A leukemogenic kinase, FIP1L1 ‐PDGFRA, and a SUMO E3 ligase, PIAS1, form a positive crosstalk via their enzymatic activities

In conclusion, our results suggest that sumoylation by PIAS1 is a potential target in the treatment of FIP1L1‐PDGFRA‐positive chronic eosinophilic leukemia.
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Source: Cancer Science - December 12, 2016 Category: Cancer & Oncology Authors: Makoto Ibata, Junko Iwasaki, Yoichiro Fujioka, Koji Nakagawa, Stephanie Darmanin, Masahiro Onozawa, Daigo Hashimoto, Yusuke Ohba, Shigetsugu Hatakeyama, Takanori Teshima, Takeshi Kondo Tags: Original Article Source Type: research