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Total 2013 results found since Jan 2013.

Long noncoding RNA MALAT1 affects the efficacy of radiotherapy for esophageal squamous cell carcinoma by regulating Cks1 expression
ConclusionMALAT1 acted as one positive regulator of the radioresistance of ESCC, at least partly due to its promotion on Cks1 expression. Furthermore, MALAT1‐targeted therapies showed great potential in enhancing the radiotherapeutic effect on ESCC.This article is protected by copyright. All rights reserved.
Source: Journal of Oral Pathology and Medicine - December 8, 2016 Category: Pathology Authors: Zhijun Li, Yang Zhou, Bo Tu, Yu Bu, Aqiu Liu, Conghua Xie Tags: Original Article Source Type: research

The Role of cIAP1 and XIAP in Apoptosis Induced by Tumor Necrosis Factor Alpha in Esophageal Squamous Cell Carcinoma Cells
ConclusioncIAP1 and XIAP play an essential role in the resistance of ESCC cells against apoptosis.
Source: Digestive Diseases and Sciences - January 2, 2017 Category: Gastroenterology Source Type: research

Propofol Suppresses Esophageal Squamous Cell Carcinoma Cell Migration and Invasion by Down-Regulation of Sex-Determining Region Y-box 4 (SOX4).
CONCLUSIONS Propofol inhibits EC9706 cell migration and invasion by down-regulation of SOX4. PMID: 28118321 [PubMed - in process]
Source: Medical Science Monitor - January 25, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Livin enhances chemoresistance in head and neck squamous cell carcinoma.
In conclusion, our results suggest that siRNA-mediated Livin knockdown enhanced the chemosensitivity of the three HNSCC cell lines to cisplatin, 5-FU and docetaxel. Although further investigations are required to support these findings, our results demonstrated that novel therapeutic strategies with combined use of siRNA targeting Livin and chemotherapeutic agents may have applications in the treatment of advanced HNSCC. PMID: 28440463 [PubMed - as supplied by publisher]
Source: Oncology Reports - April 27, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF- κB pathway and reduction of JNK in HNSCC.
IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-κB pathway and reduction of JNK in HNSCC. Oncotarget. 2017 Apr 07;: Authors: Chan LP, Liu C, Chiang FY, Wang LF, Lee KW, Chen WT, Kuo PL, Liang CH Abstract This investigation identifies interleukin 8 (IL-8) as the main inflammatory mediator in head and neck squamous cell carcinoma (HNSCC). The expressions of chemokines of IL-8, IL-1β and IL-6 and the cytokines of tumor necrosis factor-α (TNF-α) were higher in HNSCC patient tissues than in non-cancerous matched tissues (NCMT) whereas the expression of IL-10 was lower. ...
Source: Oncotarget - April 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Nestin expression involves invasiveness of esophageal carcinoma and its downregulation enhances paclitaxel sensitivity to esophageal carcinoma cell apoptosis.
This study indicates that nestin knockdown enhances chemotherapeutic sensitivity of paclitaxel to esophageal carcinoma, and suggests that silencing of nestin could be a valuble therapeutic approach for enhancing drug sensitivity and thereby improving the treatment outcome of esophageal carcinoma patients. PMID: 28548963 [PubMed - as supplied by publisher]
Source: Oncotarget - May 28, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

An in vitro study of the long non ‐coding RNA TUG1 in tongue squamous cell carcinoma
ConclusionThe lncRNA TUG1 may represent a potential oncogene in TSCC.This article is protected by copyright. All rights reserved.
Source: Journal of Oral Pathology and Medicine - May 1, 2017 Category: Pathology Authors: Zhi ‐qiang Li, Rui Zou, Ke‐Xiong Ouyang, Wei‐Jian Ai Tags: Original Article Source Type: research

Effect of TET1 regulating MGMT on chemotherapy resistance of oral squamous cell carcinoma stem cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - June 23, 2017 Category: Biochemistry Authors: Wei Wang, Xin Li, Fan Wang, Xiang ‐Yu Sun Tags: Article Source Type: research

Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.
CONCLUSIONS: These in vitro and in vivo studies suggest that JCAD has a redundant functional role in physiological angiogenesis but serves a pivotal role in pathological angiogenic process after birth. PMID: 28705794 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 13, 2017 Category: Cardiology Authors: Hara T, Monguchi T, Iwamoto N, Akashi M, Mori K, Oshita T, Okano M, Toh R, Irino Y, Shinohara M, Yamashita Y, Shioi G, Furuse M, Ishida T, Hirata KI Tags: Arterioscler Thromb Vasc Biol Source Type: research

An in  vitro study of the long non‐coding RNA TUG1 in tongue squamous cell carcinoma
ConclusionThe lncRNA TUG1 may represent a potential oncogene in TSCC.
Source: Journal of Oral Pathology and Medicine - July 16, 2017 Category: Pathology Authors: Zhi ‐qiang Li, Rui Zou, Ke‐Xiong Ouyang, Wei‐Jian Ai Tags: ORIGINAL ARTICLE Source Type: research

Apolipoprotein E promotes invasion in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) patients generally have a poor prognosis, due to the invasive nature of these tumors. In comparing transcription profiles between OSCC tumors with a more invasive (WPOI 5) versus a less invasive (WPOI 3) pattern of invasion, we identified a total of 97 genes that were overexpressed at least 1.5-fold in the more invasive tumor subtype. The most functionally relevant genes were assessed using in vitro invasion assays with an OSCC cell line (UM-SCC-1). Individual siRNA knockdown of 15 of these 45 genes resulted in significant reductions in tumor cell invasion compared to a non-targeting siRNA control.
Source: American Journal of Pathology - July 24, 2017 Category: Pathology Authors: Sangeeta K. Jayakar, Olivier Loudig, Margaret Brandwein-Gensler, Ryung S. Kim, Thomas J. Ow, Berrin Ustun, Thomas M. Harris, Michael B. Prystowsky, Geoffrey Childs, Jeffrey E. Segall, Thomas J. Belbin Tags: Regular Article Source Type: research

Apolipoprotein E promotes invasion in oral squamous cell carcinoma.
Abstract Oral squamous cell carcinoma (OSCC) patients generally have a poor prognosis, due to the invasive nature of these tumors. In comparing transcription profiles between OSCC tumors with a more invasive (WPOI 5) versus a less invasive (WPOI 3) pattern of invasion, we identified a total of 97 genes that were overexpressed at least 1.5-fold in the more invasive tumor subtype. The most functionally relevant genes were assessed using in vitro invasion assays with an OSCC cell line (UM-SCC-1). Individual siRNA knockdown of 15 of these 45 genes resulted in significant reductions in tumor cell invasion compared to a...
Source: Am J Pathol - July 24, 2017 Category: Pathology Authors: Jayakar SK, Loudig O, Brandwein-Gensler M, Kim RS, Ow TJ, Ustun B, Harris TM, Prystowsky MB, Childs G, Segall JE, Belbin TJ Tags: Am J Pathol Source Type: research

Melanoma antigen A12 regulates cell cycle via tumor suppressor p21 expression.
Authors: Yanagi T, Nagai K, Shimizu H, Matsuzawa SI Abstract Melanoma-associated antigen family A (MAGE-A) is a family of cancer/testis antigens that are expressed in malignant tumors but not in normal tissues other than the testes. MAGE-A12 is a MAGE-A family gene whose tumorigenic function in cancer cells remains unclear. Searches of the Oncomine and NextBio databases revealed that malignant tumors show up-regulation of MAGE-A12 mRNA relative to corresponding normal tissue. In PPC1 primary prostatic carcinoma cells and in HCT116 colorectal cancer cells (wild type and p53-depleted), MAGE-A12 gene knockdown using s...
Source: Oncotarget - August 7, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Targeting of angiopoietin 2-small interfering RNA plasmid/chitosan magnetic nanoparticles in a mouse model of malignant melanoma in vivo.
Authors: Shan XY, Xu TT, Liu ZL, Hu XF, Zhang YD, Guo SZ, Wang B Abstract The aim of the present study was to observe the in vivo targeting characteristic of angiopoietin 2-small interfering RNA (Ang2-siRNA) plasmid/chitosan magnetic nanoparticles in an established nude mouse model of malignant melanoma (MM) under an external magnetic field. The nude mouse MM model was first established, then divided into 3 groups, including the control group, the non-targeting group and the target group, the control group was given normal saline and the non-targeting and targeting groups were administrated particles through the ta...
Source: Oncology Letters - August 9, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA-204-5p inhibits invasion and metastasis of laryngeal squamous cell carcinoma by suppressing forkhead box C1
Conclusions: miR-204-5p is involved in the invasion and metastasis of LSCC. It has a targeted regulatory effect on FOXC1 expression; malignant LSCC behaviors, including cell proliferation, invasion, and metastasis, are suppressed, and tumor growth in vivo is inhibited. This suggests that miR-204-5p may be a target for molecular therapy of LSCC in the future.
Source: Journal of Cancer - September 12, 2017 Category: Cancer & Oncology Authors: Wei Gao, Yongyan Wu, Xiaoling He, Chunming Zhang, Meixia Zhu, Bo Chen, Qingqing Liu, Xukuan Qu, Weiyan Li, Shuxin Wen, Binquan Wang Tags: Research Paper Source Type: research