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Therapy: Stem Cell Therapy
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Total 56328 results found since Jan 2013.
Shrinking the Battlefield in Cancer Therapy: Nanotechnology Against Cancer Stem Cells
In conclusion, nanotechnology presents a novel, powerful tool in the fight against cancer, particularly in targeting the elusive and treatment-resistant CSCs. This comprehensive review delves into the intricacies of nanotherapy, explicitly targeting cancer stem cells, their markers, and associated signaling pathways.PMID:37729956 | DOI:10.1016/j.ejps.2023.106586
Source: European Journal of Pharmaceutical Sciences - September 20, 2023 Category: Drugs & Pharmacology Authors: Queenie Fernandes Lubna Therachiyil Abdul Q Khan Takwa Bedhiafi Hesham M Korashy Ajaz A Bhat Shahab Uddin Source Type: research
Early T-Cell Precursor Leukemia: A High-Risk Subtype of Acute Lymphoblastic Leukemia, Single Center Experience in Jordan
CONCLUSION: ETP-ALL/LBL represents a high-risk disease subtype of adult ALL. Novel treatment strategies are needed to improve treatment outcomes in this patient's population.PMID:37730482 | DOI:10.1016/j.clml.2023.08.007
Source: Clinical Lymphoma and Myeloma - September 20, 2023 Category: Cancer & Oncology Authors: Khalid Halahleh Isra Muradi Mohammad Zakaria Khalil Lina Halahleh Maher Sughayer Nazmi Kamal Iyad Sultan Kamal Alrabi Source Type: research
Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage polarization and chondrocyte apoptosis
In this study, we found that TUC339 was lower in the research group than in the control group and it was negatively correlated with IL-6, IL-8 and TNF-α. Prognosis TUC339 was lower in patients with recurrent OA than in those without recurrence, and ROC analysis manifested that TUC339 had a better predictive value for recurrence of OA. Phenotypic identification revealed elevated expression of CD29 and CD44 in BMSCs and TSG101, CD63 and CD81 in BMSCs-exosome (BMSCs-exo), with a stem cell versus exosome phenotype. Finally, animal experiments improved significantly in joint injury in the BMSCs-exo and TUC339-overexpression ve...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xun Shen Jian Qin Zijian Wei Feng Liu Source Type: research
Human CD34 < sup > + < /sup > -derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8 < sup > + < /sup > T cell and NK cell responses in vitro and in vivo
In this study, we aimed to dissect the phenotypic identity of these non-DCs and their potential immune modulatory functions on the potency of cDCs and pDCs in stimulating tumor-reactive CD8+ T and NK cell responses, in order to obtain rationale for clinical translation of our DC-complete vaccine. The non-DC compartment was heterogeneous and comprised of myeloid progenitors and (immature) granulocyte- and monocyte-like cells. Importantly, non-DCs potentiated toll-like receptor-induced DC maturation, as reflected by increased expression of co-stimulatory molecules and enhanced cDC-derived IL-12 and pDC-derived IFN-α product...
Source: Cellular and Molecular Life Sciences : CMLS - September 20, 2023 Category: Cytology Authors: Jesper van Eck van der Sluijs Diede van Ens Jolanda Brummelman Daan Heister Aastha Sareen Lisa Truijen Dorette S van Ingen Schenau Mirjam H M Heemskerk Marieke Griffioen Michel G D Kester Nicolaas P M Schaap Joop H Jansen Anniek B van der Waart Harry Dols Source Type: research
A cell size threshold triggers commitment to stomatal fate in < em > Arabidopsis < /em >
Sci Adv. 2023 Sep 22;9(38):eadf3497. doi: 10.1126/sciadv.adf3497. Epub 2023 Sep 20.ABSTRACTHow flexible developmental programs integrate information from internal and external factors to modulate stem cell behavior is a fundamental question in developmental biology. Cells of the Arabidopsis stomatal lineage modify the balance of stem cell proliferation and differentiation to adjust the size and cell type composition of mature leaves. Here, we report that meristemoids, one type of stomatal lineage stem cell, trigger the transition from asymmetric self-renewing divisions to commitment and terminal differentiation by crossing...
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Yan Gong Renee Dale Hannah F Fung Gabriel O Amador Margot E Smit Dominique C Bergmann Source Type: research
Industry updates from the field of stem cell research and regenerative medicine in July 2023
Regen Med. 2023 Sep 20. doi: 10.2217/rme-2023-0177. Online ahead of print.ABSTRACTLatest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in July 2023.PMID:37727975 | DOI:10.2217/rme-2023-0177
Source: Regenerative Medicine - September 20, 2023 Category: Genetics & Stem Cells Authors: Dusko Ilic Mirjana Liovic Source Type: research
Quality of life and financial toxicity of hematopoietic stem cell transplant recipients in COVID-19
CONCLUSION: the quality of life of the sample was low; there is a correlation between quality of life and financial toxicity, although not significant. The higher the financial toxicity, the lower the quality of life.PMID:37729248 | DOI:10.1590/1518-8345.6688.3995
Source: Revista Latino-Americana de Enfermagem - September 20, 2023 Category: Nursing Authors: Nat ália Naome Oshiro Luciana de Alcantara Nogueira Yasmin Hiorrana Dos Santos Paulo Ricardo Bittencourt Guimar ães Luciana Puchalski Kalinke Source Type: research
Industry updates from the field of stem cell research and regenerative medicine in July 2023
Regen Med. 2023 Sep 20. doi: 10.2217/rme-2023-0177. Online ahead of print.ABSTRACTLatest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in July 2023.PMID:37727975 | DOI:10.2217/rme-2023-0177
Source: Regenerative Medicine - September 20, 2023 Category: Genetics & Stem Cells Authors: Dusko Ilic Mirjana Liovic Source Type: research
Impact of previous anthracycline therapy in patients with acute myeloid leukemia receiving venetoclax
In this study, prior chemotherapy/allo-SCT and cytogenetic risk were associated with VEN treatment outcomes.PMID:37728705 | DOI:10.1007/s12185-023-03664-1
Source: International Journal of Hematology - September 20, 2023 Category: Hematology Authors: Ryujiro Hara Shinichiro Machida Norisato Hashimoto Daisuke Ogiya Hidetsugu Kawai Shohei Kawakami Sawako Shiraiwa Makoto Onizuka Yoshiaki Ogawa Hiroshi Kawada Kiyoshi Ando Source Type: research
Updated guidelines for chronic active Epstein-Barr virus disease
Int J Hematol. 2023 Sep 20. doi: 10.1007/s12185-023-03660-5. Online ahead of print.ABSTRACTChronic active Epstein-Barr virus disease (CAEBV), formerly named chronic active Epstein-Barr virus infection, is characterized by systemic inflammation and clonal proliferation of Epstein-Barr virus (EBV)-infected T or NK cells. As CAEBV is a potentially life-threatening illness, appropriate diagnosis and therapeutic interventions are necessary for favorable clinical outcomes. Substantial evidence regarding the pathogenesis and treatment of CAEBV has been accumulated since previous guidelines for the diagnosis of CAEBV were proposed...
Source: International Journal of Hematology - September 20, 2023 Category: Hematology Authors: Jun-Ichi Kawada Yoshinori Ito Koichi Ohshima Masaki Yamada Shinsuke Kataoka Hideki Muramatsu Akihisa Sawada Taizo Wada Ken-Ichi Imadome Ayako Arai Keiji Iwatsuki Shouichi Ohga Hiroshi Kimura Committee for Guidelines for the Management of Chronic Active EB Source Type: research
Polysaccharide-Based Composite Hydrogel with Hierarchical Microstructure for Enhanced Vascularization and Skull Regeneration
Biomacromolecules. 2023 Sep 20. doi: 10.1021/acs.biomac.3c00655. Online ahead of print.ABSTRACTCritical-size skull defects caused by trauma, infection, and tumor resection raise great demands for efficient bone substitutes. Herein, a hybrid cross-linked hierarchical microporous hydrogel scaffold (PHCLS) was successfully assembled by a multistep procedure, which involved (i) the preparation of poly(lactic-co-glycolic)/nanohydroxyapatite (PLGA-HAP) porous microspheres, (ii) embedding the spheres in a solution of dopamine-modified hyaluronic acid and collagen I (Col I) and cross-linking via dopamine polyphenols binding to (i)...
Source: Biomacromolecules - September 20, 2023 Category: Biochemistry Authors: Gonggong Lu Xiang Li Peilei Wang Xing Li Yuxiang Wang Jiayi Zhu Alfredo Ronca Ugo D'Amora Wenke Liu Xuhui Hui Source Type: research
Single-nucleus transcriptomic mapping uncovers targets for traumatic brain injury
In this study, we meticulously mapped the transcriptome atlas of murine SVZ and its responses to mTBI at the single-cell level. We observed cell-specific gene expression changes following mTBI and unveiled diverse cell-to-cell interaction networks that influence a wide array of cellular processes. Moreover, we reported novel neurogenesis lineage trajectories and related key transcription factors, which we subsequently validated through loss-of-function experiments. Specifically, we validated the role of Tcf7l1, a cell cycle gene regulator, in promoting neural stem cell differentiation towards the neuronal lineage after mTB...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Qiuyun Yang Lingxuan Zhang Manrui Li Yang Xu Xiaogang Chen Ruixuan Yuan Xiaofeng Ou Min He Miao Liao Lin Zhang Hao Dai Meili Lv Xiaoqi Xie Weibo Liang Xiameng Chen Source Type: research
The Pathogenesis of COVID-19-Related Taste Disorder and Treatments
J Dent Res. 2023 Sep 20:220345231182926. doi: 10.1177/00220345231182926. Online ahead of print.ABSTRACTCOVID-19, mainly manifested as acute respiratory distress syndrome, has afflicted millions of people worldwide since 2019. Taste dysfunction is a common early-stage symptom of COVID-19 infection that burdens patients for weeks or even permanently in some cases. Owing to its subjectivity and complexity, the mechanism of taste disorder is poorly studied. Previous studies have reported that the COVID-19 entry receptors are highly expressed in taste buds, thereby intensifying the cytocidal effect. Taste receptor cells are vul...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: J Wang R Liu H Ma W Zhang Source Type: research
Investigation of conditioned medium properties obtained from human umbilical cord mesenchymal stem/stromal cells preconditioned with dimethyloxalylglycine in a correlation with ultrastructural changes
Microsc Res Tech. 2023 Sep 20. doi: 10.1002/jemt.24420. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) hold significant therapeutic value due to their regeneration abilities, migration capacity, and immunosuppressive and immunomodulatory properties. These cells secrete soluble and insoluble factors, and this complex secretome contributes to their therapeutic effect. Furthermore, stimulation of cells by various external stimuli lead to secretome modifications that can increase the therapeutic efficacy. So, this study examined the effect of dimethyloxalylglycine (DMOG), a hypoxia-mimetic agent, on secret...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Hanife Nurdan Olcar Basak Isildar Serbay Ozkan Merve Ercin Selda Gezginci-Oktayoglu Meral Koyuturk Source Type: research
