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Total 190 results found since Jan 2013.

Abstract 5466: Integrative TCGA analyses identify Basonuclin1 (BNC1) as a key mediator for platinum resistance
Conclusion. Collectively, BNC1 represents an important target for enhancing platinum-sensitivity in ovarian and lung cancer. Targeting BNC1 in platinum-resistant malignancies may improve patient survival.Note: This abstract was not presented at the meeting.Citation Format: Sherry Y. Wu, Justyna Filant, Michael McGuire, Rajesha Rupaimoole, Sunila Pradeep, Anna Unruh, Herbrich Shelley, Cristina Ivan, Ruder Dennis, Cristian Rodriguez-Aguayo, Vasudha Sehgal, Takahito Miyake, Archana Nagaraja, Kshipra Gharpure, Guillermo Armaiz, Rebecca Previs, Gabriel Lopez-Berestein, Prahlad Ram, Keith Baggerly, Anil Sood. Integrative TCGA an...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Wu, S. Y., Filant, J., McGuire, M., Rupaimoole, R., Pradeep, S., Unruh, A., Shelley, H., Ivan, C., Dennis, R., Rodriguez-Aguayo, C., Sehgal, V., Miyake, T., Nagaraja, A., Gharpure, K., Armaiz, G., Previs, R., Lopez-Berestein, G., Ram, P., Baggerly, K., So Tags: Experimental and Molecular Therapeutics Source Type: research

Proteasome inhibitor-resistant cells cause EMT-induction via suppression of E-cadherin by miR-200 and ZEB1.
Abstract Downregulation of E-cadherin (gene: CDH1) plays an important role in epithelial-mesenchymal transition (EMT), which is critical for normal development and disease states. As a result of long-term treatment of endometrial carcinoma Ishikawa cells with epoxomicin (EXM), the cells exhibited the phenotype for EXM-resistance (Ish/EXM cells). Moreover, CDH1 mRNA and its protein were suppressed and EMT was induced in Ish/EXM cells. Ish/EXM cells exhibited drug-resistance to other proteasome inhibitors, MG-132, PSI and PS-341 (Bortezomib). The proteasome inhibitor-resistant cells acquired invasiveness as a result...
Source: International Journal of Oncology - March 4, 2015 Category: Cancer & Oncology Authors: Asakura T, Yamaguchi N, Ohkawa K, Yoshida K Tags: Int J Oncol Source Type: research

DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas
Conclusion: Taken together, whereas DEC2 was found to promote HIF-1α degradation in other types of tumors, our data indicate that DEC2 facilitates HIF-1α stabilization and promotes HIF-1 activation in osteosarcoma. This implies that DEC2 may contribute to the progression and metastasis of human osteosarcoma by sensitizing tumor cells to hypoxia. On the other hand, HIF-1 activation may contribute to the expression of DEC2 in osteosarcoma. This is the first demonstration of a novel DEC2-HIF-1 vicious cycle in osteosarcoma and a tumor-type specific role for DEC2.
Source: Journal of Experimental and Clinical Cancer Research - February 28, 2015 Category: Cancer & Oncology Authors: Tu HuNengbin HeYunsong YangChengqian YinNianli SangQingcheng Yang Source Type: research

Expression of BAF57 in ovarian cancer cells and drug sensitivity
In this study, we investigated BAF57 expression in ovarian cancer cell lines and their sensitivities to cisplatin, doxorubicin, paclitaxel, and 5‐fluorouracil. BAF57 expression was strongly correlated with sensitivities to cisplatin, doxorubicin, and 5‐fluorouracil in 10 ovarian cancer cell lines. Paclitaxel sensitivity was also correlated with BAF57 expression, but without significance. In A2780 ovarian cancer cells, knockdown of BAF57 using specific siRNA increased cell cycle arrest at G1 phase and the sensitivities to these anticancer agents. cDNA microarray analysis of A2780 cells transfected with BAF57 siRNA showe...
Source: Cancer Science - February 25, 2015 Category: Cancer & Oncology Authors: Takahiro Yamaguchi, Tomoko Kurita, Kazuto Nishio, Junichi Tsukada, Toru Hachisuga, Yasuo Morimoto, Yoshiko Iwai, Hiroto Izumi Tags: Original Article Source Type: research

BAD-mediated apoptotic pathway is associated with human cancer development.
Abstract The malignant transformation of normal cells is caused in part by aberrant gene expression disrupting the regulation of cell proliferation, apoptosis, senescence and DNA repair. Evidence suggests that the Bcl-2 antagonist of cell death (BAD)-mediated apoptotic pathway influences cancer chemoresistance. In the present study, we explored the role of the BAD-mediated apoptotic pathway in the development and progression of cancer. Using principal component analysis to derive a numeric score representing pathway expression, we evaluated clinico-genomic datasets (n=427) from corresponding normal, pre-invasive ...
Source: International Journal of Molecular Medicine - February 5, 2015 Category: Molecular Biology Authors: Stickles XB, Marchion DC, Bicaku E, Al Sawah E, Abbasi F, Xiong Y, Bou Zgheib N, Boac BM, Orr BC, Judson PL, Berry A, Hakam A, Wenham RM, Apte SM, Berglund AE, Lancaster JM Tags: Int J Mol Med Source Type: research

OCT4 pseudogene 5 upregulates OCT4 expression to promote proliferation by competing with miR-145 in endometrial carcinoma.
In conclusion, these data indicate that OCT4-pg5 can act as an RNA sponge to protect OCT4 transcripts from being inhibited by miR-145, providing novel insight into the control of OCT4 expression. PMID: 25634023 [PubMed - as supplied by publisher]
Source: Oncology Reports - February 1, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

BAF57 expression of ovarian cancer cells and drug sensitivity
This article is protected by copyright. All rights reserved.
Source: Cancer Science - January 22, 2015 Category: Cancer & Oncology Authors: Takahiro Yamaguchi, Tomoko Kurita, Kazuto Nishio, Junichi Tsukada, Toru Hachisuga, Yasuo Morimoto, Yoshiko Iwai, Hiroto Izumi Tags: Original Article Source Type: research

Aurora kinase A has a significant role as a therapeutic target and clinical biomarker in endometrial cancer.
Abstract Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors and its upregulation induces chromosomal instability, which leads to aneuploidy and cell transformation. To investigate the role of AURKA in endometrial cancer, we evaluated the association of immunohistochemical expression of AURKA with clinicopathological factors. Furthermore, we examined the effects of AURKA inhibition by transfected siRNA in HEC‑1B cells on colony‑forming ability, invasion and migration capacity, and chemosensitivity. Immunohistochemical ...
Source: International Journal of Oncology - January 22, 2015 Category: Cancer & Oncology Authors: Umene K, Yanokura M, Banno K, Irie H, Adachi M, Iida M, Nakamura K, Nogami Y, Masuda K, Kobayashi Y, Tominaga E, Aoki D Tags: Int J Oncol Source Type: research

Title: Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells
Conclusions: Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome. Citation: Whirledge S, Senbanjo LT, Cidlowski JA. 2015. Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect 123:80–87; http://dx.doi.org/10.1289/ehp.1408437 Address correspondence to J.A. Cidlowski, NIH/NIEHS, MD F3-07, P.O. Box 12233, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-1564. E-mail: cidlows1@niehs.nih.gov We thank X. Xu (Integrative Bioinformatic...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Research Article January 2015 Source Type: research

Abstract 1140: Par-4 mediates EMT in response to TGF-{beta} stimulation
In conclusion, our study proposes a novel function of Par-4 as an inductor of EMT in multiple cell lines. Citation Format: François Fabi, Parvesh Chaudhry, Mohan Singh, Eric Asselin. Par-4 mediates EMT in response to TGF-β stimulation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1140. doi:10.1158/1538-7445.AM2014-1140
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Fabi, F., Chaudhry, P., Singh, M., Asselin, E. Tags: Tumor Biology Source Type: research

Abstract 2427: The 5' endonuclease EEPD1 maintains genomic stability by mediating DNA repair pathway choice
EEPD1 (endonuclease/exonuclease/phosphatase family domain-containing 1) is an uncharacterized human protein that we found to be transcriptionally increased upon induction of DNA double strand breaks (DSBs). A549 cells with EEPD1 repressed by siRNA arrested at the G1/S and G2/M transitions and had markedly increased sensitivity to various DSB-inducing agents, such as camptothecin, VP-16, hydroxyurea (HU), and ionizing irradiation (IR). There are two major types of DSB repair, non-homologous end-joining (NHEJ) and homologous recombination (HR), which is essential for replication fork repair. Using the EJ5 NHEJ reporter syste...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Wu, Y., Lee, S.-H., Williamson, E. A., Reinert, B. L., Srinivasan, G., Singh, S., Jaiswal, A.-S., Tornaletti, S., Brantly, A. C., Hromas, R. A. Tags: Molecular and Cellular Biology Source Type: research

Abstract 4066: Glycodelin abolishes PMA-induced migration of MCF-7 breast cancer cells
In conclusion, glycodelin abolished PMA-induced migration in MCF-7 breast cancer cells, while it did not have any effect on the invasion of the cells. Our results suggest that the effect of glycodelin in migration is mediated by reduced activation of PKCδ. Citation Format: Laura C. Hautala, Riitta Koistinen, Hannu Koistinen. Glycodelin abolishes PMA-induced migration of MCF-7 breast cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4066. doi:10.1158/1538-7445.AM2014-4066
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Hautala, L. C., Koistinen, R., Koistinen, H. Tags: Tumor Biology Source Type: research

Abstract 5203: Long non-coding RNA H19 as a novel therapeutic target for pancreatic cancer
Long non-coding RNAs (lncRNAs), non-protein coding transcripts longer than 200 nucleotides, have been recently reported to play important roles in carcinogenesis and cancer metastasis through epigenetic regulation. In the present study, we examined the expression levels and roles of lncRNA in pancreatic cancer to elucidate whether lncRNA could be a novel candidate for pancreatic cancer therapy. First, we injected PANC-1 and PK-45H, pancreatic ductal adenocarcinoma cells into the spleens of NOD/Shi-scid, IL-2Rγnull (NOG) mice, and then established novel cell lines from liver and lung metastatic nodules. Microarray analysis...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Yoshimura, H., Matsuda, Y., Suzuki, T., Naito, Z., Ishiwata, T. Tags: Molecular and Cellular Biology Source Type: research

Abstract 3347: Post-translational modifications of Akt isoform in chemoresistance of endometrial cancer
In conclusion, we are the first to establish a difference in the ubiquitination pattern for the different Akt isoform in the nucleus of endometrial cancer. We are also the first to show a cleavage of Akt isoforms linked to chemosensitive status of endometrial cancer. This study will form the basis for future investigations to determine the role of specific post-translationnal modifications of Akt isoforms in the endometrial cancer. Citation Format: Jérôme Grenier-Naud, Sophie Parent, Eric Asselin. Post-translational modifications of Akt isoform in chemoresistance of endometrial cancer. [abstract]. In: Proceedings of the ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Grenier-Naud, J., Parent, S., Asselin, E. Tags: Molecular and Cellular Biology Source Type: research

151pd * arid1a role in cell cycle regulation and proliferation in mouse and human gynaecological tissues reveals potential therapeutic targets
Conclusions: A core ARID1A-driven transcriptional programme, conserved accross normal tissues and species appears to exist, centred around regulation of genes involved in the G2/M checkpoint. ARID1A loss promotes proliferation in normal tissues, providing important clues as to the mechanisms of ARID1A-driven carcinogenesis. Mitotic kinases emerge as potential therapeutic targets in ARID1A mutant tumours, an observation that is not evident from studies in cancer cell lines.Disclosure: All authors have declared no conflicts of interest.
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Gounaris, I., Brenton, J. Tags: basic science Source Type: research