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Fidgetin impacts axonal growth and branching in a local mTOR signal dependent manner
Exp Neurol. 2022 Dec 28:114315. doi: 10.1016/j.expneurol.2022.114315. Online ahead of print.ABSTRACTNeurons require a constant increase in protein synthesis during axonal growth and regeneration. AKT-mTOR is a central pathway for mammalian cell survival and regeneration. Fidgetin (Fign) is an ATP-dependent microtubule (MT)-severing enzyme whose functions are associated with neurite outgrowth, axon regeneration and cell migration. Although most previous studies have indicated that depletion of Fign is involved in those biological activities by increasing labile MT mass, it remains unknown whether mTOR activation contributes...
Source: Experimental Neurology - December 31, 2022 Category: Neurology Authors: Chao Ma Junpei Wang Qifeng Tu Ronghua Wu Xiaona Lai Ge Lin Zhangji Dong Tuchen Guan Liang Qiang Yan Liu Mei Liu Source Type: research

SUMOylation of Kir7.1 participates in neuropathic pain through regulating its membrane expression in spinal cord neurons
CONCLUSION: SUMOylation of the Kir7.1 in the spinal cord might contribute to the development of SNI-induced mechanical allodynia by decreasing the Kir7.1 surface expression in rats.PMID:35633059 | DOI:10.1111/cns.13871
Source: CNS Neuroscience and Therapeutics - May 28, 2022 Category: Neuroscience Authors: You-You Lv Han Wang Hai-Ting Fan Ting Xu Wen-Jun Xin Rui-Xian Guo Source Type: research

Fascin-1 is Highly Expressed Specifically in Microglia After Spinal Cord Injury and Regulates Microglial Migration
Recent research indicates that after spinal cord injury (SCI), microglia accumulate at the borders of lesions between astrocytic and fibrotic scars and perform inflammation-limiting and neuroprotective functions, however, the mechanism of microglial migration remains unclear. Fascin-1 is a key actin-bundling protein that regulates cell migration, invasion and adhesion, but its role during SCI has not been reported. Here, we found that at 7–14 days after SCI in mice, Fascin-1 is significantly upregulated, mainly distributed around the lesion, and specifically expressed in CX3CR1-positive microglia. However, Fascin-1 is n...
Source: Frontiers in Pharmacology - September 27, 2021 Category: Drugs & Pharmacology Source Type: research

Repair of Spinal Cord Injury by Inhibition of PLK4 Expression Through Local Delivery of siRNA-Loaded Nanoparticles
In conclusion, inhibition of PLK4 expression via siRNA-loaded nanoparticles may be a potential treatment for SCI.
Source: Journal of Molecular Neuroscience - September 1, 2021 Category: Neuroscience Source Type: research

Downregulation of LncRNA Gas5 Inhibits Apoptosis and Inflammation after Spinal Cord Ischemia-Reperfusion in Rats.
Abstract Spinal cord ischemia-reperfusion injury(SCII)affects nerve function through many mechanisms, which are complex and not fully understood. Recently, accumulating evidence has indicated that long noncoding RNAs (lncRNAs) play an increasingly important role in SCII. We investigated the role of lncRNA growth arrest-specific 5(Gas5) in a rat SCII model, and its effects on apoptosis and inflammation possibly by modulating MMP-7, cleaved caspase-3 and IL-1β. LncRNA Gas5 and MMP-7 were knocked down by intrathecal siRNA injection. Neurological assessment and TUNEL assay were performed. The RNA and protein expressi...
Source: Brain Research Bulletin - December 11, 2020 Category: Neurology Authors: Zhang Z, Li X, Chen F, Li Z, Wang D, Ren X, Ma H Tags: Brain Res Bull Source Type: research

NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia/macrophages and mice models of spinal cord injury.
CONCLUSION: NEK7 amplifies NLRP3 inflammasome pro-inflammatory signaling in BV-2 microglia cells and mice models of SCI. Therefore, agents targeting the NEK7/NLRP3 signaling offers great promise in the treatment of inflammatory response post-SCI. PMID: 33309808 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - December 9, 2020 Category: Cytology Authors: Ji X, Song Z, He J, Guo S, Chen Y, Wang H, Zhang J, Xu X, Liu J Tags: Exp Cell Res Source Type: research

Irisin Protects Against Motor Dysfunction of Rats with Spinal Cord Injury via Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase-Nuclear Factor Kappa-B Pathway
The aim of the present research was to investigate the effects of irisin, a skeletal muscle-derived myokine, on spinal cord injury (SCI) in rats and explore the possible mechanisms. SCI model was constructed in male SD rats. The effects of irisin on SCI rats were assessed via behavior tests including Basso, Beattie, and Bresnahan (BBB) scoring method and inclined plane test, followed by histomorphology tests including HE staining, Nissl staining, and transmission electron microscope examination. Biochemical analyses including PCR, Western blots and ELISA were employed to further evaluate the changes at molecular level of S...
Source: Frontiers in Pharmacology - November 16, 2020 Category: Drugs & Pharmacology Source Type: research

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