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A Novel Mutation of < em > MSH2 < /em > Gene in a Patient with Lynch Syndrome Presenting with Thirteen Metachronous Malignancies
J Clin Med. 2023 Aug 24;12(17):5502. doi: 10.3390/jcm12175502.ABSTRACTLynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), accounts for 2-3% of all colorectal cancers. This autosomal dominant disorder is associated with a predisposition to endometrial, stomach, small bowel, pancreatic, biliary tract, ovary, urinary tract, brain, and skin tumors. Lynch syndrome is caused by the mutation of the MLH1, MSH2 (EPCAM), MSH6, and PMS2 genes. In this article, a case study of a 70-year-old female patient with Lynch syndrome is presented. Over a span of 30 years, the patient underwent multiple surgica...
Source: Clinical Colorectal Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Ugne Silinskaite Edita Gavelien ė Rokas Stulpinas Ramunas Janavicius Tomas Poskus Source Type: research
Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study
Brain Behav Immun. 2023 Sep 7;114:299-310. doi: 10.1016/j.bbi.2023.09.004. Online ahead of print.ABSTRACTPatients characterized by stress-related disorders such as depression display elevated circulating concentrations of pro-inflammatory cytokines and a hyperactive HPA axis. Psychedelics are demonstrating promising results in treatment of such disorders, however the mechanisms of their therapeutic effects are still unknown. To date the evidence of acute and persisting effects of psychedelics on immune functioning, HPA axis activity in response to stress, and associated psychological outcomes is preliminary. To address thi...
Source: Brain, Behavior, and Immunity - September 9, 2023 Category: Neurology Authors: N L Mason A Szabo K P C Kuypers P A Mallaroni R de la Torre Fornell J T Reckweg D H Y Tse N R P W Hutten A Feilding J G Ramaekers Source Type: research
Differentiation of lung and breast cancer brain metastases: Comparison of texture analysis and deep convolutional neural networks
CONCLUSION: CNNs achieved superior diagnostic performance in differentiating brain metastases from lung and breast malignancies than texture-based image features. Differentiation using 3D volumes as input exhibited a higher success rate than 2D sagittal images.PMID:37688435 | DOI:10.1002/jcu.23558
Source: Clinical Genitourinary Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Mehmet Ali Gultekin Abdusselim Adil Peker Ayse Betul Oktay Haci Mehmet Turk Dilek Hacer Cesme Abdallah T M Shbair Temel Fatih Yilmaz Ahmet Kaya Ayse Irem Yasin Mesut Seker Alpaslan Mayadagli Alpay Alkan Source Type: research
Machine-Learning-Aided Prediction of Brain Metastases Development in Non-Small-Cell Lung Cancers
CONCLUSION: Analysis of the importance of input features suggests that the models are learning the relevant relationships between clinical features/development of BM. A higher number of samples is to be prioritized to improve performance. Employed prospectively at initial diagnosis, such models can help select high-risk subgroups for surveillance brain MRI.PMID:37689579 | DOI:10.1016/j.cllc.2023.08.002
Source: Clinical Lung Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Giovanni Vison à Lisa M Spiller Sophia Hahn Elke Hattingen Thomas J Vogl Gabriele Schweikert Katrin Bankov Melanie Demes Henning Reis Peter Wild Pia S Zeiner Fabian Acker Martin Sebastian Katharina J Wenger Source Type: research
Differentiation of lung and breast cancer brain metastases: Comparison of texture analysis and deep convolutional neural networks
CONCLUSION: CNNs achieved superior diagnostic performance in differentiating brain metastases from lung and breast malignancies than texture-based image features. Differentiation using 3D volumes as input exhibited a higher success rate than 2D sagittal images.PMID:37688435 | DOI:10.1002/jcu.23558
Source: Clinical Lung Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Mehmet Ali Gultekin Abdusselim Adil Peker Ayse Betul Oktay Haci Mehmet Turk Dilek Hacer Cesme Abdallah T M Shbair Temel Fatih Yilmaz Ahmet Kaya Ayse Irem Yasin Mesut Seker Alpaslan Mayadagli Alpay Alkan Source Type: research
Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study
Brain Behav Immun. 2023 Sep 7;114:299-310. doi: 10.1016/j.bbi.2023.09.004. Online ahead of print.ABSTRACTPatients characterized by stress-related disorders such as depression display elevated circulating concentrations of pro-inflammatory cytokines and a hyperactive HPA axis. Psychedelics are demonstrating promising results in treatment of such disorders, however the mechanisms of their therapeutic effects are still unknown. To date the evidence of acute and persisting effects of psychedelics on immune functioning, HPA axis activity in response to stress, and associated psychological outcomes is preliminary. To address thi...
Source: Brain, Behavior, and Immunity - September 9, 2023 Category: Neurology Authors: N L Mason A Szabo K P C Kuypers P A Mallaroni R de la Torre Fornell J T Reckweg D H Y Tse N R P W Hutten A Feilding J G Ramaekers Source Type: research
Radiation dose to sleep-relevant brain structures linked to impaired sleep quality in primary brain tumor patients
Acta Oncol. 2023 Sep 9:1-6. doi: 10.1080/0284186X.2023.2249219. Online ahead of print.NO ABSTRACTPMID:37688522 | DOI:10.1080/0284186X.2023.2249219
Source: Acta Oncologica - September 9, 2023 Category: Cancer & Oncology Authors: Ali Amidi Lene Haldbo-Classen Jesper F Kallehauge Lisa M Wu Robert Zachariae Yasmin Lassen-Ramshad Slavka Lukacova Morten H øyer Source Type: research
Advancements and emerging trends in brain tumor classification using MRI: a systematic review
AbstractBrain tumor (BT) classification plays a crucial role in the diagnosis and treatment of BTs using Magnetic Resonance Imaging (MRI) scans. This systematic review aims to analyze and summarize the existing literature on BT classification using MRI, focusing on the advancements, techniques, and trends in this field. A comprehensive search strategy was employed to identify relevant articles published between 2020 and 2023. The selected articles were analyzed based on their pre-processing techniques, feature extraction methods, segmentation approaches, and classification algorithms. The review highlights the strengths an...
Source: Network Modeling Analysis in Health Informatics and Bioinformatics - September 9, 2023 Category: Bioinformatics Source Type: research
A meta-analysis for the efficacy and safety of icotinib combined with radiotherapy in treating brain metastases of non-small cell lung cancer
CONCLUSION: Icotinib combined with radiotherapy can significantly short-term and long-term efficacy of NSCLC patients with brain metastases but not increase adverse reactions.PMID:37682155 | DOI:10.1097/MD.0000000000034572
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Bo Zhang Source Type: research
Clinicopathologic study of stage I adenosquamous carcinoma of the lung
CONCLUSIONS: Early-stage adenosquamous carcinoma of the lung is a histological type associated with severe prognosis and postoperative recurrence, often in distant sites, in approximately one-third of cases. High serum carcinoembryonic antigen levels and vascular invasion might be risk factors of recurrence.PMID:37681230 | DOI:10.1093/jjco/hyad122
Source: Clinical Lung Cancer - September 8, 2023 Category: Cancer & Oncology Authors: Yoshinori Handa Takuhiro Ikeda Hideaki Hanaki Yoshihiro Miyata Hidenori Mukaida Morihito Okada Source Type: research
Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
Mol Med Rep. 2023 Oct;28(4):198. doi: 10.3892/mmr.2023.13085. Epub 2023 Sep 8.ABSTRACTIn recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effec...
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Qi Nie Wenqing Chen Tianmei Zhang Shangrong Ye Zhongyu Ren Peng Zhang Jian Wen Source Type: research
Updated Austrian treatment algorithm for metastatic triple-negative breast cancer
Wien Klin Wochenschr. 2023 Sep 8. doi: 10.1007/s00508-023-02254-9. Online ahead of print.ABSTRACTApproximately 15% of newly diagnosed breast cancer patients have neither hormone receptors expression nor HER2 overexpression and/or HER2/neu gene amplification. This subtype of breast cancer is known as Triple Negative Breast Cancer (TNBC), and carries a significantly elevated risk of local and distant recurrence. In comparison with other breast cancer subtypes, there is a higher rate of visceral and brain metastases. The majority of metastases of TNBC are diagnosed within three years after initial breast cancer diagnosis. Whi...
Source: Wiener Klinische Wochenschrift - September 8, 2023 Category: General Medicine Authors: Rupert Bartsch Gabriel Rinnerthaler Edgar Petru Daniel Egle Michael Gnant Marija Balic Thamer Sliwa Christian Singer Source Type: research
Clinicopathologic study of stage I adenosquamous carcinoma of the lung
CONCLUSIONS: Early-stage adenosquamous carcinoma of the lung is a histological type associated with severe prognosis and postoperative recurrence, often in distant sites, in approximately one-third of cases. High serum carcinoembryonic antigen levels and vascular invasion might be risk factors of recurrence.PMID:37681230 | DOI:10.1093/jjco/hyad122
Source: Clinical Lung Cancer - September 8, 2023 Category: Cancer & Oncology Authors: Yoshinori Handa Takuhiro Ikeda Hideaki Hanaki Yoshihiro Miyata Hidenori Mukaida Morihito Okada Source Type: research
