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Condition: Spinal Cord Injury
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Total 126 results found since Jan 2013.
Suppression of microglial Ccl2 reduces neuropathic pain associated with chronic spinal compression
ConclusionDisc microglia expressing high levels of Ccl2 may contribute to chronic spinal compression and SCI-associated pain. Therapeutically targeting Ccl2 in microglia could offer a potential avenue for treating chronic spinal compression and SCI-associated pain.
Source: Frontiers in Immunology - July 11, 2023 Category: Allergy & Immunology Source Type: research
Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway
CONCLUSION: PXR is involved in the recovery of motor function after SCI by regulating NRF2/HO-1 pathway.PMID:37269088 | DOI:10.1111/cns.14279
Source: CNS Neuroscience and Therapeutics - June 3, 2023 Category: Neuroscience Authors: Li-Na Xuan Zhen-Xin Hu Zhen-Fu Jiang Cong Zhang Xiao-Wan Sun Wen-Hua Ming Hui-Tao Liu Rong-Fang Qiao Lin-Jie Shen Shao-Bo Liu Guan-Yu Wang Lin Wen Zhi-Lin Luan Jian Yin Source Type: research
MG53 ameliorates nerve injury induced neuropathic pain through the regulation of Nrf2/HO-1 signaling in rats
In this study, we aimed to explore the role of MG3 in neuropathic pain after chronic constriction injury (CCI) to the sciatic nerve in rats. To explore the mechanism of MG53 regulating the development of neuropathic pain, the rats was injected (intrathecal injection) of recombinant human MG53 (rhMG53) protein and/or nuclear factor erythroid 2-related factor 2 (Nrf2) siRNA after CCI. Mechanical allodynia or thermal hyperalgesia was assessed by the 50% paw withdrawal threshold (PWT) or the paw withdrawal latency (PWL). The target molecules was detected using western blotting (WB), immunofluorescence (IF), quantitative real-t...
Source: Brain Research - May 11, 2023 Category: Neurology Authors: Xuan-Zhi Zhu Jing-Qiong Wang Yao-Hua Wu Source Type: research
Emergency Treatment and Photoacoustic Assessment of Spinal Cord Injury Using Reversible Dual ‐Signal Transform‐Based Selenium Antioxidant
Schematic representation of the selenium-based antioxidant defense nanosystem Se@BDP-DOH NPs for photoacoustic monitoring of spinal cord injury. AbstractSpinal cord injury (SCI), following explosive oxidative stress, causes an abrupt and irreversible pathological deterioration of the central nervous system. Thus, preventing secondary injuries caused by reactive oxygen species (ROS), as well as monitoring and assessing the recovery from SCI are critical for the emergency treatment of SCI. Herein, an emergency treatment strategy is developed for SCI based on the selenium (Se) matrix antioxidant system to effectively inhibit ...
Source: Small - May 2, 2023 Category: Nanotechnology Authors: Zhisheng Ji,
Judun Zheng,
Yanming Ma,
Hongyi Lei,
Weiqiang Lin,
Jialin Huang,
Hua Yang,
Guowei Zhang,
Bin Li,
Bowen Shu,
Xianjin Du,
Jian Zhang,
Hongsheng Lin,
Yuhui Liao Tags: Research Article Source Type: research
CircSmox knockdown alleviates PC12 cell apoptosis and inflammation in spinal cord injury by miR ‐340‐5p/Smurf1 axis
ConclusionCircSmox enhances LPS-induced apoptosis and inflammation via miR-340-5p/Smurf1 axis, providing an exciting view of the potential involvement of circSmox in SCI pathogenesis.
Source: Immunity, Inflammation and Disease - April 12, 2023 Category: Allergy & Immunology Authors: Ziyin Han,
Zufang Mou,
Yulong Jing,
Rong Jiang,
Tao Sun Tags: ORIGINAL ARTICLE Source Type: research
Hesperetin ameliorates spinal cord injury by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling
Int Immunopharmacol. 2023 Mar 28;118:110103. doi: 10.1016/j.intimp.2023.110103. Online ahead of print.ABSTRACTNeuroinflammation is a prominent feature of traumatic spinal cord injuries (SCIs). Hesperetin exhibits anti-inflammatory effects in neurological disorders; however, the potential neuroprotective effects of hesperetin in cases of SCI remain unclear. Sprague-Dawley rats with C5 hemi-contusion injuries were used as an SCI model. Hesperetin was administered to the experimental rats in order to investigate its neuroprotective effects after SCI, and BV2 cells were pretreated with hesperetin or silencing of nuclear factor...
Source: International Immunopharmacology - March 31, 2023 Category: Allergy & Immunology Authors: Zhongyuan Liu Kewu Tu Peiqian Zou Congrui Liao Ruoting Ding Zucheng Huang Zhiping Huang Xinqiang Yao Jianting Chen Zhongmin Zhang Source Type: research
Effects of Semaphorin3A on the growth of sensory and motor neurons
Exp Cell Res. 2023 Feb 8:113506. doi: 10.1016/j.yexcr.2023.113506. Online ahead of print.ABSTRACTAfter peripheral nerve injury, motor and sensory axons can regenerate, but the inaccurate reinnervation of the target leads to poor functional recovery. Schwann cells (SCs) express sensory and motor phenotypes associated with selective regeneration. Semaphorin 3A (Sema3A) is an axonal chemorepellent that plays an essential role in axon growth. SCs can secret Sema3A, and Sema3A presents a different expression pattern at the proximal and distal ends of injured sensory and motor nerves. Hence, in our study, the protein expression ...
Source: Experimental Cell Research - February 10, 2023 Category: Cytology Authors: Mi Shen Chun Zhou Yingchao Tian Tongxin Shang None Qingyun Liang Mengru Ming Fei Ding Yuhua Ji Source Type: research
Fidgetin impacts axonal growth and branching in a local mTOR signal dependent manner
Exp Neurol. 2022 Dec 28:114315. doi: 10.1016/j.expneurol.2022.114315. Online ahead of print.ABSTRACTNeurons require a constant increase in protein synthesis during axonal growth and regeneration. AKT-mTOR is a central pathway for mammalian cell survival and regeneration. Fidgetin (Fign) is an ATP-dependent microtubule (MT)-severing enzyme whose functions are associated with neurite outgrowth, axon regeneration and cell migration. Although most previous studies have indicated that depletion of Fign is involved in those biological activities by increasing labile MT mass, it remains unknown whether mTOR activation contributes...
Source: Experimental Neurology - December 31, 2022 Category: Neurology Authors: Chao Ma Junpei Wang Qifeng Tu Ronghua Wu Xiaona Lai Ge Lin Zhangji Dong Tuchen Guan Liang Qiang Yan Liu Mei Liu Source Type: research
