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Cancer: Bone Cancers

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Total 366 results found since Jan 2013.

Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma.
CONCLUSIONS: The present study identifies a novel signaling involving SYK/c-MYC/MALAT1 as a promising therapeutic target for the treatment of EWS. PMID: 28336564 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - March 23, 2017 Category: Cancer & Oncology Authors: Sun H, Lin DC, Cao Q, Pang B, Gae DD, Lee VK, Lim HJ, Doan N, Said JW, Gery S, Chow M, Mayakonda A, Forscher C, Tyner JW, Koeffler HP Tags: Clin Cancer Res Source Type: research

Wnt/ β‐catenin Signaling Activates Expression of the Bone‐related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - March 28, 2017 Category: Biochemistry Authors: Oscar A. Vega, Claudia M.J. Lucero, Hector F. Araya, Sofia Jerez, Julio C. Tapia, Marcelo Antonelli, Flavio Salazar ‐Onfray, Facundo Las Heras, Roman Thaler, Scott M. Riester, Gary S. Stein, Andre J. van Wijnen, Mario A. Galindo Tags: Article Source Type: research

Long noncoding RNA GAS5 suppresses cell growth and epithelial ‐mesenchymal transition in osteosarcoma by regulating the miR‐221/ARHI pathway
This study explored the potential functions and mechanisms of GAS5 in the tumorigenesis of osteosarcoma. Here, the expression of GAS5, miR‐221 and aplasia Ras homologue member I (ARHI) was determined in osteosarcoma tissues and cells by Real‐time PCR (RT‐qPCR). The underlying mechanism of GAS5 in osteosarcoma growth was analyzed via MTT, Transwell, RT‐qPCR, Western blot, dual‐luciferase reporter assay, RNA immunoprecipitation, and xenograft models after GAS5 overexpression. GAS5 and ARHI levels were significantly reduced, while miR‐221 increased, both in osteosarcoma tissues and cells. Overexpression of GAS5 su...
Source: Journal of Cellular Biochemistry - May 18, 2017 Category: Biochemistry Authors: Kaishan Ye, Shuanke Wang, Haihong Zhang, Hua Han, Bing Ma, Wei Nan Tags: Article Source Type: research

Mir-150 Up-Regulates Glut1 and Increases Glycolysis in Osteosarcoma Cells
Conclusion: These data suggest that miR-150 is involved in regulation of glycolysis in osteosarcoma cells by influencing Glut1 expression. PMID: 28547952 [PubMed - as supplied by publisher]
Source: Asian Pacific Journal of Cancer Prevention - May 28, 2017 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Long Noncoding RNA GAS5 Suppresses Cell Growth and Epithelial –Mesenchymal Transition in Osteosarcoma by Regulating the miR‐221/ARHI Pathway
This study explored the potential functions and mechanisms of GAS5 in the tumorigenesis of osteosarcoma. Here, the expression of GAS5, miR‐221 and aplasia Ras homologue member I (ARHI) was determined in osteosarcoma tissues and cells by Real‐time PCR (RT‐qPCR). The underlying mechanism of GAS5 in osteosarcoma growth was analyzed via MTT, Transwell, RT‐qPCR, Western blot, dual‐luciferase reporter assay, RNA immunoprecipitation, and xenograft models after GAS5 overexpression. GAS5 and ARHI levels were significantly reduced, while miR‐221 increased, both in osteosarcoma tissues and cells. Overexpression of GAS5 su...
Source: Journal of Cellular Biochemistry - June 13, 2017 Category: Biochemistry Authors: Kaishan Ye, Shuanke Wang, Haihong Zhang, Hua Han, Bing Ma, Wei Nan Tags: Article Source Type: research

Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine.
In this report, we show that Ewing sarcoma cells are sensitive to treatment with clofarabine, which is a nucleoside analogue and allosteric inhibitor of RNR. However, clofarabine is a reversible inhibitor of RNR and we found that the effect of clofarabine is limited when using a short (6-hour) drug treatment. Gemcitabine, on the other hand, is an irreversible inhibitor of the RRM1 subunit of RNR and this drug induces apoptosis in Ewing sarcoma cells when used in both 6-hour and longer drug treatments. Treatment of Ewing sarcoma cells with gemcitabine also results in activation of checkpoint kinase 1 (CHK1), which is a crit...
Source: Oncotarget - July 9, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Pneumolysin-induced autophagy contributes to inhibition of osteoblast differentiation through downregulation of Sp1 in human osteosarcoma cells
Conclusion: The results suggest that PLY inhibits osteoblast differentiation by downregulation of Sp1 accompanied by induction of autophagy through ROS-mediated regulation of the AMPK/mTOR pathway. General significance: This study proposes a molecular mechanism for inhibition of osteoblast differentiation in response to PLY.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - July 19, 2017 Category: Biochemistry Source Type: research

SENP1/HIF ‐1α feedback loop modulates hypoxia‐induced cell proliferation, invasion and EMT in human osteosarcoma cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - August 10, 2017 Category: Biochemistry Authors: Xiaowei Wang, Xiaoju Liang, Huan Liang, Bing Wang Tags: Article Source Type: research

Downregulation of BZW2 inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway.
Authors: Cheng DD, Li SJ, Zhu B, Yuan T, Yang QC, Fan CY Abstract Osteosarcoma is the most common malignant bone tumor in adolescents. The function of basic leucine zipper and W2 domains 2 (BZW2) in tumor progression has been reported. However, the role and mechanisms of BZW2 in osteosarcoma remain to be determined. The aim of the present study was to reveal the expression and biological functions of BZW2 in osteosarcoma and to elucidate the proximal mechanisms underlying these functions. The expression of BZW2 in osteosarcoma tissues and cell lines was assessed by qRT-PCR, western blotting and immunohistochemistr...
Source: Oncology Reports - August 11, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

The lncRNA HNF1A ‐AS1 is a negative prognostic factor and promotes tumorigenesis in osteosarcoma
In this study, we detected the HNF1A‐AS1 levels in human osteosarcoma tissues and cell lines by quantitative real‐time polymerase chain reaction (qRT‐PCR), and investigated its role in osteosarcoma by using in vitro assays. Our study showed that HNF1A‐AS1 expression was significantly up‐regulated in human osteosarcoma tissues and cell lines compared with their normal counterparts, and its expression level was positively correlated with the distance metastasis (P = 0.009) and tumour stage (P = 0.019). Moreover, Kaplan–Meier curves with the log‐rank test showed that higher expression of HNF1A‐AS1 conferred a ...
Source: Journal of Cellular and Molecular Medicine - September 1, 2017 Category: Molecular Biology Authors: Lijun Cai, Jinhan Lv, Yinquan Zhang, Junhong Li, Yinong Wang, Huilin Yang Tags: Original Article Source Type: research

The lncRNA HNF1A-AS1 is a negative prognostic factor and promotes tumorigenesis in osteosarcoma.
In this study, we detected the HNF1A-AS1 levels in human osteosarcoma tissues and cell lines by quantitative real-time polymerase chain reaction (qRT-PCR), and investigated its role in osteosarcoma by using in vitro assays. Our study showed that HNF1A-AS1 expression was significantly up-regulated in human osteosarcoma tissues and cell lines compared with their normal counterparts, and its expression level was positively correlated with the distance metastasis (P = 0.009) and tumour stage (P = 0.019). Moreover, Kaplan-Meier curves with the log-rank test showed that higher expression of HNF1A-AS1 conferred a significantly po...
Source: J Cell Mol Med - September 2, 2017 Category: Molecular Biology Authors: Cai L, Lv J, Zhang Y, Li J, Wang Y, Yang H Tags: J Cell Mol Med Source Type: research

i-Fect Deliver Plasmids to the CNS
Important for Gene Expression Studies.I have posted many examples of how our customers usei-FectTM  and otherTransfection Solutions for Gene Manipulation Studies. There are also manypublications.Here we feature how i-Fect was used to delivery plasmids to the CNS: Sara Elramah, Mar ía José López-González, Matthieu Bastide, Florence Dixmérias, Olivier Roca-Lapirot, Anne-Cécile Wielanek-Bachelet, Anne Vital, Thierry Leste-Lasserre, Alexandre Brochard, Marc Landry& Alexandre Favereaux.Spinal miRNA-124 regulates synaptopodin and nociception in an animal model of bone cancer pain. Scientific Reports 7, A...
Source: siRNA and DsiRNA Transfection Efficiency - September 21, 2017 Category: Neuroscience Tags: C iFect Plasmid Transfection Plasmid Vector shRNA plasmids Source Type: news

IL-1 β-induced NF-κB activation down-regulates miR-506 expression to promotes osteosarcoma cell growth through JAG1.
IL-1β-induced NF-κB activation down-regulates miR-506 expression to promotes osteosarcoma cell growth through JAG1. Biomed Pharmacother. 2017 Sep 15;95:1147-1155 Authors: Hu M, Yuan X, Liu Y, Tang S, Miao J, Zhou Q, Chen S Abstract Nowadays, the role of miRNA in tumorigenesis has been largely reported. It was found that miR-506 might be associated with tumorigenesis of various cancers. The present study was aimed to investigate the character of miR-506 and some related factors in human osteosarcoma (OS) carcinogenesis. The expression level of miR-506 was downregulated in OS compared with the normal ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2017 Category: Drugs & Pharmacology Authors: Hu M, Yuan X, Liu Y, Tang S, Miao J, Zhou Q, Chen S Tags: Biomed Pharmacother Source Type: research

SENP1/HIF ‐1α feedback loop modulates hypoxia‐induced cell proliferation, invasion, and EMT in human osteosarcoma cells
Hypoxia is an element intrinsic to most solid‐tumor microenvironments, including that of osteosarcoma (OS), and is associated with resistance to therapy, poor survival, and a malignant phenotype. The purpose of the present study was to investigate the role and underlying mechanism of SUMO‐specific protease 1 (SENP1)/hypoxia‐inducible factor‐1α (HIF‐1α) feedback loop in hypoxic microenvironment of OS. We observed that the expression of SENP1 was remarkably upregulated in OS cells. Additionally, there was a concomitant high expression of HIF‐1α and SENP1 in MG‐63 cells under a hypoxic microenvironment. Inter...
Source: Journal of Cellular Biochemistry - September 27, 2017 Category: Biochemistry Authors: Xiaowei Wang, Xiaoju Liang, Huan Liang, Bing Wang Tags: RESEARCH ARTICLE Source Type: research

miR-34a increases cisplatin sensitivity of osteosarcoma cells in vitro through up-regulation of c-Myc and Bim signal.
CONCLUSIONS: Our data indicated that miR-34a enhanced the sensitivity to cisplatin by upregulation of c-Myc and Bim pathway. PMID: 29060932 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - October 26, 2017 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research