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Therapy: Stem Cell Therapy
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Temporal pattern of Fos and Jun families expression after mitogenic stimulation with FGF-2 in rat neural stem cells and fibroblasts
Braz J Med Biol Res. 2023 Sep 8;56:e12546. doi: 10.1590/1414-431X2023e12546. eCollection 2023.ABSTRACTIntense stimulation of most living cells triggers the activation of immediate early genes, such as Fos and Jun families. These genes are important in cellular and biochemical processes, such as mitosis and cell death. The present study focused on determining the temporal expression pattern of Fos and Jun families in fibroblasts and neural stem cells of cerebellum, hippocampus, and subventricular zone (SVZ) of rats of different ages at 0, 0.5, 1, 3, and 6 h after stimulation with fibroblast growth factor (FGF)-2. In neonate...
Source: Braz J Med Biol Res - September 13, 2023 Category: Research Authors: A C Mosini P C Mazzonetto M L Cali ó C Pompeu F H Massinhani T K E Nakamura J M Pires C S Silva M A Porcionatto L E Mello Source Type: research
Cernunnos deficiency: Further delineation in 5 Egyptian patients
In conclusion, Cernunnos deficiency can have a wide range of clinical features. The characteristic immune profile including a decrease in recent thymic emigrants and naive T cells, markedly elevated memory T cells together with normal to high IgM, and a decrease in IgG and IgA. This immune profile is highly suggestive of Cernunnos deficiency in T-B-NK + SCID patients especially surviving for older ages.PMID:37703920 | DOI:10.1016/j.ejmg.2023.104840
Source: European Journal of Medical Genetics - September 13, 2023 Category: Genetics & Stem Cells Authors: Rabab El Hawary Safa Meshaal Sohilla Lotfy Dalia Abd Elaziz Radwa Alkady Alia Eldash Aya Erfan Engy Chohayeb Mai Saad Rania Darwish Jeannette Boutros Nermeen Galal Aisha Elmarsafy Source Type: research
Temporal pattern of Fos and Jun families expression after mitogenic stimulation with FGF-2 in rat neural stem cells and fibroblasts
Braz J Med Biol Res. 2023 Sep 8;56:e12546. doi: 10.1590/1414-431X2023e12546. eCollection 2023.ABSTRACTIntense stimulation of most living cells triggers the activation of immediate early genes, such as Fos and Jun families. These genes are important in cellular and biochemical processes, such as mitosis and cell death. The present study focused on determining the temporal expression pattern of Fos and Jun families in fibroblasts and neural stem cells of cerebellum, hippocampus, and subventricular zone (SVZ) of rats of different ages at 0, 0.5, 1, 3, and 6 h after stimulation with fibroblast growth factor (FGF)-2. In neonate...
Source: Braz J Med Biol Res - September 13, 2023 Category: Research Authors: A C Mosini P C Mazzonetto M L Cali ó C Pompeu F H Massinhani T K E Nakamura J M Pires C S Silva M A Porcionatto L E Mello Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain
Cell Metab. 2023 Sep 7:S1550-4131(23)00304-2. doi: 10.1016/j.cmet.2023.08.009. Online ahead of print.ABSTRACTWeight regain after weight loss is a major challenge in the treatment of obesity. Immune cells adapt to fluctuating nutritional stress, but their roles in regulating weight regain remain unclear. Here, we identify a stem cell-like CD7+ monocyte subpopulation accumulating in the bone marrow (BM) of mice and humans that experienced dieting-induced weight loss. Adoptive transfer of CD7+ monocytes suppresses weight regain, whereas inducible depletion of CD7+ monocytes accelerates it. These cells, accumulating metabolic ...
Source: Cell Metabolism - September 13, 2023 Category: Cytology Authors: Hai-Yan Zhou Xu Feng Li-Wen Wang Rui Zhou Heng Sun Xin Chen Ren-Bin Lu Yan Huang Qi Guo Xiang-Hang Luo Source Type: research
Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases
Regen Med. 2023 Sep 13. doi: 10.2217/rme-2023-0089. Online ahead of print.ABSTRACTResearch has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential the...
Source: Regenerative Medicine - September 13, 2023 Category: Genetics & Stem Cells Authors: Wesley Harrisson Bouche Djatche Huimin Zhu Wenlei Ma Yue Li Ziang Li Hong Zhao Zhizhen Liu Hua Qiao Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
TR β Agonism Induces Tumor Suppression and Enhances Drug Efficacy in Anaplastic Thyroid Cancer in Female Mice
Endocrinology. 2023 Sep 13:bqad135. doi: 10.1210/endocr/bqad135. Online ahead of print.ABSTRACTThyroid hormone receptor beta (TRβ) is a recognized tumor suppressor in numerous solid cancers. The molecular signaling of TRβ has been elucidated in several cancer types through re-expression models. Remarkably, the potential impact of selective activation of endogenous TRβ on tumor progression remains largely unexplored. We used cell-based and in vivo assays to evaluate the effects of the TRβ agonist Sobetirome (GC-1) on a particularly aggressive and dedifferentiated cancer, anaplastic thyroid cancer (ATC). Here we report t...
Source: Endocrinology - September 13, 2023 Category: Endocrinology Authors: Noelle E Gillis Lauren M Cozzens Emily R Wilson Noah M Smith Jennifer A Tomczak Eric L Bolf Frances E Carr Source Type: research
Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases
Regen Med. 2023 Sep 13. doi: 10.2217/rme-2023-0089. Online ahead of print.ABSTRACTResearch has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential the...
Source: Regenerative Medicine - September 13, 2023 Category: Genetics & Stem Cells Authors: Wesley Harrisson Bouche Djatche Huimin Zhu Wenlei Ma Yue Li Ziang Li Hong Zhao Zhizhen Liu Hua Qiao Source Type: research
Temporal pattern of Fos and Jun families expression after mitogenic stimulation with FGF-2 in rat neural stem cells and fibroblasts
Braz J Med Biol Res. 2023 Sep 8;56:e12546. doi: 10.1590/1414-431X2023e12546. eCollection 2023.ABSTRACTIntense stimulation of most living cells triggers the activation of immediate early genes, such as Fos and Jun families. These genes are important in cellular and biochemical processes, such as mitosis and cell death. The present study focused on determining the temporal expression pattern of Fos and Jun families in fibroblasts and neural stem cells of cerebellum, hippocampus, and subventricular zone (SVZ) of rats of different ages at 0, 0.5, 1, 3, and 6 h after stimulation with fibroblast growth factor (FGF)-2. In neonate...
Source: Braz J Med Biol Res - September 13, 2023 Category: Research Authors: A C Mosini P C Mazzonetto M L Cali ó C Pompeu F H Massinhani T K E Nakamura J M Pires C S Silva M A Porcionatto L E Mello Source Type: research
TR β Agonism Induces Tumor Suppression and Enhances Drug Efficacy in Anaplastic Thyroid Cancer in Female Mice
Endocrinology. 2023 Sep 13:bqad135. doi: 10.1210/endocr/bqad135. Online ahead of print.ABSTRACTThyroid hormone receptor beta (TRβ) is a recognized tumor suppressor in numerous solid cancers. The molecular signaling of TRβ has been elucidated in several cancer types through re-expression models. Remarkably, the potential impact of selective activation of endogenous TRβ on tumor progression remains largely unexplored. We used cell-based and in vivo assays to evaluate the effects of the TRβ agonist Sobetirome (GC-1) on a particularly aggressive and dedifferentiated cancer, anaplastic thyroid cancer (ATC). Here we report t...
Source: Endocrinology - September 13, 2023 Category: Endocrinology Authors: Noelle E Gillis Lauren M Cozzens Emily R Wilson Noah M Smith Jennifer A Tomczak Eric L Bolf Frances E Carr Source Type: research
Umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models
This study revealed the anti-inflammatory properties of UCMSC-CM and its regulatory effect on glial activation in the treatment of neuroinflammation in ALS, providing strong evidence for the clinical application of UCMSC-CM.PMID:37704056 | DOI:10.1016/j.brainresbull.2023.110760
Source: Brain Research Bulletin - September 13, 2023 Category: Neurology Authors: Jingshu Tang Yuying Kang Yujun Zhou Qiuyu Chen Jiaqi Lan Xuebin Liu Ying Peng Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
