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iTRAQ-and LC-MS/MS-based quantitative proteomics reveals Pqlc2 as a potential regulator ofhepatic glucose metabolism and insulin signaling pathway during fasting.
In conclusion, our study provides important information onprotein profile change during prolonged fasting with iTRAQ-and LC-MS/MS-based quantitative proteomics, and identifies Pqlc2 as a potential regulator of hepatic glucose metabolism and insulin signaling pathwayin this process. PMID: 33051888 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - October 13, 2020 Category: Drugs & Pharmacology Authors: Sun DY, Fu JT, Li GQ, Zhang WJ, Zeng FY, Tong J, Miao CY, Li DJ, Wang P Tags: Clin Exp Pharmacol Physiol Source Type: research

Berberine improves insulin resistance in adipocyte models by regulating the methylation of hypoxia-inducible factor-3 α.
Berberine improves insulin resistance in adipocyte models by regulating the methylation of hypoxia-inducible factor-3α. Biosci Rep. 2019 Oct 30;39(10): Authors: Wang Y, Gong W, Lv S, Qu H, He Y Abstract Methylation of hypoxia-inducible factor-3α (HIF3A) was previously demonstrated to be highly associated with insulin resistance (IR) in patients with gestational diabetes mellitus (GDM). We aimed to study the therapeutic effects of Berberine (BBR) on GDM and the possible mechanisms. The expressions and methylated states of HIF3A in pregnant women with GDM were compared with that in healthy controls. T...
Source: Bioscience Reports - October 29, 2019 Category: Biomedical Science Authors: Wang Y, Gong W, Lv S, Qu H, He Y Tags: Biosci Rep Source Type: research

miRNA-218 Targets Lipin-1 and Glucose Transporter Type 4 Genes in 3T3-L1 Cells Treated With Lopinavir/Ritonavir
Conclusion: 3T3-L1 cells, treated with LPV/RTV, show altered lipid content due to increased miRNA-218 levels, which affects lipin-1 mRNA. Moreover, increased miRNA-218 levels were inversely correlated with changes in GLUT-4 expression, which suggests a role for miRNA-218 in mediating the insulin resistance consequent to cART. Introduction Metabolic syndrome is a serious consequence of combined Antiretroviral Therapy (cART). HIV-associated metabolic syndrome is often accompanied by lipodystrophy (LS), the redistribution of body fat with loss of subcutaneous adipose tissue in face, limbs and buttocks, concomitant wit...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Ability to Suppress TGF- β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions
Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD. Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic ...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Role of plasminogen activator inhibitor-1 in glucocorticoid-induced muscle change in mice
In conclusion, our data suggest that paracrine PAI-1 is involved in GC-induced muscle wasting through the enhancement of muscle degradation in mice.
Source: Journal of Bone and Mineral Metabolism - March 19, 2017 Category: Orthopaedics Source Type: research

Reduced Insulin Receptor Expression Enhances Proximal Tubule Gluconeogenesis
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - June 20, 2016 Category: Biochemistry Authors: Gaurav Pandey, Kripa Shankar, Ekta Makhija, Anil Gaikwad, Carolyn Ecelbarger, Anil Mandhani, Aneesh Srivastava, Swasti Tiwari Tags: Article Source Type: research

PGC-1α is responsible for survival of multiple myeloma cells under hyperglycemia and chemotherapy.
Authors: Yu W, Cao D, Zhou H, Hu Y, Guo T Abstract The association between hyperglycemia and outcomes during chemotherapy has been reported in several tumors, including multiple myeloma (MM). However, the underlying mechanism of how hyperglycemia affects the survival of MM cells during chemotherapy remain to be elucidated. MM cells were cultured in 10 mM glucose with or without chemotherapeutic agents. Following treatment of MM cells with dexamethasone or bortezomib, an MTT assay was used to evaluate the toxicity of dexamethasone or bortezomib on cell proliferation, and changes of reactive oxygen species (ROS) lev...
Source: Oncology Reports - February 21, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Upregulation of p21 activates the intrinsic apoptotic pathway in beta cells.
Abstract Diabetes manifests from a loss in functional beta cell mass, which is regulated by a dynamic balance of various cellular processes including beta cell growth, proliferation, and death as well as secretory function. The cell cycle machinery comprised of cyclins, kinases, and inhibitors regulate proliferation. However, their involvement during beta cell stress during the development of diabetes is not well understood. Interestingly, in a screen of multiple cell cycle inhibitors, p21 was dramatically upregulated in INS-1-derived 832/13 cells and rodent islets by two pharmacologic inducers of beta cell stress...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 16, 2013 Category: Physiology Authors: Hernandez AM, Colvin ES, Chen YC, Geiss SL, Eller LE, Fueger PT Tags: Am J Physiol Endocrinol Metab Source Type: research