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Condition: Stroke
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Total 302 results found since Jan 2013.
Nicotinamide Mononucleotide Adenylyltransferase 1 Regulates Cerebral Ischemia –Induced Blood–Brain Barrier Disruption Through NAD+/SIRT1 Signaling Pathway
In conclusion, these findings indicate that rh-NMNAT1 protects BBB integrity after cerebral ischemia via the NAD+/SIRT1 signaling pathway in brain microvascular endothelial cells. NMNAT1 may be a novel potential therapeutic target for reducing BBB disruption after ischemic stroke.
Source: Molecular Neurobiology - June 3, 2022 Category: Neurology Source Type: research
Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway
CONCLUSIONS: These results indicate that cornin improved neurological recovery after cerebral ischemia injury by preventing astrocytes autophagy induced by CI/R via the PI3K/Akt/mTOR signaling pathway.PMID:36280856 | DOI:10.1186/s40360-022-00620-3
Source: BMC Pharmacology and Toxicology - October 25, 2022 Category: Drugs & Pharmacology Authors: Tianchi Lan Yangyang Xu Shucui Li Ning Li Shuping Zhang Haibo Zhu Source Type: research
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination
This study explores the relationship between HECTD4, GluN2B, and MALT1, focusing on their role in brain injury in ischemic stroke. Rats were subjected to 2 h-ischemia followed by 24-h reperfusion to establish an ischemic stroke model. We observed the downregulation of HECTD4 and the upregulation of MALT1. Additionally, an increased GluN2B phosphorylation was concomitant with weakened interactions between HECTD4 and GluN2B, followed by decreased stria tal-enriched protein phosphatase (STEP61). Knockdown of HECTD4 exacerbated hypoxia- or NMDA-induced injury in nerve cells coincident with a decrease in GluN2B and MALT1 ubiq...
Source: Molecular Neurobiology - February 4, 2023 Category: Neurology Source Type: research
Tetramethylpyrazine Attenuates Oxygen-glucose Deprivation-induced Neuronal Damage through Inhibition of the HIF-1 α/BNIP3 Pathway: From Network Pharmacological Finding to Experimental Validation
CONCLUSION: Our study shows that TMP protects OGD-damaged PC12 cells by inhibiting the HIF-1α/BNIP3 pathway, which provides new insights into the mechanism of TMP and its neuroprotective potential.PMID:36790003 | DOI:10.2174/1381612829666230215100507
Source: Current Pharmaceutical Design - February 15, 2023 Category: Drugs & Pharmacology Authors: Shixin Xu Nannan Zhang Lanlan Cao Lu Liu Hao Deng Shengyu Hua Yunsha Zhang Source Type: research
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination
This study explores the relationship between HECTD4, GluN2B, and MALT1, focusing on their role in brain injury in ischemic stroke. Rats were subjected to 2 h-ischemia followed by 24-h reperfusion to establish an ischemic stroke model. We observed the downregulation of HECTD4 and the upregulation of MALT1. Additionally, an increased GluN2B phosphorylation was concomitant with weakened interactions between HECTD4 and GluN2B, followed by decreased stria tal-enriched protein phosphatase (STEP61). Knockdown of HECTD4 exacerbated hypoxia- or NMDA-induced injury in nerve cells coincident with a decrease in GluN2B and MALT1 ubiq...
Source: Molecular Neurobiology - March 1, 2023 Category: Neurology Source Type: research
Calmodulin Kinase IV‐dependent CREB activation is required for neuroprotection via NMDA receptor‐PSD95 disruption
This study highlights the importance of maintaining neuronal function following ischemic injury. Future stroke research should target neurotrophic and pro‐survival signal pathways in the development of novel neuroprotective strategies.
© 2013 International Society for Neurochemistry, J. Neurochem. (2013) 10.1111/jnc.12176
Source: Journal of Neurochemistry - January 31, 2013 Category: Neurology Authors: Karen F. S. Bell, Russell J. Bent, Saira Meese‐Tamuri, Alicia Ali, Joan P. Forder, Michelle M. Aarts Tags: Original Article Source Type: research
Calmodulin Kinase IV–dependent CREB activation is required for neuroprotection via NMDA receptor‐PSD95 disruption
This study highlights the importance of maintaining neuronal function following ischaemic injury. Future stroke research should target neurotrophic and pro‐survival signal pathways in the development of novel neuroprotective strategies.
We propose that uncoupling NMDA receptors from PSD95 provides neuroprotection from stroke by enhancing Ca2+/Calmodulin‐dependent neurotrophic signalling. Blocking NMDAR‐PSD95 interactions allows enhanced activation of nuclear CaM‐kinase IV and prolonged phosphorylation of the CREB transcription factor, resulting in enhanced neurotrophic transcription. These findings demonstrate the...
Source: Journal of Neurochemistry - March 3, 2013 Category: Neurology Authors: Karen F. S. Bell, Russell J. Bent, Saira Meese‐Tamuri, Alicia Ali, Joan P. Forder, Michelle M. Aarts Tags: Original Article Source Type: research
Activation of STAT3 is involved in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptors in rats.
In conclusion, EA pretreatment enhances STAT3 activation via CB1R to protect against cerebral ischemia, suggesting that STAT3 activation may be a novel target for stroke intervention.
PMID: 23880371 [PubMed - as supplied by publisher]
Source: Brain Research - July 20, 2013 Category: Neurology Authors: Zhou H, Zhang Z, Wei H, Wang F, Guo F, Gao Z, Marsicano G, Wang Q, Xiong L Tags: Brain Res Source Type: research
Ion transporters in brain endothelial cells that contribute to formation of brain interstitial fluid.
Abstract
Ions and water transported across the endothelium lining the blood-brain barrier contribute to the fluid secreted into the brain and are important in maintaining appropriate volume and ionic composition of brain interstitial fluid. Changes in this secretion process may occur after stroke. The present study identifies at transcript and protein level ion transporters involved in the movement of key ions and examines how levels of certain of these alter following oxidative stress. Immunohistochemistry provides evidence for Cl(-)/HCO3 (-) exchanger, AE2, and Na(+), HCO3 (-) cotransporters, NBCe1 and NBCn1, on...
Source: Pflugers Archiv : European Journal of Physiology - September 11, 2013 Category: Physiology Authors: Mokgokong R, Wang S, Taylor CJ, Barrand MA, Hladky SB Tags: Pflugers Arch Source Type: research
Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 20, 2013 Category: Neurology Authors: Ying‐Na Li, Rong Pan, Xu‐Jun Qin, Wei‐Lin Yang, Zhifeng Qi, Wenlan Liu, Ke Jian Liu Tags: Original Article Source Type: research
Stat3 mediates LIF‐induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool
Reactive oxygen species (ROS) have been implicated in various types of CNS damage, including stroke. We used a cultured astrocyte model to explore mechanisms of survival of CNS cells following ROS damage. We found that pretreatment with leukemia inhibitory factor (LIF) preserves astrocytes exposed to toxic levels of t‐BHP by inhibiting an increase in intracellular ROS following t‐BHP treatment. Astrocytes lacking functional Stat3 did not benefit from the pro‐survival or antioxidant effects of LIF. Inhibition of mitochondrial uncoupling protein 2 (UCP2) using a chemical inhibitor or siRNA abrogates the prosurvival eff...
Source: Glia - December 5, 2013 Category: Neurology Authors: Daniel W. Lapp, Samuel S. Zhang, Colin J. Barnstable Tags: Research Article Source Type: research
Integrin β3 mediated cerebrovascular remodeling through Src/ClC‐3 volume regulated Cl‐ channel signalling pathway
Conclusions and ImplicationsIntegrin β3 mediated cerebrovascular remodeling during hypertension via Src/ClC‐3 signalling pathway.
Source: British Journal of Pharmacology - February 25, 2014 Category: Drugs & Pharmacology Authors: Jia‐Wei Zeng, Xiao‐Guang Wang, Ming‐Ming Ma, Xiao‐Fei Lv, Jie Liu, Jia‐Guo Zhou, Yong‐Yuan Guan Tags: Research Paper Source Type: research
Down-Regulation of miRNA-30a Alleviates Cerebral Ischemic Injury Through Enhancing Beclin 1-Mediated Autophagy.
In this study, the effects of miRNA-30a on ischemic injury in N2A cells and cultured cortical neurons after oxygen glucose deprivation (OGD), and mouse brain with MCAO-induced ischemic stroke were evaluated. The results showed that miRNA-30a expression levels were up regulated in the brain of mice after 6 h MCAO without reperfusion, but significantly down regulated in the peri-infarct region of mice with 1 h MCAO/24 h reperfusion and in N2A cells after 1 h OGD/6-48 h reoxygenation. Both the conversion ratio of microtubule-associated protein 1 light chain 3 (LC3)-II/LC3-I and Beclin 1 protein level increased in N2A cel...
Source: Neurochemical Research - April 26, 2014 Category: Neuroscience Authors: Wang P, Liang J, Li Y, Li J, Yang X, Zhang X, Han S, Li S, Li J Tags: Neurochem Res Source Type: research
