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Cancer: Androgen Independent Prostate Cancer

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Cancers, Vol. 14, Pages 3074: The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples
Alex Odermatt Prostate cancer (PCa), one of the most common malignancies in men, typically responds to initial treatment, but resistance to therapy often leads to metastases and death. The dehydrogenase/reductase 7 (DHRS7, SDR34C1) is an “orphan” enzyme without known physiological function. DHRS7 was previously found to be decreased in higher-stage PCa, and siRNA-mediated knockdown increased the aggressiveness of LNCaP cells. To further explore the role of DHRS7 in PCa, we analyzed the proteome of LNCaP cells following DHRS7 knockdown to assess potentially altered pathways. Although DHRS7 ...
Source: Cancers - June 23, 2022 Category: Cancer & Oncology Authors: Simon St ücheli Selene Araya Caner Ercan Seraina O. Moser John Gallon Paul Jen ö Salvatore Piscuoglio Luigi Terracciano Alex Odermatt Tags: Article Source Type: research

GSE194248 Human prostate cancer cells (VCaP and AIVCaP): siAR alone (single siRNA) vs. siAR plus OPRK1 (combo-siRNA)
Contributors : Yuki Makino ; Takashi KobayashiSeries Type : Expression profiling by arrayOrganism : Homo sapiensThrough comparative genomics using PDX models of androgen-dependent (AD) and castration-resistant (CR) tumors, we identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistance. Loss of OPRK1 function delays castration-resistance and inhibits castration-resistant growth of prostate cancer cells in culture and in vivo, suggesting OPRK1 as a therapeutic target.To gain insight with regard to biological function of OPRK1 under androgen-depleted condition, we set up two distinct comparisons us...
Source: GEO: Gene Expression Omnibus - April 3, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Activation of TGF- β - SMAD2 signaling by IL-6 drives neuroendocrine differentiation of prostate cancer through p38MAPK
In this study, PCa cells were differentiated with IL-6 in in-vitro to identify novel targets or signaling pathways associated with emergence of NEPC on deprivation of androgens. From the results, we observed an activation of TGF-β signaling pathway is altered through multiple proteins in differentiated LNCaP cells. Hence, we investigated the role of TGF-β axis in PCa cells differentiation. LNCaP cells treated with IL-6 in androgens deprived media release excess TGF-β ligand and this as conditioned media added to cells stimulated NED of PCa cells. TGF-β released by IL-6 stimulated cells activate p38MAPK through SMAD2 th...
Source: Cellular Signalling - January 5, 2022 Category: Cytology Authors: Sirisha Natani K K Sruthi Sakkarai Mohamed Asha Priyanka Khilar Pampana Sandhya Venkata Lakshmi Ramesh Ummanni Source Type: research

Ratio of the expression levels of androgen receptor splice variant 7 to androgen receptor in castration refractory prostate cancer
Oncol Lett. 2021 Dec;22(6):831. doi: 10.3892/ol.2021.13092. Epub 2021 Oct 13.ABSTRACTIn clinical samples, the expression of androgen receptor (AR) and of AR splice variant 7 (AR-V7) is higher in castration-resistant prostate cancer (CRPC) compared with that in hormone-sensitive prostate cancer (PCa). However, there are only a few reports on the ratio of the expression levels of AR-V7 to AR (AR-V7/AR) in prostate tissue. The present study evaluated AR-V7/AR expression in various types of human prostate tissues and CRPC cells. Pretreatment prostate tissue samples from patients with benign prostatic hyperplasia (BPH; n=18), G...
Source: Oncology Letters - October 25, 2021 Category: Cancer & Oncology Authors: Yoshitaka Sekine Hiroshi Nakayama Yoshiyuki Miyazawa Seiji Arai Hidekazu Koike Hiroshi Matsui Yasuhiro Shibata Kazuto Ito Kazuhiro Suzuki Source Type: research

GSE114052 AR regulated transcriptome in prostate cancer cells
Contributors : Dingxiao Zhang ; Qiang Hu ; Dean G TangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIt has been well established that the transcription factor androgen receptor (AR) is obligatory for prostate cancer (PCa) development and progression, but the precise role of the AR in these processes is still unclear. To dissect the role of AR in shaping the transcriptome of prostate cancer cells, RNA-seq data were obtained from AR-positive LNCaP cells treated with various regimens to manipulate endogenous AR signaling. LNCaP cells were cultured in normal medium containing fetal bovi...
Source: GEO: Gene Expression Omnibus - March 4, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Bakuchiol exhibits anti-metastasis activity through NF-κB cross-talk signaling with AR and ERβ in androgen-independent prostate cancer cells PC-3
Publication date: Available online 16 June 2017Source: Journal of Pharmacological SciencesAuthor(s): Lin Miao, Xiaoting Yun, Rui Tao, Yuefei Wang, Xiumei Gao, Guanwei Fan, Yan Zhu, Ting Cai, Zhipeng Zhu, Chunlin YanAbstractAndrogen-independent prostate cancer (PCa) is a developed tumor derived from the local androgen dependent PCa, which often affects elderly men. Psoralea corylifolia L, a traditional Chinese medicine, has been widely used for PCa treatment as an important part of a common prescription, while the mechanism remains unclear. Our study was aimed to investigate the tumor-inhibitory effect of its main component...
Source: Journal of Pharmacological Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

GSE64082 PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells
Contributors : Cordula A Jilg ; Dominica Willmann ; Roland Sch üleSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe aim of this study is to describe expression changes related to the metastatic behavior of PCa cells after siRNA-mediated knockdown of PRK1.
Source: GEO: Gene Expression Omnibus - December 11, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a.
Abstract Most prostate cancers initially respond to androgen deprivation therapy, but then progress from androgen-dependent to androgen-independent prostate cancers. In the present study, a differential cytotoxicity screen of hormone-resistant prostate cancer LNCaP-hr cells and the parental LNCaP-FGC cells against normal MRC5 fibroblast cells, identified a small molecule compound, Aristeromycin (a derivative of 3-deazaneplanocin A (DZNeP)). The molecular target was shown to be S-adenosylhomocysteine hydrolase (AHCY), which catalyzes reversible hydrolysis of S-adenosylhomocysteine (SAH) to adenosine and L-homocyste...
Source: European Journal of Pharmacology - July 10, 2017 Category: Drugs & Pharmacology Authors: Uchiyama N, Tanaka Y, Kawamoto T Tags: Eur J Pharmacol Source Type: research

Bakuchiol exhibits anti-metastasis activity through NF- κB cross-talk signaling with AR and ERβ in androgen-independent prostate cancer cells PC-3
Publication date: Available online 16 June 2017 Source:Journal of Pharmacological Sciences Author(s): Lin Miao, Xiaoting Yun, Rui Tao, Yuefei Wang, Xiumei Gao, Guanwei Fan, Yan Zhu, Ting Cai, Zhipeng Zhu, Chunlin Yan Androgen-independent prostate cancer (PCa) is a developed tumor derived from the local androgen dependent PCa, which often affects elderly men. Psoralea corylifolia L, a traditional Chinese medicine, has been widely used for PCa treatment as an important part of a common prescription, while the mechanism remains unclear. Our study was aimed to investigate the tumor-inhibitory effect of its main component baku...
Source: Journal of Pharmacological Sciences - June 16, 2017 Category: Drugs & Pharmacology Source Type: research

Wnt signaling promotes androgen-independent prostate cancer cell proliferation through up-regulation of the hippo pathway effector YAP.
Abstract Aberrant up-regulation of Wnt/β-catenin signaling is associated with the development and progression of prostate cancer, but the underlying mechanism is unclear. Here we show that in the absence of androgens, the Wnt/β-catenin pathway activates AR-mediated transcription through up-regulation of the Hippo pathway effector Yes-associated protein (YAP). Wnt3a-conditioned medium (Wnt3a-CM) promotes the growth of LNCaP cells and increases AR and YAP protein levels. Moreover, Wnt3a-CM induces the nuclear translocation of YAP and the AR, but not β-catenin, thereby activating the expression of AR- and YAP-depe...
Source: Biochemical and Biophysical Research communications - March 30, 2017 Category: Biochemistry Authors: Seo WI, Park S, Gwak J, Ju BG, Chung JI, Kang PM, Oh S Tags: Biochem Biophys Res Commun Source Type: research

Abstract A16: Different epigenetic mechanisms involved in the regulation of SFRP1 gene in prostate cancer
Among men, prostate cancer (PCa)[1] is the second most common cancer and the fifth cause of death worldwide [2]. Androgens play an important role in the development of the disease. For advanced PCa the standard therapy is androgen depletion. However, after 2 or 3 years a high percentage of patients become resistant to this therapy and castration resistant prostate cancer (CRPC) is developed. There is no successful treatment for CRPC, leading into death [3, 4]. Wingless pathway (WNT) is aberrantly activated in several cancer types and in PCa it is involved in AR activity modulation, promoting cancer development [5]. Secrete...
Source: Cancer Research - January 14, 2016 Category: Cancer & Oncology Authors: Garcia–Tobilla, P., Uribe, O., Rodriguez–Dorantes, M. Tags: Epigenetic Control of Transcription/ Elongation Source Type: research