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Cancer: HER2

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Total 260 results found since Jan 2013.

Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling
Conclusion: We could firstly show that SFRP1 strongly correlates with the triple negative breast cancer subtype and secondly, that SFRP1 might be used as a marker stratifying patients to positively respond to neoadjuvant chemotherapy. The mechanisms by which tumor suppressor SFRP1 influences carcinogenic properties of cancer cells do not rely on Wnt signaling, thereby demonstrating the complexity of tumor associated signaling pathways.
Source: Molecular Cancer - July 17, 2014 Category: Cancer & Oncology Authors: Christof BernemannCarolin HülsewigChristian RuckertSarah SchäferLena BlümelGeorg HempelMartin GötteBurkhard GrevePeter BarthLudwig KieselCornelia Liedtke Source Type: research

Therapeutic Targeting of Integrin {alpha}v{beta}6 in Breast Cancer
Conclusions Targeting αvβ6 with 264RAD alone or in combination with trastuzumab may provide a novel therapy for treating high-risk and trastuzumab-resistant breast cancer patients.
Source: JNCI - June 28, 2014 Category: Cancer & Oncology Authors: Moore, K. M., Thomas, G. J., Duffy, S. W., Warwick, J., Gabe, R., Chou, P., Ellis, I. O., Green, A. R., Haider, S., Brouilette, K., Saha, A., Vallath, S., Bowen, R., Chelala, C., Eccles, D., Tapper, W. J., Thompson, A. M., Quinlan, P., Jordan, L., Gillett Tags: Article Source Type: research

KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer
Background: Kinesin family member 2a (KIF2A), a type of motor protein found in eukaryotic cells, is associated with development and progression of various human cancers. The role of KIF2A during breast cancer tumorigenesis and progression was studied. Methods: Immunohistochemical staining, real time RT-PCR and western blot were used to examine the expression of KIF2A in cancer tissues and adjacent normal tissues from breast cancer patients. Patients' survival in relation to KIF2A expression was estimated using the Kaplan-Meier survival and multivariate analysis. Breast cancer cell line, MDA-MB-231 was used to study the pro...
Source: BMC Cancer - June 21, 2014 Category: Cancer & Oncology Authors: Jianli WangSiqin MaRong MaXun QuWenjun LiuCuixia LvSong ZhaoYunyun Gong Source Type: research

The Epidermal Growth Factor Receptor Critically Regulates Endometrial Function during Early Pregnancy
by Michael J. Large, Margeaux Wetendorf, Rainer B. Lanz, Sean M. Hartig, Chad J. Creighton, Michael A. Mancini, Ertug Kovanci, Kuo-Fen Lee, David W. Threadgill, John P. Lydon, Jae-Wook Jeong, Francesco J. DeMayo Infertility and adverse gynecological outcomes such as preeclampsia and miscarriage represent significant female reproductive health concerns. The spatiotemporal expression of growth factors indicates that they play an important role in pregnancy. The goal of this study is to define the role of the ERBB family of growth factor receptors in endometrial function. Using conditional ablation in mice and siRNA in prima...
Source: PLoS Genetics - June 19, 2014 Category: Genetics & Stem Cells Authors: Michael J. Large et al. Source Type: research

FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation
Conclusions: As a novel Hsp90 inhibitor, FW-04-806 binds to the N-terminal of Hsp90 and inhibits Hsp90/Cdc37 interaction, resulting in the disassociation of Hsp90/Cdc37/client complexes and the degradation of Hsp90 client proteins. FW-04-806 displays promising antitumor activity against breast cancer cells both in vitro and in vivo, especially for HER2-overexpressed breast cancer cells.
Source: Molecular Cancer - June 14, 2014 Category: Cancer & Oncology Authors: Wei HuangMin YeLian-ru ZhangQun-dan WuMin ZhangJian-hua XuWei Zheng Source Type: research

ARTN Mediates Acquired Resistance to Trastuzumab Cell Biology
Previous studies have demonstrated that Artemin (ARTN) functions as a cancer stem cell (CSC) and metastatic factor in mammary carcinoma. Herein, we report that ARTN mediates acquired resistance to trastuzumab in HER2-positive mammary carcinoma cells. Ligands that increase HER2 activity increased ARTN expression in HER2-positive mammary carcinoma cells, whereas trastuzumab inhibited ARTN expression. Forced expression of ARTN decreased the sensitivity of HER2-positive mammary carcinoma cells to trastuzumab both in vitro and in vivo. Conversely, siRNA-mediated depletion of ARTN enhanced trastuzumab efficacy. Cells with acquir...
Source: Journal of Biological Chemistry - June 5, 2014 Category: Chemistry Authors: Ding, K., Banerjee, A., Tan, S., Zhao, J., Zhuang, Q., Li, R., Qian, P., Liu, S., Wu, Z.-S., Lobie, P. E., Zhu, T. Tags: Molecular Bases of Disease Source Type: research

Breast cancer metastasis: demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12
This study was designed to examine the role FOXP3 plays in metastatic breast cancer, with a particular focus on its potential to regulate CXCR4. Human breast cancer samples showed significantly decreased FOXP3 protein expression but an increased number of CXCR4 transcripts. In comparison with normal primary breast epithelial cells, FOXP3 was down‐regulated at both transcript and protein levels in the breast cancer cell lines, MCF‐7 and MDA‐MB‐231. In the invasive MDA‐MB‐231 cells, the remaining FOXP3 was located predominately within the cytoplasm. Following stable FOXP3 over‐expression in MDA‐MB‐231 cells...
Source: The Journal of Pathology - May 28, 2014 Category: Pathology Authors: Stephen Douglass, Annette P Meeson, Dorota Overbeck‐Zubrzycka, John G Brain, Miriam R Bennett, Christopher A Lamb, Thomas WJ Lennard, David Browell, Simi Ali, John A Kirby Tags: Original Article Source Type: research

Erbb2 up‐regulation of ADAM12 expression accelerates skin cancer progression
Solar ultraviolet (UV) radiation can cause severe damage to the skin and is the primary cause of most skin cancer. UV radiation causes DNA damage leading to mutations and also activates the Erbb2/HER2 receptor through indirect mechanisms involving reactive oxygen species. We hypothesized that Erbb2 activation accelerates the malignant progression of UV‐induced skin cancer. Following the induction of benign squamous papillomas by UV exposure of v‐rasHa transgenic Tg.AC mice, mice were treated topically with the Erbb2 inhibitor AG825 and tumor progression monitored. AG825 treatment reduced tumor volume, increased tumor r...
Source: Molecular Carcinogenesis - May 5, 2014 Category: Molecular Biology Authors: Velidi H. Rao, Kristen Vogel, Jodi K. Yanagida, Nitin Marwaha, Amrit Kandel, Carol Trempus, Susan K. Repertinger, Laura A. Hansen Tags: Research Article Source Type: research

A display of pH-sensitive fusogenic GALA peptide facilitates endosomal escape from a Bio-nanocapsule via an endocytic uptake pathway
Conclusion: The genetic fusion of a GALA peptide to the virus-like particle confers the ability of endosomal escape.
Source: Journal of Nanobiotechnology - April 1, 2014 Category: Nanotechnology Authors: Yuya NishimuraKoichi TakedaRyosuke EzawaJun IshiiChiaki OginoAkihiko Kondo Source Type: research

The MAPK Pathway Is a Predominant Regulator of HLA-A Expression in Esophageal and Gastric Cancer.
In conclusion, HLA-A expression is predominantly regulated by the MAPK pathway in gastric and esophageal cancer. PMID: 24244023 [PubMed - as supplied by publisher]
Source: Journal of Immunology - November 15, 2013 Category: Allergy & Immunology Authors: Mimura K, Shiraishi K, Mueller A, Izawa S, Kua LF, So J, Yong WP, Fujii H, Seliger B, Kiessling R, Kono K Tags: J Immunol Source Type: research

The siRNA cocktail targeting VEGF and HER2 inhibition on the proliferation and induced apoptosis of gastric cancer cell.
Abstract The aim of this study was to investigate the inhibitory effect of a siRNA cocktail targeting Vascular endothelial growth factor (VEGF) and Human epidermal growth factor receptor 2 (HER2) on cell proliferation, induced apoptosis and the expression of VEGF and HER2 in human gastric carcinoma cell. The silencing rate of pre-designed siRNAs that targeted VEGF and HER2 was detected by Real-time Quantitative PCR (RT-QPCR) analysis. Furthermore, the best silencing siRNA that targeted VEGF and HER2 was prepared as a cocktail to co-knockdown VEGF and HER2 expression at both mRNA and protein levels which were detec...
Source: Molecular and Cellular Biochemistry - October 26, 2013 Category: Biochemistry Authors: Liu K, Chen H, You Q, Shi H, Wang Z Tags: Mol Cell Biochem Source Type: research

Heregulin Induces Resistance to Lapatinib‐mediated Growth Inhibition of HER2‐Amplified Cancer Cells
This article is protected by copyright. All rights reserved.
Source: Cancer Science - September 24, 2013 Category: Cancer & Oncology Authors: Yuji Sato, Masakazu Yashiro, Nobuyuki Takakura Tags: Original Article Source Type: research

Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery.
Abstract Efficient and targeted cellular delivery of small interfering RNAs (siRNAs) and antisense oligonucleotides (AONs) is a major challenge facing oligonucleotide-based therapeutics. The majority of current delivery strategies employ either conjugated ligands or oligonucleotide encapsulation within delivery vehicles to facilitate cellular uptake. Chemical modification of the oligonucleotides (ONs) can improve potency and duration of activity, usually as a result of improved nuclease resistance. Here we take advantage of innovations in both polymeric delivery vehicles and ON stabilization to achieve receptor-me...
Source: Biomaterials - August 7, 2013 Category: Materials Science Authors: Chan DP, Deleavey GF, Owen SC, Damha MJ, Shoichet MS Tags: Biomaterials Source Type: research

RON confers lapatinib resistance in HER2-positive breast cancer cells
Highlights: Abstract: Lapatinib-resistance is a major problem for HER2-positive breast cancer treatment. SK-BR-3-LR, a lapatinib-resistant cell clone, was established from HER2-positive SK-BR-3 breast cancer cells following chronic exposure to lapatinib. The PI3K/AKT signaling pathway was demonstrated to be resistant to HER2 inhibition in SK-BR-3-LR cells. However, both small-molecular Recepteur d’Origine Nantais (RON) inhibitors and RON-targeted small interfering RNA (siRNA) effectively restored lapatinib sensitivity in these cells by inhibiting PI3K/AKT activation. Our results demonstrate for the first time the importa...
Source: Cancer Letters - July 15, 2013 Category: Cancer & Oncology Authors: Quanren Wang, Haitian Quan, Jie Zhao, Chengying Xie, Lei Wang, Liguang Lou Tags: Research Articles Source Type: research

Inhibition of vacuolar H+ ATPase enhances sensitivity to tamoxifen via up-regulation of CHOP in breast cancer cells.
Abstract Resistance of estrogen receptor-positive breast cancer cells to tamoxifen represents a major barrier to the successful treatment of breast cancer. In the present study, we found that vacuolar H+ ATPase (vATPase) inhibitors, bafilomycin A1 and concanamycin A, sensitize tamoxifen-induced cell death. siRNA targeting ATP6V0C, a 16-kDa hydrophobic proteolipid subunit of vATPase that plays a central role in H+ transport, markedly increased cell death induced by tamoxifen. Interestingly, bafilomycin A1 induced up-regulation of DR4/DR5 and CHOP. Knock-down of CHOP by siRNA suppressed the cell death induced by baf...
Source: Biochemical and Biophysical Research communications - July 6, 2013 Category: Biochemistry Authors: Jin HO, Lee YH, Kim HA, Kim EK, Noh WC, Kim YS, Hwang CS, Kim JI, Chang YH, Hong SI, Hong YJ, Park IC, Lee JK Tags: Biochem Biophys Res Commun Source Type: research