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Condition: Heart Failure
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Total 253 results found since Jan 2013.
GRK5 Regulation of NF-{kappa}B Signaling Signal Transduction
G protein-coupled receptor kinase 5 GRK5 plays a key role in regulating cardiac signaling and its expression is increased in heart failure. GRK5 activity in the nucleus of myocytes has been shown to be detrimental in the setting of pressure-overload hypertrophy. The ubiquitous nuclear transcription factor κB (NF-κB) is involved in the regulation of numerous genes in various tissues, and activation of NF-κB has been shown to be associated with heart disease. Herein, we investigated whether GRK5 can specifically regulate the NF-κB signaling pathway in myocytes. We found that overexpression of GRK5 increased the levels of...
Source: Journal of Biological Chemistry - December 13, 2013 Category: Chemistry Authors: Islam, K. N., Bae, J.-W., Gao, E., Koch, W. J. Tags: Gene Regulation Source Type: research
Apelin inhibits the proliferation and migration of rat PASMCs via the activation of PI3K/Akt/mTOR signal and the inhibition of autophagy under hypoxia
This study provides the evidence that exogenous apelin treatment contributes to inhibit the proliferation and migration of PASMCs by regulating the level of autophagy.
Source: Journal of Cellular and Molecular Medicine - January 22, 2014 Category: Molecular Biology Authors: Hongyu Zhang, Yongsheng Gong, Zhouguang Wang, Liping Jiang, Ran Chen, Xiaofang Fan, Huanmian Zhu, Liping Han, Xiaokun Li, Jian Xiao, Xiaoxia Kong Tags: Original Article Source Type: research
Apelin inhibits the proliferation and migration of rat PASMCs via the activation of PI3K/Akt/mTOR signal and the inhibition of autophagy under hypoxia.
This study provides the evidence that exogenous apelin treatment contributes to inhibit the proliferation and migration of PASMCs by regulating the level of autophagy.
PMID: 24447518 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - January 22, 2014 Category: Molecular Biology Authors: Zhang H, Gong Y, Wang Z, Jiang L, Chen R, Fan X, Zhu H, Han L, Li X, Xiao J, Kong X Tags: J Cell Mol Med Source Type: research
Gelsolin (GSN) induces cardiomyocyte hypertrophy and BNP expression via p38 signaling and GATA-4 transcriptional factor activation.
In this study, we used H9c2 and H9c2-GSN stable clones in an attempt to understand the mechanisms of GSN overexpression in cardiomyocytes. These data showed that the overexpression of GSN in H9c2-induced cardiac hypertrophy and increased the pathological hypertrophy markers atrial natriuretic peptide brain natriuretic peptide. Furthermore, we found that E-cadherin expression decreased with the overexpression of GSN in H9c2, but β-catenin expression increased. These data presume that the cytoskeleton is loose. Further, previous studies show that the mitogen-activated protein kinase pathway can induce cardiac hypertrophy. O...
Source: Molecular and Cellular Biochemistry - February 7, 2014 Category: Biochemistry Authors: Hu WS, Ho TJ, Pai P, Chung LC, Kuo CH, Chang SH, Tsai FJ, Tsai CH, Jie YC, Liou YM, Huang CY Tags: Mol Cell Biochem Source Type: research
MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure
Conclusions: MicroRNA-150 counteracts ADIPOR2 up-regulation in CHF and thus may contribute to adiponectin resistance. Targeting microRNA-150 may be a future strategy to restore cardioprotective adiponectin effects.
Source: The Journal of Heart and Lung Transplantation - October 28, 2013 Category: Transplant Surgery Authors: Simone Kreth, Carola Ledderose, Stefanie Schütz, Andres Beiras, Jens Heyn, Florian Weis, Andres Beiras-Fernandez Tags: Featured Articles Source Type: research
Resveratrol‐enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice
Abstract
Autophagic dysfunction is observed in diabetes mellitus. Resveratrol has a beneficial effect on diabetic cardiomyopathy. Whether the resveratrol‐induced improvement in cardiac function in diabetes is via regulating autophagy remains unclear. We investigated the mechanisms underlying resveratrol‐mediated protection against heart failure in diabetic mice, with a focus on the role of sirtuin 1 (SIRT1) in regulating autophagic flux. Diabetic cardiomyopathy in mice was induced by streptozotocin (STZ). Long‐term resveratrol treatment improved cardiac function, ameliorated oxidative injury and reduced apoptosis in ...
Source: Journal of Cellular and Molecular Medicine - June 1, 2014 Category: Molecular Biology Authors: Bo Wang, Qing Yang, Yuan‐yuan Sun, Yi‐fan Xing, Ying‐bin Wang, Xiao‐ting Lu, Wen‐wu Bai, Xiao‐qiong Liu, Yu‐xia Zhao Tags: Original Article Source Type: research
Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice.
Abstract
Autophagic dysfunction is observed in diabetes mellitus. Resveratrol has a beneficial effect on diabetic cardiomyopathy. Whether the resveratrol-induced improvement in cardiac function in diabetes is via regulating autophagy remains unclear. We investigated the mechanisms underlying resveratrol-mediated protection against heart failure in diabetic mice, with a focus on the role of sirtuin 1 (SIRT1) in regulating autophagic flux. Diabetic cardiomyopathy in mice was induced by streptozotocin (STZ). Long-term resveratrol treatment improved cardiac function, ameliorated oxidative injury and reduced apoptosis ...
Source: J Cell Mol Med - June 1, 2014 Category: Molecular Biology Authors: Wang B, Yang Q, Sun YY, Xing YF, Wang YB, Lu XT, Bai WW, Liu XQ, Zhao YX Tags: J Cell Mol Med Source Type: research
Bone Morphogenetic Protein‐10 induces cardiomyocyte proliferation and improves cardiac function after myocardial infarction
Heart disease is among the leading causes of death worldwide, and the limited proliferation of mammalian cardiomyocytes prevents heart regeneration in response to injury. Bone morphogenetic protein‐10 (BMP10) exerts multiple roles in various developmental events; however, the effect of BMP10 and the underlying mechanism involved in cardiac repair remains unclear. After stimulation with the recombinant BMP10, an obvious dose‐dependent cardiomyocyte proliferation and reentry of differentiated mammalian cardiomyocytes into the cell cycle was observed. Furthermore, BMP10 stimulation strikingly enhanced Tbx20 expression. Fu...
Source: Journal of Cellular Biochemistry - June 6, 2014 Category: Biochemistry Authors: Lijun Sun, Jing Yu, Shun Qi, Yuewen Hao, Ying Liu, Zhenwu Li Tags: Article Source Type: research
Cardioprotective Effect of the Selective Sigma-1 Receptor Agonist, SA4503.
Abstract
We previously reported that the sigma-1 receptor is down-regulated in cardiomyocytes following heart failure in transverse aortic constriction (TAC) mice. In this review, we summarized the anti-hypertrophic action of selective sigma-1 receptor agonist, SA4503 in the hypertrophied cultured cardiomyocytes and discussed its possible mechanism of cardioprotection. Treatment with SA4503 (0.1-1 μM) dose-dependently inhibited hypertrophy in cultured cardiomyocytes induced by angiotensin II (Ang II). We also found that α1 receptor stimulation by phenylephrine (PE) promotes ATP production through IP3 recepto...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 8, 2014 Category: Drugs & Pharmacology Authors: Hirano K, Tagashira H, Fukunaga K Tags: Yakugaku Zasshi Source Type: research
Insulin, NF-{kappa}B, and Myocardin Signaling in Cardiac Myoblasts Signal Transduction
Hyperinsulinemia contributes to cardiac hypertrophy and heart failure in patients with the metabolic syndrome and type 2 diabetes. Here, high circulating levels of tumor necrosis factor (TNF)-α may synergize with insulin in signaling inflammation and cardiac hypertrophy. We tested whether high insulin affects activation of TNF-α-induced NF-κB and myocardin/serum response factor (SRF) to convey hypertrophy signaling in cardiac myoblasts. In canine cardiac myoblasts, treatment with high insulin (10−8 to 10−7 m) for 0–24 h increased insulin receptor substrate (IRS)-1 phosphorylation at Ser-307, decreased protein leve...
Source: Journal of Biological Chemistry - July 10, 2014 Category: Chemistry Authors: Madonna, R., Geng, Y.-J., Bolli, R., Rokosh, G., Ferdinandy, P., Patterson, C., De Caterina, R. Tags: Gene Regulation Source Type: research
Sumo E2 Ligase UBC9 is Required for Efficient Protein Quality Control in Cardiomyocytes.
Conclusions: UBC9 plays a significant role in cardiomyocyte PQC and its activity can be exploited to reduce toxic levels of misfolded or aggregated proteins in cardiomyopathy.
PMID: 25097219 [PubMed - as supplied by publisher]
Source: Circulation Research - August 5, 2014 Category: Cardiology Authors: Gupta MK, Gulick J, Liu R, Wang X, Molkentin JD, Robbins J Tags: Circ Res Source Type: research
AT2 Receptor Potentiates Skeletal Muscle Regeneration Cell Biology
Patients with advanced congestive heart failure (CHF) or chronic kidney disease (CKD) often have increased angiotensin II (Ang II) levels and cachexia. Ang II infusion in rodents causes sustained skeletal muscle wasting and decreases muscle regenerative potential through Ang II type 1 receptor (AT1R)-mediated signaling, likely contributing to the development of cachexia in CHF and CKD. However, the potential role of Ang II type 2 receptor (AT2R) signaling in skeletal muscle physiology is unknown. We found that AT2R expression was increased robustly in regenerating skeletal muscle after cardiotoxin (CTX)-induced muscle inju...
Source: Journal of Biological Chemistry - September 18, 2014 Category: Chemistry Authors: Yoshida, T., Huq, T. S., Delafontaine, P. Tags: Molecular Bases of Disease Source Type: research
Improving heart function by modulating myocardiocyte autophagy: a possible novel mechanism for cardiovascular protection of high-density lipoprotein
Background:
High-density lipoprotein (HDL) has been shown to confer cardiovascular protection in clinical and epidemiologic studies. Emerging evidence suggests that many of the cardioprotective functions of HDL may be due to the phospholipid sphingosine-1-phosphate (S1P).Presentation of the hypothesisHDL-S1P binds to S1P receptors in the heart, activating PI3K/Akt signaling and myocyte survival. PI3K/Akt is a classic signaling modulator of autophagy. Excessive autophagy due to cell death and cardiomyocyte loss may contribute to impaired heart function during pressure overload-induced heart failure. Therefore, we hypothesiz...
Source: Lipids in Health and Disease - October 22, 2014 Category: Lipidology Authors: Fan WangPing Ye Source Type: research
Contribution of neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts.
In conclusion, we have discovered Nav1.1-originated INaL component in dog heart ventricular cells. This component is physiologically relevant to control AP shape and duration, as well as to cell Ca(2+) dynamics. This article is protected by copyright. All rights reserved.
PMID: 25326451 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - October 17, 2014 Category: Physiology Authors: Mishra S, Reznikov V, Maltsev VA, Undrovinas NA, Sabbah HN, Undrovinas A Tags: J Physiol Source Type: research
Genistein alleviates pressure overload‐induced cardiac dysfunction and interstitial fibrosis in mice
CONCLUSIONS AND IMPLICATIONSGen improved cardiac function and inhibited cardiac fibrosis in response to pressure overload. The underlying mechanism may involve regulation of the MTA3/TAK1/MKK4/JNK signaling pathway. Gen may serve as a novel agent for prevention and therapy of cardiac disorders associated with fibrosis.
Source: British Journal of Pharmacology - November 3, 2014 Category: Drugs & Pharmacology Authors: Wei Qin, Ning Du, Longyin Zhang, Xianxian Wu, Yingying Hu, Xiaoguang Li, Nannan Shen, Yang Li, Baofeng Yang, Chaoqian Xu, Zhiwei Fang, Yanjie Lu, Yong Zhang, Zhimin Du Tags: Research Paper – Chinese innovation in cardiovascular drug Discovery Themed Issue Source Type: research
