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Cancer: Androgen Independent Prostate Cancer

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Total 29 results found since Jan 2013.

Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgenindependent prostate cancer cells to DNA damage.
Authors: Marampon F, Gravina GL, Ju X, Vetuschi A, Sferra R, Casimiro MC, Pompili S, Festuccia C, Colapietro A, Gaudio E, Di Cesare E, Tombolini V, Pestell RG Abstract Patients with hormone-resistant prostate cancer (PCa) have higher biochemical failure rates following radiation therapy (RT). Cyclin D1 deregulated expression in PCa is associated with a more aggressive disease: however its role in radioresistance has not been determined. Cyclin D1 levels in the androgen-independent PC3 and 22Rv1 PCa cells were stably inhibited by infecting with cyclin D1-shRNA. Tumorigenicity and radiosensitivity were investigated u...
Source: Oncotarget - December 26, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

ErbB-2 signaling plays a critical role in regulating androgen-sensitive and castration-resistant androgen receptor-positive prostate cancer cells.
Abstract While androgen deprivation therapy (ADT) reduces tumor burden, autocrine growth factor loops such as human epidermal growth factor receptor 2 (HER2/ErbB-2/neu) have been proposed to contribute to prostate cancer (PCa) survival and relapse. However, the role of ErbB-2 in regulating androgen-sensitive (AS) and castration-resistant (CR) cell proliferation remains unclear. Here, we determined the role of ErbB-2 in PCa progression and survival under steroid-reduced conditions using two independent PCa cell progression models. In AR-positive androgen-independent (AI) PCa cells that exhibit the CR phenotype, Erb...
Source: Cellular Signalling - August 6, 2015 Category: Cytology Authors: Muniyan S, Chen SJ, Lin FF, Wang Z, Mehta PP, Batra SK, Lin MF Tags: Cell Signal Source Type: research

Abstract 1956: A subset of prostate cancer cells with loss of MST1 expression confers resistance to castration through YAP1-AR interactions
In conclusion, our findings suggest that the Hippo-YAP1-AR signaling axis is one of the key mechanisms for metastatic PC progression and may represent as a promising therapeutic target for patients with the lethal disease.Note: This abstract was not presented at the meeting.Citation Format: Bekir Cinar, Gamze Kuser Abali, Michael Lewis, Colm Morrissey, Isla Garraway. A subset of prostate cancer cells with loss of MST1 expression confers resistance to castration through YAP1-AR interactions. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia,...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Cinar, B., Kuser Abali, G., Lewis, M., Morrissey, C., Garraway, I. Tags: Molecular and Cellular Biology Source Type: research

Abstract 1964: Role of AMP kinase in TRAIL and PPAR{gamma} ligand combination-induced apoptosis and {beta}-catenin cleavage
In this study we found that TRAIL-TZD-induced β-catenin cleavage also involves AMPK. Knockdown of AMPKα showed strong reduction of the cleaved β-catenin product in both cell types. Since TZD is an agonist of PPARγ, we also determined its involvement in this apoptosis pathway. Endogenous expression of PPARγ showed significant differences between DU145 and LNCaP cells, with higher level expression in the DU145 cells. Knockdown of PPARγ in DU145 cells showed a reduction of cleaved caspase 3 levels whereas cleaved caspase 8, 9 and PARP levels were largely unaffected. Luciferase assays with PPARγ-responsive reporter (PPR...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Santha, S., Basu, A., Rana, A., Rana, B. Tags: Molecular and Cellular Biology Source Type: research

TLR9 signaling through NF-κB/RELA and STAT3 promotes tumor-propagating potential of prostate cancer cells.
Authors: Moreira D, Zhang Q, Hossain DM, Nechaev S, Li H, Kowolik CM, D'Apuzzo M, Forman S, Jones J, Pal SK, Kortylewski M Abstract Prostate cancer progression was associated with tumorigenic signaling activated by proinflammatory mediators. However, the etiology of these events remains elusive. Here, we demonstrate that triggering of the innate immune receptor, Toll-like Receptor 9 (TLR9), in androgen-independent prostate cancer cells initiates signaling cascade leading to increased tumor growth and progression. Using limited dilution/serial transplantation experiments, we show that TLR9 is essential for prostate ...
Source: Oncotarget - June 7, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

GSE67457 Expression data from prostate cancer cell lines LNCap (androgen dependent) and DU145 (androgen independent), transfected with Pin1 or control siRNA
Contributors : Akifumi Kushiyama ; Ryuhei Kanaoka ; Tomoichiro AsanoSeries Type : Expression profiling by arrayOrganism : Homo sapiensPin1 inhibiton exerts anti-oncogenic effects on LNCaP and DU145 cells despite the gene regulation patterns by Pin1 were different in both cells.We investigated how Pin1 modulates the gene expressions in the androgen-dependent as well as the androgen-independent prostate cancer cell lines
Source: GEO: Gene Expression Omnibus - April 1, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1.
Authors: Lin HP, Lin CY, Huo C, Hsiao PH, Su LC, Jiang SS, Chan TM, Chang CH, Chen LT, Kung HJ, Wang HD, Chuu CP Abstract Prostate cancer (PCa) patients receiving the androgen ablation therapy ultimately develop recurrent castration-resistant prostate cancer (CRPC) within 1-3 years. Treatment with caffeic acid phenethyl ester (CAPE) suppressed cell survival and proliferation via induction of G1 or G2/M cell cycle arrest in LNCaP 104-R1, DU-145, 22Rv1, and C4-2 CRPC cells. CAPE treatment also inhibited soft agar colony formation and retarded nude mice xenograft growth of LNCaP 104-R1 cells. We identified that CAPE t...
Source: Oncotarget - March 22, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

A precisely substituted benzopyran targets androgen refractory prostate cancer cells through selective modulation of estrogen receptors.
Abstract Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against prostate cancer cells. DL-2-[4-(2-piperidinoethoxy)phenyl]-3-phenyl-2H-1-benzopyran (BP), a SERM designed with benzopyran core, targeted androgen independent prostate cancer (PC-3) cells 14-times more potently than genistein, ~25% more efficiently than tamoxifen and 6.5-times more actively than ICI-182780, without forfeiting significant specificity ...
Source: Toxicology and Applied Pharmacology - February 2, 2015 Category: Toxicology Authors: Kumar R, Verma V, Sharma V, Jain A, Singh V, Sarswat A, Maikhuri JP, Sharma VL, Gupta G Tags: Toxicol Appl Pharmacol Source Type: research

Angiopoietin-like protein 2 induces androgen-independent and malignant behavior in human prostate cancer cells.
Authors: Sato R, Yamasaki M, Hirai K, Matsubara T, Nomura T, Sato F, Mimata H Abstract Angiopoietin-like proteins (ANGPTLs), which comprise 7 members (ANGPTL1-ANGPTL7), structurally resemble angiopoietins. We investigated the roles of ANGPTLs in the acquisition of androgen independence and the malignant behavior of human prostate cancer cells. Expression of ANGPTL messenger RNA (mRNA) and proteins were ascertained using RT-qPCR and western blot analysis in human prostate cancer cell lines. Androgen‑dependent LNCaP and androgen-independent LNCaP/AI cells, respectively, were cultured in fetal bovine and charcoal-s...
Source: Oncology Reports - November 16, 2014 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

A potential regulatory loop between Lin28B:miR‑212 in androgen-independent prostate cancer.
In this study we found that Lin28B co-localized in the nucleus and cytoplasm of the DU145 AIPC. The expression of Lin28B protein positively correlated with the expression of the c-Myc protein in the prostate cancer cell lines and silencing of Lin28B also correlated with a lower expression of the c-Myc protein, but not with the downregulation of c-Myc messenger RNA (mRNA) in the DU145 AIPC cells. We hypothesized that Lin28B regul-ates the expression of c-Myc protein by altering intermediate c-Myc suppressors. Therefore, a microRNA profile of DU145 cells was performed after Lin28B siRNA silencing. Nineteen microRNAs were upr...
Source: International Journal of Oncology - September 9, 2014 Category: Cancer & Oncology Authors: Borrego-Diaz E, Powers BC, Azizov V, Lovell S, Reyes R, Chapman B, Tawfik O, McGregor D, Diaz FJ, Wang X, Veldhuizen PV Tags: Int J Oncol Source Type: research

Androgen deprivation therapy induces androgen receptor-dependent upregulation of Egr1 in prostate cancers.
This study also elucidated the potential mechanism underlying Id1 participation in the progression of prostate cancer. Understanding the key molecular events in the transition from ADPC to AIPC may provide new therapeutic intervention strategies for patients with AIPC. PMID: 25031707 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Xu B, Tang G, Xiao C, Wang L, Yang Q, Sun Y Tags: Int J Clin Exp Pathol Source Type: research

Preparation of Protamine Cationic Nanobubbles and Experimental Study of Their Physical Properties and In Vivo Contrast Enhancement
In this study, we aimed to prepare a novel type of microbubble (MB), protamine cationic nanobubble (NB), to provide a new vector for tumor gene therapy. We prepared cationic NBs with protamine and other lipid components using mechanical oscillation. The protamine cationic NBs had a mean diameter of 521.2 ± 37.57 nm, a zeta potential of +18.5 mV, and a gene-carrying capacity of 15.69 μg androgen receptor (AR) siRNA per 108 NBs. The cationic NBs exhibited superior contrast enhancement for in vivo imaging compared with SonoVue (Bracco, Geneva, Switzerland), and their physical properties did not change significantly a...
Source: Ultrasound in Medicine and Biology - August 12, 2013 Category: Radiology Authors: Hai-Peng Tong, Luo-Fu Wang, Yan-Li Guo, Lang Li, Xiao-Zhou Fan, Jun Ding, Hai-Yun Huang Tags: Original Contributions Source Type: research

The Vav3 oncogene enhances the malignant potential of prostate cancer cells under chronic hypoxia
Conclusions: Our results demonstrate that Vav3 plays a crucial role in prostate cancer growth and malignant behavior, thus revealing a novel potential therapeutic target.
Source: Urologic Oncology: Seminars and Original Investigations - February 11, 2013 Category: Urology & Nephrology Authors: Kenichi Hirai, Takeo Nomura, Mutsushi Yamasaki, Toru Inoue, Takahiro Narimatsu, Ph.D. Chisato Nakada, Ph.D. Yoshiyuki Tsukamoto, Keiko Matsuura, Fuminori Sato, Masatsugu Moriyama, Hiromitsu Mimata Tags: Clinical - Prostate Source Type: research

The Vav3 oncogene enhances the malignant potential of prostate cancer cells under chronic hypoxia.
CONCLUSIONS: Our results demonstrate that Vav3 plays a crucial role in prostate cancer growth and malignant behavior, thus revealing a novel potential therapeutic target. PMID: 23403204 [PubMed - as supplied by publisher]
Source: Urologic Oncology - February 8, 2013 Category: Urology & Nephrology Authors: Hirai K, Nomura T, Yamasaki M, Inoue T, Narimatsu T, Chisato Nakada PD, Yoshiyuki Tsukamoto PD, Matsuura K, Sato F, Moriyama M, Mimata H Tags: Urol Oncol Source Type: research