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Total 879 results found since Jan 2013.

GSE242255 DNA-PKcs is a key transcriptional and splicing regulator of AR-Vs in advanced prostate cancer
Contributors : Luke Gaughan ; Beth Adamson ; Nicholas BrittainSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the role of DNA-PKcs and RBMX in the regulation of androgen receptor variants we used the CWR22Rv1-AR-EK and CWR22Rv1 cell line in which DNA-PKcs or RBMX has been knocked down by siRNA or DNA-PKcs was inhibited with 1 µM NU7441, NU5455 or AZD7648. We then performed gene expression analysis using data obtained from RNA-seq at two time points (72 hours knockdown and 24 hours drug treatment).
Source: GEO: Gene Expression Omnibus - September 11, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

BOP1 Promotes Prostate Cancer through the DUSP6/MAPK Pathway
CONCLUSIONS: This finding demonstrated that BOP1 promoted CaP progression by regulating the DUSP6/MAPK pathway.PMID:37681336 | DOI:10.56434/j.arch.esp.urol.20237606.54
Source: Archivos Espanoles de Urologia - September 8, 2023 Category: Urology & Nephrology Authors: Xiaoqing Wu Zheng Jing Tianpu Huang Yongsheng Jing Source Type: research

Aberrant PI3K δ splice isoform as a potential biomarker and novel therapeutic target for endocrine cancers
ConclusionIn summary, our study has suggested a promising potential of utilizing PI3Kδ-S (an oncogenic isoform conferring drug resistance and exempt from PTEN regulation) as a prognostic biomarker and drug target in advanced endocrine cancers.
Source: Frontiers in Endocrinology - August 21, 2023 Category: Endocrinology Source Type: research

Androgen receptor knockdown enhances prostate cancer chemosensitivity by down ‐regulating FEN1 through the ERK/ELK1 signalling pathway
ConclusionCollectively, our studies demonstrate that AR knockdown improves the DTX sensitivity of prostate cancer cells by downregulating FEN1 through the ERK/ELK1 signalling pathway.
Source: Cancer Medicine - June 16, 2023 Category: Cancer & Oncology Authors: Weijie Xie, Shulin Li, Huan Guo, Jiawei Zhang, Menjiang Tu, Rui Wang, Bingling Lin, Yuqi Wu, Xiangwei Wang Tags: RESEARCH ARTICLE Source Type: research

Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells
Biochim Biophys Acta Mol Cell Res. 2023 Jun 12:119522. doi: 10.1016/j.bbamcr.2023.119522. Online ahead of print.ABSTRACTProstate cancer (PCa) continues to be one of the most common cancers in men worldwide. The six transmembrane epithelial antigen of the prostate 1 (STEAP1) protein is overexpressed in several types of human tumors, particularly in PCa. Our research group has demonstrated that STEAP1 overexpression is associated with PCa progression and aggressiveness. Therefore, understanding the cellular and molecular mechanisms triggered by STEAP1 overexpression will provide important insights to delineate new strategies...
Source: Biochimica et Biophysica Acta - June 14, 2023 Category: Biochemistry Authors: Sandra M Rocha F átima M Santos S ílvia Socorro Lu ís A Passarinha Cl áudio J Maia Source Type: research