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Cancer: Endometrial Cancer
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Total 190 results found since Jan 2013.
Apolipoprotein E enhances migration of endometrial cancer cells byactivating the ERK/MMP9 signaling pathway
CONCLUSION: APOE is highly expressed in endometrial cancer tissues to promote cancer cell migration by enhancing ERK phosphorylation and MMP9 expression.PMID:36946043 | PMC:PMC10034534 | DOI:10.12122/j.issn.1673-4254.2023.02.11
Source: Journal of Southern Medical University - March 22, 2023 Category: Universities & Medical Training Authors: C Wu W Cheng Source Type: research
Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior
Oncotarget. 2023 Mar 21;14:219-235. doi: 10.18632/oncotarget.28388.ABSTRACTGlypicans (GPC1-6) are associated with tumorigenic processes and their involvement in neoplastic behavior has been discussed in different cancer types. Here, a cancer-wide GPC expression study, using clinical cancer patient data in The Cancer Genome Atlas, reveals net upregulation of GPC1 and GPC2 in primary solid tumors, whereas GPC3, GPC5 and GPC6 display lowered expression pattern compared to normal tissues. Focusing on GPC1, survival analyses of the clinical cancer patient data reveal statistically significant correlation between high expression...
Source: Oncotarget - March 21, 2023 Category: Cancer & Oncology Authors: Fang Cheng Victor Ch érouvrier Hansson Grigorios Georgolopoulos Katrin Mani Source Type: research
SPOP is essential for DNA replication licensing through maintaining translation of CDT1 and CDC6 in HaCaT cells
In this study, we evaluated the cellular functions of wild-type SPOP in non-cancerous human keratinocyte-derived HaCaT cells expressing wild-type SPOP gene. SPOP knockdown using siRNA in HaCaT cells dramatically reduced cell growth and arrested their cell cycles at G1/S phase. The expression of DNA replication licensing factors CDT1 and CDC6 in HaCaT cells drastically decreased on SPOP knockdown as their translation was inhibited. CDT1 and CDC6 downregulation induced p21 expression without p53 activation. Our results suggest that SPOP is essential for DNA replication licensing in non-cancerous keratinocyte HaCaT cells.PMID...
Source: Biochemical and Biophysical Research communications - February 15, 2023 Category: Biochemistry Authors: Sayoko Sanada Masashi Maekawa Sota Tate Hiroki Nakaoka Yasuhiro Fujisawa Koji Sayama Shigeki Higashiyama Source Type: research
