic cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - May 31, 2016 Category: Cancer & Oncology Authors: Toshio Kokuryo, Shigeru Hibino, Kazushi Suzuki, Katsutaka Watanabe, Yukihiro Yokoyama, Masato Nagino, Takeshi Senga, Michinari Hamaguchi Tags: Original Article Source Type: research
SERPINI1 regulates epithelial–mesenchymal transition in an orthotopic implantation model of colorectal cancer
An increasingly accepted concept is that the progression of colorectal cancer is accompanied by epithelial–mesenchymal transition (EMT). In our study, in order to characterize the properties of EMT in 16 colorectal cancer cell lines, the cells were first orthotopically implanted into nude mice, and the tumors in vivo, as well as cells cultured in vitro, were immunostained for EMT markers. The immunostaining revealed that seven of the cells had an epithelial phenotype with a high expression of E‐cadherin, whereas other cells showed opposite patterns, such as a high expression of vimentin (CX‐1, COLO205, CloneA, HCT116...
Source: Cancer Science - March 27, 2016 Category: Cancer & Oncology Authors: Yasufumi Matsuda, Koh Miura, Junko Yamane, Hiroshi Shima, Wataru Fujibuchi, Kazuyuki Ishida, Fumiyoshi Fujishima, Shinobu Ohnuma, Hiroyuki Sasaki, Munenori Nagao, Naoki Tanaka, Kennichi Satoh, Takeshi Naitoh, Michiaki Unno Tags: Original Article Source Type: research
SERPINI1 regulates the epithelial‐mesenchymal transition in an orthotopic implantation model of colorectal cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - February 19, 2016 Category: Cancer & Oncology Authors: Yasufumi Matsuda, Koh Miura, Junko Yamane, Hiroshi Shima, Wataru Fujibuchi, Kazuyuki Ishida, Fumiyoshi Fujishima, Shinobu Ohnuma, Hiroyuki Sasaki, Munenori Nagao, Naoki Tanaka, Kennichi Satoh, Takeshi Naitoh, Michiaki Unno Tags: Original Article Source Type: research
Timosaponin AIII inhibits melanoma cell migration by suppressing COX‐2 and in vivo tumor metastasis
We examined the effects of timosaponin AIII, a compound isolated from Anemarrhena asphodeloides Bunge, on melanoma cancer cell migration and the molecular mechanisms underlying these effects using B16‐F10 and WM‐115 melanoma cells lines. Overexpression of COX‐2, its metabolite prostaglandin E2 (PGE2), and PGE2 receptors (EP2 and EP4) promoted cell migration in vitro. Exposure to timosaponin AIII resulted in concentration‐dependent inhibition of cell migration, which was associated with reduced levels of COX‐2, PGE2, and PGE2 receptors. Transient transfection of COX‐2 siRNA also inhibited cell migration. Exposur...
Source: Cancer Science - January 22, 2016 Category: Cancer & Oncology Authors: Ki Mo Kim, A‐Rang Im, Seung Hyung Kim, Jin Won Hyun, Sungwook Chae Tags: Original Article Source Type: research
Expression of Forkhead box M1 in soft tissue leiomyosarcoma: Clinicopathologic and in vitro study using a newly established cell line
In conclusion, FOXM1 has potential to be a therapeutic target for LMS.
Fork head box M1 inhibition is a potential treatment option for soft tissue leiomyosarcoma.
Source: Cancer Science - January 12, 2016 Category: Cancer & Oncology Authors: Akira Maekawa, Kenichi Kohashi, Nokitaka Setsu, Masaaki Kuda, Kunio Iura, Takeaki Ishii, Tomoya Matsunobu, Tetsuya Nakatsura, Yukihide Iwamoto, Yoshinao Oda Tags: Original Article Source Type: research
Specific transport of 3‐fluoro‐l‐α‐methyl‐tyrosine by LAT1 explains its specificity to malignant tumors in imaging
This study has established FAMT as a LAT1‐specific molecular probe to monitor the expression of a potential tumor biomarker LAT1.
This article is protected by copyright. All rights reserved.
Source: Cancer Science - January 7, 2016 Category: Cancer & Oncology Authors: Ling Wei, Hideyuki Tominaga, Ryuichi Ohgaki, Pattama Wiriyasermkul, Kohei Hagiwara, Suguru Okuda, Kyoichi Kaira, Noboru Oriuchi, Shushi Nagamori, Yoshikatsu Kanai Tags: Original Article Source Type: research
Wnt5a‐Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16‐CXCR6 axis
This article is protected by copyright. All rights reserved.
Source: Cancer Science - December 1, 2015 Category: Cancer & Oncology Authors: Gosuke Takiguchi, Michiru Nishita, Kana Kurita, Yoshihiro Kakeji, Yasuhiro Minami Tags: Original Article Source Type: research
Timosaponin AIII inhibits melanoma cell migration by suppressing cyclooxygenase‐2 and in vivo tumor metastasis
This article is protected by copyright. All rights reserved.
Source: Cancer Science - November 1, 2015 Category: Cancer & Oncology Authors: Ki Mo Kim, A‐Rang Im, Seung Hyung Kim, Jin Won Hyun, Sungwook Chae Tags: Original Article Source Type: research
Expression of Forkhead Box M1 in soft tissue leiomyosarcoma: Clinicopathological and in vitro study using a newly established cell line
In conclusion, FOXM1 have a potential to be a therapeutic target for LMS.
This article is protected by copyright. All rights reserved.
Source: Cancer Science - November 1, 2015 Category: Cancer & Oncology Authors: Akira Maekawa, Kenichi Kohashi, Setsu Nokitaka, Masaaki Kuda, Kunio Iura, Takeaki Ishii, Tomoya Matsunobu, Tetsuya Nakatsura, Yukihide Iwamoto, Yoshinao Oda Tags: Original Article Source Type: research
Matrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis
In this study, we found that MMP13 was overexpressed in NPC cells and exosomes purified from conditioned medium (CM) as well as NPC patients’ plasma. Transwell analysis revealed that MMP13‐containing exosomes facilitated the metastasis of NPC cells. Furthermore, siRNA inhibited the effect of MMP13‐containing exosomes on tumor cells metastasis as well as angiogenesis. The current findings provided novel insight into the vital role of MMP13‐containing exosomes in NPC progression which might offer unique insights for potential therapeutic strategies for NPC progressions.
This work proved that MMP13‐containning exos...
Source: Cancer Science - October 13, 2015 Category: Cancer & Oncology Authors: Yiwen You, Ying Shan, Jing Chen, Huijun Yue, Bo You, Si Shi, Xingyu Li, Xiaolei Cao Tags: Original Article Source Type: research
Apurinic/apyrimidinic endonuclease 1 regulates angiogenesis in a transforming growth factor β‐dependent manner in human osteosarcoma
Angiogenesis plays an important role in tumor growth and metastasis and has been reported to be inversely correlated with overall survival of osteosarcoma patients. It has been shown that apurinic/apyrimidinic endonuclease 1 (APE1), a dually functional protein possessing both base excision repair and redox activities, is involved in tumor angiogenesis, although these mechanisms are not fully understood. Our previous study showed that the expression of transforming growth factor β (TGFβ) was significantly reduced in APE1‐deficient osteosarcoma cells. Transforming growth factor β promotes cancer metastasis through vario...
Source: Cancer Science - September 25, 2015 Category: Cancer & Oncology Authors: Xuan Jiang, Jinlu Shan, Nan Dai, Zhaoyang Zhong, Yi Qing, Yuxing Yang, Shiheng Zhang, Chongyi Li, Jiangdong Sui, Tao Ren, Mengxia Li, Dong Wang Tags: Original Article Source Type: research
MMP13‐containing exosomes promote nasopharyngeal carcinoma metastasis
This article is protected by copyright. All rights reserved.
Source: Cancer Science - September 12, 2015 Category: Cancer & Oncology Authors: You Yiwen, Ying Shan, Jing Chen, Huijun Yue, You Bo, Si Shi, Xingyu Li, Xiaolei Cao Tags: Original Article Source Type: research
