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Specialty: Molecular Biology
Cancer: Colon Cancer

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Total 42 results found since Jan 2013.

ARID1A downregulation promotes cell proliferation and migration of colon cancer via VIM activation and CDH1 suppression
In this study, we investigated the ARID1A-VIM/CDH1 signalling axis's role in colon cancer proliferation and migration. The differentially expressed genes in cells that might be controlled by ARID1A were discovered by a database screening for ARID1A knockout. qPCR was used to analyse ARID1A and EMT markers expression levels in colon cancer. We utilized siRNA RID1A to explore the influence of ARID1A silencing on EMT in CRC cells. The function of ARID1A in the colon was investigated utilizing the wound healing, transwell and CCK-8 WST- assays. The molecular mechanism by which ARID1A regulates VIM and CDH1 was elucidated using...
Source: Molecular Medicine - November 24, 2022 Category: Molecular Biology Authors: Salem Baldi Qianshi Zhang Zhenyu Zhang Mohammed Safi Hassan Khamgan Han Wu Mengyan Zhang Yuanyuan Qian Yina Gao Abdullah Shopit Abdullah Al-Danakh Mohammed Alradhi Murad Al-Nusaif Yunfei Zuo Source Type: research

Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway
CONCLUSION: RPL5 promoted colon cell proliferation and migration, at least in part, by activating the MAPK/ERK signaling pathway, which may serve as a novel therapeutic target for cancers in which MAPK/ERK signaling is a dominant feature.PMID:36384455 | PMC:PMC9670436 | DOI:10.1186/s12860-022-00448-z
Source: Mol Biol Cell - November 17, 2022 Category: Molecular Biology Authors: Huahua Zhang Junli Liu Qingqing Dang Xueru Wang Jie Chen Xiaoyin Lin Na Yang Juan Du Haiyan Shi Yong Liu Jiming Han Source Type: research

Worenine reverses the Warburg effect and inhibits colon cancer cell growth by negatively regulating HIF-1alpha
CONCLUSION: It is suggested that worenine targets HIF-1α to inhibit colorectal cancer cell growth, proliferation, cell cycle progression and the Warburg effect.PMID:34006215 | DOI:10.1186/s11658-021-00263-y
Source: Mol Biol Cell - May 19, 2021 Category: Molecular Biology Authors: Lijiang Ji Weixing Shen Feng Zhang Jie Qian Jie Jiang Liping Weng Jiani Tan Liu Li Yugen Chen Haibo Cheng Dongdong Sun Source Type: research

Mesenchymal stroma/stem-like cells of GARP knockdown inhibits cell proliferation and invasion of mouse colon cancer cells (MC38) through exosomes.
In conclusion, MSC-derived exosomes targeting GARP are a potential strategy for cancer therapy. PMID: 33155413 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - November 5, 2020 Category: Molecular Biology Authors: Xing H, Liang C, Xu X, Sun H, Ma X, Jiang Z Tags: J Cell Mol Med Source Type: research

Knockdown of Angiopoietin-like protein 4 suppresses the development of colorectal cancer.
Authors: Wen L, Zhang Y, Yang B, Han F, Ebadi AG, Toughani M Abstract Colorectal cancer, is the growth of cancer cells in the part of the colon. Angiopeptin is one of the growth factors in the human body that is particularly effective in the regulatory process. In this research, the regulatory role and its mechanism of Angiopoietin-like protein 4 (ANGPTL4) in colorectal cancer (CRC) metastasis, has been studied. Protein expression of ANGPLT4 was analyzed by immunohistochemistry in tumor samples and adjacent normal specimens of 40 patients with CRC cancer of various phases. A gene knockout test was conducted, two ef...
Source: Cellular and Molecular Biology - October 14, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Inhibition of semaphorin 4D enhances chemosensitivity by increasing 5-fluorouracile-induced apoptosis in colorectal cancer cells.
This study implicates that the silencing of SEMA4D by siRNA promotes the chemosensitivity of SW48 cells to 5-FU and it may be a potential therapeutic agent for colon cancer therapy. PMID: 32888127 [PubMed - as supplied by publisher]
Source: Molecular Biology Reports - September 3, 2020 Category: Molecular Biology Authors: Rashidi G, Rezaeepoor M, Mohammadi C, Solgi G, Najafi R Tags: Mol Biol Rep Source Type: research

Downregulation of miR ‑181b inhibits human colon cancer cell proliferation by targeting CYLD and inhibiting the NF‑κB signaling pathway.
Downregulation of miR‑181b inhibits human colon cancer cell proliferation by targeting CYLD and inhibiting the NF‑κB signaling pathway. Int J Mol Med. 2020 Sep 04;: Authors: Yang X, Sun Y, Zhang Y, Han S Abstract It has been reported that microRNA (miRNA/miR)‑181b plays an important role in regulating cellular proliferation, invasion and apoptosis in various tumors. However, the role of miR‑181b and its molecular mechanisms in colon cancer cells have not yet been elucidated. The present study thus aimed to investigate the mechanisms of miR‑181b targeting cylindromatosis (CYLD) to regulate ...
Source: International Journal of Molecular Medicine - September 3, 2020 Category: Molecular Biology Authors: Yang X, Sun Y, Zhang Y, Han S Tags: Int J Mol Med Source Type: research

Ribosomal protein S3 selectively affects colon cancer growth by modulating the levels of p53 and lactate dehydrogenase.
In this study, we aim at determining the expression levels of RPS3 in a colon cancer cell line Caco-2 compared to a normal colon mucosa cell line NCM-460 and study the effects of targeting this protein by siRNA on cellular behavior. RPS3 was found to be expressed in both cell lines. However, siRNA treatment showed a more protruding effect on Caco-2 cells compared to NCM-460 cells. RPS3 knockdown led to a significant decrease in the proliferation, survival, migration and invasion and an increase in the apoptosis of Caco-2 cells. Western blot analysis demonstrated that these effects correlated with an increase in the level o...
Source: Molecular Biology Reports - August 2, 2020 Category: Molecular Biology Authors: Alam E, Maaliki L, Nasr Z Tags: Mol Biol Rep Source Type: research

Expression of MACC1 protein in gastric cancer and its effect on proliferation and invasion of gastric cancer cells.
CONCLUSION: MACC1 was highly expressed in gastric cancer tissues. The expression of MACC1 was related to the differentiation degree, infiltration depth, lymph node metastasis and staging of gastric cancer. Down-regulation of MACC1 could inhibit the proliferation and invasion of gastric cancer cells. This study provided a certain biological basis for early clinical prediction, diagnosis and treatment of gastric cancer. PMID: 32415936 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Biology - May 18, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

FER1L4/miR-372/E2F1 works as a ceRNA system to regulate the proliferation and cell cycle of glioma cells.
In this study, it was found that the expression of LncRNA FER1L4 is upregulated in high-grade gliomas than in low-grade cases and that a high expression of LncRNA FER1L4 predicts poor prognosis of gliomas. Meanwhile, in vitro study suggests that expression of FER1L4 with SiRNA knockdown obviously suppresses cell cycle and proliferation. It is further demonstrated by experiments that the FER1L4 knockdown suppresses growth of in vivo glioma. Besides, it is found in our study that LncRNA FER1L4 expression is positively correlated with E2F1 mRNA expression. After knockdown of FER1L4 expression, E2F1 expression is significantly...
Source: J Cell Mol Med - March 18, 2019 Category: Molecular Biology Authors: Xia L, Nie D, Wang G, Sun C, Chen G Tags: J Cell Mol Med Source Type: research

Baicalin induced colon cancer cells apoptosis through miR-217/DKK1-mediated inhibition of Wnt signaling pathway.
Abstract To analyze the anti-tumor mechanism of Baicalin in human colon cancer. The MTT assay and colony formation assay demonstrated that Baicalin treatment inhibits the proliferation of DLD1 and HCT-116 cells. The apoptosis rates were induced upon Baicalin treatment and which was determined by FACS. The qPCR and western blot analysis showed that Baicalin promotes expression of DKK1 (Dickkopf), an important antagonist of Wnt signaling pathway, thereby reduces the expression of its downstream protein β-catenin and c-Myc. Reduction of DKK1 expression by siRNA attenuates β-catenin and c-Myc expression. microRNA-21...
Source: Molecular Biology Reports - February 8, 2019 Category: Molecular Biology Authors: Jia Y, Chen L, Guo S, Li Y Tags: Mol Biol Rep Source Type: research

Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19
Conclusion: CAFs promote the stemness and chemoresistance of CRC by transferring exosomal H19. H19 activated the β-catenin pathway via acting as a competing endogenous RNA sponge for miR-141, while miR-141 inhibited the stemness of CRC cells. Our findings indicate that H19 expressed by CAFs of the colorectal tumor stroma contributes to tumor development and chemoresistance.
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Jing Ren, Liang Ding, Dongya Zhang, Guoping Shi, Qianyun Xu, Sunan Shen, Yaping Wang, Tingting Wang, Yayi Hou Tags: Research Paper Source Type: research