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Condition: Autoimmune Disease

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Total 230 results found since Jan 2013.

Phosphatase control of cytokine-mediated overproduction of galactose-deficient IgA1, the main autoantigen in IgA nephropathy
J Autoimmun. 2022 Aug 17;132:102883. doi: 10.1016/j.jaut.2022.102883. Online ahead of print.ABSTRACTIgA nephropathy (IgAN) is an autoimmune disease characterized by the deposition of galactose-deficient IgA1 (Gd-IgA1)-containing immune complexes in the kidneys. Elevated serum levels of Gd-IgA1, the main autoantigen in IgAN, are associated with mucosal infections and poor renal outcome in IgAN patients, but little is known about the activation of IgA1-secreting cells overproducing this autoantigen. We found that in peripheral blood mononuclear cells (PBMCs), cytokine stimulation elevated Gd-IgA1 production in B cells from I...
Source: Journal of Autoimmunity - August 20, 2022 Category: Allergy & Immunology Authors: Colin Reily Terri Rice David K Crossman Dana V Rizk Source Type: research

Inhibitor of nuclear factor kappa ‐B kinase epsilon contributes to neuropsychiatric manifestations in lupus‐prone mice through microglial activation
ConclusionsThese findings suggest that IKBKE plays a vital role in the pathogenesis of NPSLE via microglial activation, and it could serve as a therapeutic target for NPSLE.
Source: Arthritis and Rheumatology - September 13, 2022 Category: Rheumatology Authors: Kohei Karino, Michihito Kono, Shuhei Takeyama, Yuki Kudo, Masatoshi Kanda, Nobuya Abe, Kuniyuki Aso, Yuichiro Fujieda, Masaru Kato, Kenji Oku, Olga Amengual, Tatsuya Atsumi Tags: Full Length Source Type: research

Acid sensor ASIC1a induces synovial fibroblast proliferation via Wnt/ β-catenin/c-Myc pathway in rheumatoid arthritis
Int Immunopharmacol. 2022 Oct 21;113(Pt A):109328. doi: 10.1016/j.intimp.2022.109328. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and progressive joint destruction in the middle and late stages. Notably, activated rheumatoid arthritis synovial fibroblasts (RASFs) exhibit tumor-like features, including an increased proliferation rate that largely contributes to pannus formation and joint destruction. Our previous studies have demonstrated that acid-sensing ion channel 1a (ASIC1a) was highly expressed in RASFs, and acidic microenvironment of sy...
Source: International Immunopharmacology - October 24, 2022 Category: Allergy & Immunology Authors: Yayun Xu Zheng Lu Yian Ling Ruirui Hou Jingjing Tao Ge Deng Xiaoling Xu Xuewei Chen Jingjing Ruan Yihao Zhang Xiaoqing Peng Feihu Chen Source Type: research

Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway
In this study, we carried out histological and physiological analyses in UC patients and UC mice. RNA sequencing (RNA-seq), assays for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq), chromatin immunoprecipitation (ChIP) assays and protein and mRNA expression were performed to analyze and identify the potential molecular mechanism in UC mice and lipopolysaccharide (LPS)-induced mouse intestinal epithelial cells (MIECs). Moreover, we established nucleotide-binding oligomerization domain (NOD)-like receptor protein nlrp6-/- mice and siRNA-NLRP6 MIECs to further characterize the role of NLRP6 in an...
Source: Frontiers in Immunology - February 8, 2023 Category: Allergy & Immunology Source Type: research

CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren ’s Syndrome by Activating GRK2 to Promote T Lymphocyte Migration
AbstractPrimary Sjogren ’s syndrome (pSS) is a systemic autoimmune disease that causes dysfunction of secretory glands and the specific pathogenesis is still unknown. The CXCL9, 10, 11/CXCR3 axis and G protein-coupled receptor kinase 2 (GRK2) involved in many inflammation and immunity processes. We used NOD/Ltj mice, a s pontaneous SS animal model, to elucidate the pathological mechanism of CXCL9, 10, 11/CXCR3 axis promoting T lymphocyte migration by activating GRK2 in pSS. We found that CD4 + GRK2, Th17 + CXCR3 was apparently increased and Treg + CXCR3 was significantly decreased in the spleen of 4W NOD mice...
Source: Inflammation - February 18, 2023 Category: Allergy & Immunology Source Type: research

Excessive iodine induces thyroid follicular epithelial cells apoptosis by activating HIF-1 α-mediated hypoxia pathway in Hashimoto thyroiditis
CONCLUSION: Our study confirmed that excessive iodine adsorption activates the HIF-1α-mediated hypoxia pathway to promote apoptosis of TFCs, which may be an important risk factor contributing to HT development.PMID:36807042 | DOI:10.1007/s11033-023-08273-z
Source: Molecular Biology Reports - February 22, 2023 Category: Molecular Biology Authors: Lili Zhang Xiaojing Sun Lin Liu Ping Wang Linxue Qian Source Type: research

m < sup > 6 < /sup > A methyltransferase METTL3 programs CD4 < sup > + < /sup > T-cell activation and effector T-cell differentiation in systemic lupus erythematosus
CONCLUSION: In summary, our findings demonstrated that METTL3 was required for stabilizing Foxp3 mRNA via m6A modification to maintain the Treg differentiation program. METTL3 inhibition contributed to the pathogenesis of SLE by participating in the activation of CD4+ T cells and imbalance of effector T-cell differentiation, which could serve as a potential target for therapeutic intervention in SLE.PMID:37013484 | DOI:10.1186/s10020-023-00643-4
Source: Molecular Medicine - April 4, 2023 Category: Molecular Biology Authors: Shuang Lu Xingyu Wei Huan Zhu Zhi Hu Meiling Zheng Jiali Wu Cheng Zhao Shuang Yang Delong Feng Sujie Jia Hongjun Zhao Ming Zhao Source Type: research

1099 Rational development of JAK1-selective siRNA therapeutics for the treatment of autoimmune skin diseases
JAK inhibition has surged as a popular treatment strategy for many inflammatory and autoimmune skin diseases. Current available small molecule JAK inhibitors in the clinic show distinct efficacy and safety profiles, likely reflecting their selectivity for certain JAK subtypes (i.e., JAK1, JAK2, JAK3, and tyrosine kinase 2 —TYK2). Achieving absolute JAK subtype selectivity remains challenging. RNA therapeutics, such as mRNAs, small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs), and aptamers, are a new generation of drug modality expected to dramatically accelerate the development of human medicine.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: Q. Tang, H. Fakih, M. Zain Ul Abideen, K. Afshari, K. Gross, J. Alterman, A. Khvorova, J.E. Harris Source Type: research

Mettl14 sustains FOXP3 expression to promote the differentiation and functions of induced-regulatory T cells via the mTOR signaling pathway
In conclusion, our study revealed that Mettl14 plays a critical role in the development and suppressive function of iTregs in vitro and could thus serve as a regulatory element for stabilizing iTregs in cell-based therapy.PMID:37121553 | DOI:10.1016/j.imlet.2023.04.008
Source: Immunology Letters - April 30, 2023 Category: Allergy & Immunology Authors: Yanzhuo Liu Yinglin Yuan Zili Zhou Xiaomei Jiang Shu He Fan Wei Yuanyuan Cui Lu Yang Gaoping Zhao Source Type: research