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Cancer: Prostate Cancer
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Total 879 results found since Jan 2013.
Silencing of hepsin and inosine 5-monophosphate dehydrogenase 2 by siRNA reduces prostate cancer cells proliferation
This study aimed to determine the transcript level of PCa-related genes, HPN and IMPDH2, in archived tissues. Their functional roles were further determined using an in vitro model of PCa. Total RNA extraction was done from formalin-fixed paraffin-embedded PCa tissues, and benign prostatic hyperplasia (BPH) tissues acted as the control. Quantitative real-time polymerase chain reaction (qPCR) was performed to measure HPN and IMPDH2 expression. The functional assay was performed in a prostate cancer cell line (DU145) on these two genes by silencing their RNA. We discovered a significantly higher expression of IMPDH2 in PCa s...
Source: Malaysian Journal of Pathology - April 29, 2022 Category: Pathology Authors: N A Wahab H D Dardar R Yunus Z M Zainudin N M Mokhtar Source Type: research
Enhanced autophagy promotes radiosensitivity by mediating Sirt1 downregulation in RM-1 prostate cancer cells
Biochem Biophys Res Commun. 2022 Apr 6;609:84-92. doi: 10.1016/j.bbrc.2022.03.142. Online ahead of print.ABSTRACTAutophagy is a double-edged sword that affects tumor progression by promoting cell survival or death depending on different living contexts. The concrete mechanism by which autophagy modulates the efficacy of radiotherapy for prostate cancer (PC) remains unclear. We exposed RM-1 PC cells to X-ray and explored the role of autophagy in radiation injury. Our results showed increased apoptosis and autophagy levels in RM-1 cells after radiation. Pharmacological inhibition of autophagy by chloroquine significantly mit...
Source: Biochemical and Biophysical Research communications - April 14, 2022 Category: Biochemistry Authors: Kai-Xuan Wang Chen Yan Xu Yang Pei-Yan Zhu Wen-Wen Cui Cong Ye Kan Hu Ting Lan Lin-Yan Huang Wan Wang Ping Ma Su-Hua Qi Bing Gu Lan Luo Source Type: research
Decreased Expression of HN1 Sensitizes Prostate Cancer Cells to Apoptosis Induced by Docetaxel and 2-Methoxyestradiol
CONCLUSION: HN1 is an anti-apoptotic molecule and inhibits Docetaxel and 2-Methoxyestradiol induced apoptosis by targeting Cyclin B1.PMID:35414498
Source: Annals of Clinical and Laboratory Science - April 13, 2022 Category: Laboratory Medicine Authors: Lokman Varisli Source Type: research
