Metformin inhibits estrogen ‐dependent endometrial cancer cell growth by activating the AMPK–FOXO1 signal pathway

This study provide a novel mechanism of anti‐neoplastic effect for metformin through the regulation of FOXO1, and suggest that AMPK‐FOXO1 pathway may be a therapeutic target to the development of new anti‐neoplastic drugs.

Source: Cancer Science - November 24, 2016 Category: Cancer & Oncology Authors: Jingfang Zou, Liangli Hong, Chaohuan Luo, Zhi Li, Yuzhang Zhu, Tianliang Huang, Yongneng Zhang, Huier Yuan, Yaqiu Hu, Tengfei Wen, Wanling Zhuang, Bozhi Cai, Xin Zhang, Jiexiong Huang, Jidong Cheng Tags: Original Article Source Type: research