DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas

Conclusion:
Taken together, whereas DEC2 was found to promote HIF-1α degradation in other types of tumors, our data indicate that DEC2 facilitates HIF-1α stabilization and promotes HIF-1 activation in osteosarcoma. This implies that DEC2 may contribute to the progression and metastasis of human osteosarcoma by sensitizing tumor cells to hypoxia. On the other hand, HIF-1 activation may contribute to the expression of DEC2 in osteosarcoma. This is the first demonstration of a novel DEC2-HIF-1 vicious cycle in osteosarcoma and a tumor-type specific role for DEC2.

Source: Journal of Experimental and Clinical Cancer Research - February 28, 2015 Category: Cancer & Oncology Authors: Tu HuNengbin HeYunsong YangChengqian YinNianli SangQingcheng Yang Source Type: research