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Source: Cancer Science
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Total 106 results found since Jan 2013.
Crosstalk between ovarian cancer cells and macrophages via periostin promotes macrophage recruitment
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Source: Cancer Science - March 1, 2018 Category: Cancer & Oncology Authors: Meng Tang, Bingji Liu, Xiaocui Bu, Peng Zhao Tags: Original Article Source Type: research
MicroRNA ‐155 promotes gastric cancer growth and invasion by negatively regulating transforming growth factor‐β receptor 2
This study demonstrated for the first time that miR‐155 can target TGFβR2 to promote GC growth and invasion, and we identified the miR‐155 — TGF?R2 axis in GC.
Source: Cancer Science - February 14, 2018 Category: Cancer & Oncology Authors: Yajing Qu, Haiyang Zhang, Wu Sun, Yueting Han, Shuang Li, Yanjun Qu, Guoguang Ying, Yi Ba Tags: ORIGINAL ARTICLE Source Type: research
Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor siRNA
Exosomes derived from cells have been found to mediate signal transduction between cells and to act as efficient carriers to deliver drugs and small RNA. Hepatocyte growth factor (HGF) is known to promote the growth of both cancer cells and vascular cells, and the HGF‐cMET pathway is a potential clinical target. Here, we characterized the inhibitory effect of HGF siRNA on tumor growth and angiogenesis in gastric cancer. In addition, we showed that HGF siRNA packed in exosomes can be transported into cancer cells, where it dramatically downregulates HGF expression. A cell co‐culture model was used to show that exosomes ...
Source: Cancer Science - February 11, 2018 Category: Cancer & Oncology Authors: Haiyang Zhang, Yi Wang, Ming Bai, Junyi Wang, Kegan Zhu, Rui Liu, Shaohua Ge, JiaLu Li, Tao Ning, Ting Deng, Qian Fan, Hongli Li, Wu Sun, Guoguang Ying, Yi Ba Tags: ORIGINAL ARTICLE Source Type: research
Exosomes Serve as Nano ‐particles to Suppress Tumor Growth and Angiogenesis in Gastric Cancer by Delivering HGF siRNA
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Source: Cancer Science - December 29, 2017 Category: Cancer & Oncology Authors: Haiyang Zhang, Yi Wang, Ming Bai, Junyi Wang, Kegan Zhu, Rui Liu, Shaohua Ge, JiaLu Li, Tao Ning, Ting Deng, Qian Fan, Hongli Li, Wu Sun, Guoguang Ying, Yi Ba Tags: Original Article Source Type: research
MiR ‐155 promotes gastric cancer growth and invasion by negatively regulating Transforming Growth Factor Beta Receptor 2
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Source: Cancer Science - December 16, 2017 Category: Cancer & Oncology Authors: Yajing Qu, Haiyang Zhang, Wu Sun, Yueting Han, Shuang Li, Yanjun Qu, Guoguang Ying, Yi Ba Tags: Original Article Source Type: research
Testicular orphan receptor 4 promotes tumor progression and implies poor survival through AKT3 regulation in seminoma
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Source: Cancer Science - November 1, 2017 Category: Cancer & Oncology Authors: Yuanlei Chen, Jieyang Lu, Liqun Xia, Dingwei Xue, Xiaoming Yu, Danyang Shen, Liwei Xu, Gonghui Li Tags: Original Article Source Type: research
Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53
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Source: Cancer Science - October 1, 2017 Category: Cancer & Oncology Authors: Ryota Koyama, Miyuki Tamura, Takafumi Nakagaki, Tomoko Ohashi, Masashi Idogawa, Hiromu Suzuki, Takashi Tokino, Yasushi Sasaki Tags: Original Article Source Type: research
Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for Adult T ‐cell Leukemia
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Source: Cancer Science - October 1, 2017 Category: Cancer & Oncology Authors: Takahito Kawata, Kohei Tada, Masayuki Kobayashi, Takashi Sakamoto, Yoko Takiuchi, Fumie Iwai, Maki Sakurada, Masakatsu Hishizawa, Kotaro Shirakawa, Keisuke Shindo, Hironori Sato, Akifumi Takaori ‐Kondo Tags: Original Article Source Type: research
Lipocalin 2 negatively regulates cell proliferation and epithelial to mesenchymal transition through changing metabolic gene expression in colorectal cancer
Lipocalin 2 (LCN2), a member of the lipocalin superfamily, plays an important role in oncogenesis and progression in various types of cancer. However, the expression pattern and functional role of LCN2 in colorectal cancer (CRC) is still poorly understood. The purpose of the present study was to investigate whether LCN2 is associated with proliferation and the epithelial–mesenchymal transition (EMT) in CRC and to elucidate the underlying signaling pathways. LCN2 was preferentially expressed in CRC cells compared to normal tissues. However, LCN2 expression was significantly lower in metastatic or advanced‐stage CRC than...
Source: Cancer Science - September 22, 2017 Category: Cancer & Oncology Authors: Se ‐Lim Kim, Soo Teik Lee, In Suk Min, Young Ran Park, Ju Hyung Lee, Dae‐Ghon Kim, Sang‐Wook Kim Tags: Original Article Source Type: research
Lipocalin 2 negatively regulates cell proliferation and EMT through changing metabolic gene expression in colorectal cancer
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Source: Cancer Science - August 31, 2017 Category: Cancer & Oncology Authors: Se ‐Lim Kim, Soo Teik Lee, In Suk Min, Young Ran Park, Ju Hyung Lee, Dae‐Ghon Kim, Sang‐Wook Kim Tags: Original Article Source Type: research
Downregulation of ULK1 by microRNA ‐372 inhibits the survival of human pancreatic adenocarcinoma cells
Dysregulation of microRNA (miRNA) expression in various cancers and their role in cancer progression is well documented. The purpose of this study was to investigate the biological role of miR‐372 in human pancreatic adenocarcinoma (HPAC). We collected 20 pairs of HPAC tissues and adjacent non‐cancerous tissues to detect miR‐372 expression levels. We transfected BXPC‐3 and PANC‐1 cells with miR‐372 inhibitor/mimics to study their effect on cell proliferation, apoptosis, invasion, migration and autophagy. In addition, miR‐372 mimics and a tumor protein UNC51‐like kinase 1 (ULK1) siRNA were co‐transfected i...
Source: Cancer Science - August 10, 2017 Category: Cancer & Oncology Authors: Hongxi Chen, Zhipeng Zhang, Yebin Lu, Kun Song, Xiwu Liu, Fada Xia, Weijia Sun Tags: ORIGINAL ARTICLE Source Type: research
Survivin: a novel marker and potential therapeutic target for human angiosarcoma
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Source: Cancer Science - August 1, 2017 Category: Cancer & Oncology Authors: Masayuki Tsuneki, Takao Kinjo, Taisuke Mori, Akihiko Yoshida, Kayo Kuyama, Aoi Ohira, Takuya Miyagi, Kenzo Takahashi, Akira Kawai, Hirokazu Chuman, Naoya Yamazaki, Mikio Masuzawa, Hirofumi Arakawa Tags: Original Article Source Type: research
Down ‐regulation of ULK1 by microRNA‐372 inhibits the survival of human pancreatic adenocarcinoma cells
This article is protected by copyright. All rights reserved.
Source: Cancer Science - July 5, 2017 Category: Cancer & Oncology Authors: Hongxi Chen, Zhipeng Zhang, Yebin Lu, Kun Song, Xiwu Liu, Fada Xia, Weijia Sun Tags: Original Article Source Type: research
Suberoylanilide hydroxamic acid sensitizes neuroblastoma to paclitaxel by inhibiting thioredoxin ‐related protein 14‐mediated autophagy
This study explored the regulatory mechanism of paclitaxel‐associated autophagy and potential solutions to paclitaxel resistance in neuroblastoma. The formation of autophagic vesicles was detected by scanning transmission electron microscopy and flow cytometry. The autophagy‐associated proteins were assessed by western blot. Autophagy was induced and the autophagy‐associated proteins LC3‐I, LC3‐II, Beclin 1, and thioredoxin‐related protein 14 (TRP14), were found to be upregulated in neuroblastoma cells that were exposed to paclitaxel. The inhibition of Beclin 1 or TRP14 by siRNA increased the sensitivity of the...
Source: Cancer Science - June 19, 2017 Category: Cancer & Oncology Authors: Zijun Zhen, Kaibin Yang, Litong Ye, Zhiyao You, Rirong Chen, Ying Liu, Youjian He Tags: Original Article Source Type: research
