Filtered By:
Cancer: Gastric (Stomach) Cancer

This page shows you your search results in order of relevance. This is page number 19.

Order by Relevance | Date

Total 1410 results found since Jan 2013.

Silencing the YB‐1 Gene Inhibits Cell Migration in Gastric Cancer In Vitro
ABSTRACT The Y‐Box‐Binding Protein‐1 (YB‐1) is known to regulate the processes of transcription, translation, cellular response to drug treatment and viral infection as well as DNA repair among others. As gastric cancer is a common cancer with a high incidence in countries in Asia, we evaluated the association of YB‐1 with the malignant potential of gastric cancer cells in vitro. YB‐1 mRNA expression levels were first determined by real‐time RT‐PCR in two adherent gastric cancer cell lines (viz., MKN7 and NUGC3 gastric cancer cells) and a normal GES‐1 gastric epithelial cell line. Poorly differentiated NU...
Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - April 24, 2013 Category: Molecular Biology Authors: Tian Tian Guo, Ying Nan Yu, George Wai Cheong Yip, Ken Matsumoto, Boon Huat Bay Tags: Full Length Article Source Type: research

SERPINA3K induces apoptosis in human colorectal cancer cells via activating the Fas/FasL/caspase‐8 signaling pathway
This article is protected by copyright. All rights reserved.
Source: FEBS Journal - April 25, 2013 Category: Research Authors: Yachao Yao, Lei Li, Xuan Huang, Xiaoqiong Gu, Zumin Xu, Yang Zhang, Lijun Huang, Shuai Li, Zhiyu Dai, Cen Li, Ti Zhou, Weibin Cai, Zhonghan Yang, Guoquan Gao, Xia Yang Tags: Original Article Source Type: research

Silencing the YB-1 Gene Inhibits Cell Migration in Gastric Cancer In Vitro.
Abstract The Y-Box-Binding Protein-1 (YB-1) is known to regulate the processes of transcription, translation, cellular response to drug treatment and viral infection as well as DNA repair among others. As gastric cancer is a common cancer with a high incidence in countries in Asia, we evaluated the association of YB-1 with the malignant potential of gastric cancer cells in vitro. YB-1 mRNA expression levels were first determined by real-time RT-PCR in two adherent gastric cancer cell lines (viz., MKN7 and NUGC3 gastric cancer cells) and a normal GES-1 gastric epithelial cell line. Poorly differentiated NUGC3 gastr...
Source: Anatomical Record - May 24, 2013 Category: Anatomy Authors: Guo TT, Yu YN, Cheong Yip GW, Matsumoto K, Bay BH Tags: Anat Rec (Hoboken) Source Type: research

Trefoil factor 3 peptide regulates migration via a Twist-dependent pathway in SGC7901 cell.
In this study, we investigated the role of Twist protein in TFF3-induced migration of SGC7901 cells. While Twist was activated by TFF3, siRNA-mediated knockdown of Twist abolished TFF3-induced cell migration. Furthermore, the migration related marker CK-8 as well as ZO-1 and MMP-9 was also regulated by TFF3 via a Twist-dependent mechanism. Our study suggests that Twist, as an important potential downstream effector, plays a key role in TFF3-modulated metastasis in gastric cancer and can be a promising therapeutic target against intestinal-type gastric cancer. PMID: 23845905 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - July 8, 2013 Category: Biochemistry Authors: Zheng Q, Gao J, Li H, Guo W, Mao Q, Gao E, Zhu YQ Tags: Biochem Biophys Res Commun Source Type: research

Epigallocatechin-3-gallate regulates the expression of Kruppel-like factor 4 through myocyte enhancer factor 2A.
Abstract Epigallocatechin-3-gallate (EGCG), a powerful antioxidant and free ion scavenger found in green tea, exhibits inhibitory effects on different stages of tumorigenesis. Within gastric cancer cells, the transcription factor Kruppel-like factor 4 (KLF4) is downregulated, and it is possible that EGCG exerts its anti-tumorigenic function through modulation of KLF4 expression. In order to examine the effects of EGCG on KLF4 in a gastric tumor model, we treated the gastric cancer cell line NCI-N87 with EGCG. We found that EGCG treatment results in increased expression of KLF4 and alters expression of the KLF4 tar...
Source: Cell Stress and Chaperones - July 25, 2013 Category: Cytology Authors: Ma Y, Shi Y, Li W, Sun A, Zang P, Zhang P Tags: Cell Stress Chaperones Source Type: research

Helicobacter pylori down‐regulates expression of human β‐defensin 1 in the gastric mucosa in a type IV secretion dependent fashion
Summary Helicobacter pylori establishes a chronic lifelong infection in the human gastric mucosa, which may lead to peptic ulcer disease or gastric adenocarcinoma. The human beta‐defensins (hβDs) are antimicrobial peptides, hβD1 being constitutively expressed in the human stomach. We hypothesised that H. pylori may persist, in part, by downregulating gastric hβD1 expression. We measured hβD1 and hβD2 expression in vivo in relation to the presence, density and severity of H. pylori infection, investigated differential effects of H. pylori virulence factors, and studied underlying signalling mechanisms in vitro. Signi...
Source: Cellular Microbiology - July 29, 2013 Category: Microbiology Authors: S.R. Patel, K. Smith, D.P. Letley, K.W. Cook, A.A. Memon, R.J.M. Ingram, E. Staples, S. Backert, A.M. Zaitoun, J.C. Atherton, K. Robinson Tags: Research Article Source Type: research

Expression of neuroepithelial transforming gene 1 is enhanced in oesophageal cancer and mediates an invasive tumour cell phenotype
Conclusions: As found in other malignancies, NET1 expression is elevated in OAC and its pre-malignant phenotype, Barrett's oesophagus. NET1 promotes OAC cell invasion and proliferation and it mediates LPA-induced OAC cell migration.
Source: Journal of Experimental and Clinical Cancer Research - August 14, 2013 Category: Cancer & Oncology Authors: Conor LahiffEoin CotterRory CaseyPeter DoranGraham PidgeonJohn ReynoldsPadraic MacMathunaDavid Murray Source Type: research

Heregulin Induces Resistance to Lapatinib‐mediated Growth Inhibition of HER2‐Amplified Cancer Cells
This article is protected by copyright. All rights reserved.
Source: Cancer Science - September 24, 2013 Category: Cancer & Oncology Authors: Yuji Sato, Masakazu Yashiro, Nobuyuki Takakura Tags: Original Article Source Type: research

Genistein Induces G2/M Arrest in Gastric Cancer Cells by Increasing the Tumor Suppressor PTEN Expression.
Abstract Genistein, a major isoflavone found in soybeans, exhibits anticarcinogenic properties. The inhibitory effect of genistein on cell proliferation is associated with G2/M cell cycle arrest and inhibition of cdc2 activities. Here we assessed the role of PTEN in regulation of genistein-mediated G2/M cell cycle arrest in the gastric cancer cell lines (SGC-7901 and BGC-823). After 24 h following treatment, genistein induced a concentration-dependent accumulation of cells in the G2/M phase of the cell cycle. The sustained G2/M arrest by genistein in SGC-7901 and BGC-823 cells is associated with increased phospho...
Source: Nutrition and Cancer - September 20, 2013 Category: Cancer & Oncology Authors: Liu YL, Zhang GQ, Yang Y, Zhang CY, Fu RX, Yang YM Tags: Nutr Cancer Source Type: research

JMJD2B promotes epithelial-mesenchymal transition by cooperating with β-catenin and enhances gastric cancer metastasis.
CONCLUSION: The data reveals a novel function of JMJD2B in promoting EMT and GC invasion and metastasis, implicating JMJD2B as a potential target for reversing EMT and intervention of the progression of GC. PMID: 24077348 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - September 27, 2013 Category: Cancer & Oncology Authors: Zhao L, Li W, Zang W, Liu Z, Xu X, Yu H, Yang Q, Jia J Tags: Clin Cancer Res Source Type: research

Vitamin D Analog EB1089 Induces Apoptosis in a Subpopulation of SGC-7901 Gastric Cancer Cells Through a Mitochondrial-Dependent Apoptotic Pathway.
Abstract Gastric cancer is the second leading cause of cancer death worldwide. Cancer stem-like side population (SP) cells may be important factors that hinder efficacy of chemopreventative and chemotherapeutic approaches in gastric cancer. EB1089 is an antitumor agent that has been used in many cancers; however, no reports to date have determined the effects of EB1089 in gastric cancer. In our study, SP and main population (MP) cells were isolated from 4 gastric cancer cell lines in different stages of differentiation by flow cytometry (FCM) and confirmed by reverse transcription polymerase chain reaction (RT-PCR...
Source: Nutrition and Cancer - October 7, 2013 Category: Cancer & Oncology Authors: Wang W, Zhao CH, Zhang N, Wang J Tags: Nutr Cancer Source Type: research

Involvement of Nuclear JAK2 Signaling in AG490‐Induced Apoptosis of Gastric Cancer Cells
ABSTRACT Although JAK2 inhibitors can result in antitumor activity against various tumors, some tumors have showed insensitivity or resistance to the inhibitors. To investigate the possible mechanisms underlying responses of gastric cancer (GC) cells to AG490, a specific JAK2 inhibitor, human GC cell lines SGC7901 and AGS were used. AG490 did not significantly induce apoptosis in SGC7901 cells, but it did in AGS cells. Interestingly, in SGC7901 cells, AG490 led to increased nuclear translocation of total JAK2 proteins, accompanied with initial inactivation but later reactivation of JAK2. However, in AGS cells, AG490 led to...
Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - October 22, 2013 Category: Molecular Biology Authors: Cuijuan Qian, Jiji Wang, Jun Yao, Lan Wang, Meng Xue, Weili Liu, Jianmin Si Tags: Full Length Article Source Type: research

Involvement of Nuclear JAK2 Signaling in AG490-Induced Apoptosis of Gastric Cancer Cells.
Abstract Although JAK2 inhibitors can result in antitumor activity against various tumors, some tumors have showed insensitivity or resistance to the inhibitors. To investigate the possible mechanisms underlying responses of gastric cancer (GC) cells to AG490, a specific JAK2 inhibitor, human GC cell lines SGC7901 and AGS were used. AG490 did not significantly induce apoptosis in SGC7901 cells, but it did in AGS cells. Interestingly, in SGC7901 cells, AG490 led to increased nuclear translocation of total JAK2 proteins, accompanied with initial inactivation but later reactivation of JAK2. However, in AGS cells, AG4...
Source: Anatomical Record - October 23, 2013 Category: Anatomy Authors: Qian C, Wang J, Yao J, Wang L, Xue M, Liu W, Si J Tags: Anat Rec (Hoboken) Source Type: research

The MAPK Pathway Is a Predominant Regulator of HLA-A Expression in Esophageal and Gastric Cancer.
In conclusion, HLA-A expression is predominantly regulated by the MAPK pathway in gastric and esophageal cancer. PMID: 24244023 [PubMed - as supplied by publisher]
Source: Journal of Immunology - November 15, 2013 Category: Allergy & Immunology Authors: Mimura K, Shiraishi K, Mueller A, Izawa S, Kua LF, So J, Yong WP, Fujii H, Seliger B, Kiessling R, Kono K Tags: J Immunol Source Type: research

Overexpression of GNAO1 correlates with poor prognosis in patients with gastric cancer and plays a role in gastric cancer cell proliferation and apoptosis.
Abstract Guanine nucleotide-binding protein (G protein), alpha activating activity polypeptide O (GNAO1) encodes an alpha subunit of the heterotrimeric guanine nucleotide-binding proteins (Gαo), which plays a significant role in the development of various types of cancer, including breast cancer and hepatocellular carcinoma. However, its role in gastric cancer (GC) has not yet been elucidated. In the current study, the expression of Gαo was analyzed by immunohistochemistry in paraffin-embedded tissue sections from 70 patients with GC and its cellular role was examined by small interfering RNA (siRNA)-mediated...
Source: International Journal of Molecular Medicine - December 20, 2013 Category: Molecular Biology Authors: Liu Z, Zhang J, Wu L, Liu J, Zhang M Tags: Int J Mol Med Source Type: research