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Total 19833 results found since Jan 2013.

Biochemical, Serological and Immunological Tests for Diagnosis of Coronavirus Disease 2019 (COVID-19) Patients: A Comprehensive Systematic Review and Meta-analysis
CONCLUSION: The results show lymphopenia, elevated ESR level, elevated CRP level, elevated serum amyloid-A, elevated TNFα, elevated procalcitonin level, elevated interleukin-6 level, reduced CD3, reduced CD4, elevated BNP, elevated LDH, reduced albumin, reduced pre-albumin, and elevated Ddimer levels as the most common findings at the time of admission.PMID:37646320 | DOI:10.2174/1871526523666230228144910
Source: Infectious Disorders Drug Targets - August 30, 2023 Category: Infectious Diseases Authors: Milad Azami Amirreza Jamshidbeigi Hadi Esmaeili Gouvarchin Ghaleh Reza Ranjbar Source Type: research

Utility of growth differentiation factor-15 as a predictor of cardiovascular surgery outcomes: Current research and future directions
This study acknowledges that the relationship between patient outcomes and elevated GDF-15 levels is not limited to CVDs or cardiac surgery but can be associated with variable diseases, including diabetes and cancer. Moreover, the normal range of GDF-15 is not well defined. Given its promise for improving patient care and outcomes in cardiovascular surgery, future research should explore the potential of GDF-15 as a biomarker for postoperative outcomes and target therapeutic intervention.PMID:37648079 | DOI:10.1016/j.jjcc.2023.08.013
Source: Journal of Cardiology - August 30, 2023 Category: Cardiology Authors: Ikuko Shibasaki Naoyuki Otani Motoshi Ouchi Taira Fukuda Taiki Matsuoka Shotaro Hirota Shohei Yokoyama Yuta Kanazawa Takashi Kato Riha Shimizu Masahiro Tezuka Yusuke Takei Go Tsuchiya Shunsuke Saito Taisuke Konishi Koji Ogata Shigeru Toyoda Hirotsugu Fuku Source Type: research

Proteomic and metabolomic analyses illustrate the mechanisms of expression of the O 6 -methylguanine-DNA methyltransferase gene in glioblastoma
CONCLUSION: This study provides novel mechanisms to understand methylation in GBM and identifies some biomarkers for the prognosis of two different GBM types, MGMT promoter unmethylated or methylated GBM, by using metabolomics and proteomics analyses.PMID:37641495 | DOI:10.1111/cns.14415
Source: CNS Neuroscience and Therapeutics - August 29, 2023 Category: Neuroscience Authors: Xi Chen Jinli Sun Yukui Li Weichao Jiang Zhangyu Li Jianyao Mao Liwei Zhou Sifang Chen Guowei Tan Source Type: research

Microbial production of docosahexaenoic acid (DHA): biosynthetic pathways, physical parameter optimization, and health benefits
Arch Microbiol. 2023 Aug 29;205(9):321. doi: 10.1007/s00203-023-03666-x.ABSTRACTOmega-3 fatty acids, including docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and α-linolenic acid (ALA), are essential polyunsaturated fatty acids with diverse health benefits. The limited conversion of dietary DHA necessitates its consumption as food supplements. Omega-3 fatty acids possess anti-arrhythmic and anti-inflammatory capabilities, contributing to cardiovascular health. Additionally, DHA consumption is linked to improved vision, brain, and memory development. Furthermore, omega-3 fatty acids offer protection against vario...
Source: Archives of Microbiology - August 29, 2023 Category: Microbiology Authors: Naaz Abbas Sana Riaz Sania Mazhar Ramsha Essa Maria Maryam Yasar Saleem Quratulain Syed Ishrat Perveen Bakhtawar Bukhari Saira Ashfaq Syed Hussain Imam Abidi Source Type: research

Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain
In this study, we aimed to test the hypothesis that WBI induces endothelial senescence, contributing to chronic disruption of the blood-brain barrier (BBB) and microvascular rarefaction. To accomplish this, we utilized transgenic p16-3MR mice, which enable the identification and selective elimination of senescent cells. These mice were subjected to a clinically relevant fractionated WBI protocol (5 Gy twice weekly for 4 weeks), and cranial windows were applied to both WBI-treated and control mice. Quantitative assessment of BBB permeability and capillary density was performed using two-photon microscopy at the 6-month post...
Source: Cancer Control - August 29, 2023 Category: Cancer & Oncology Authors: Rafal Gulej Ádám Nyúl-Tóth Chetan Ahire Jordan DelFavero Priya Balasubramanian Tamas Kiss Stefano Tarantini Zoltan Benyo Pal Pacher Boglarka Csik Andriy Yabluchanskiy Peter Mukli Anna Kuan-Celarier Istv án A Krizbai Judith Campisi William E Sonntag A Source Type: research

Targeting EZH2 regulates the biological characteristics of glioma stem cells via the Notch1 pathway
Exp Brain Res. 2023 Aug 29. doi: 10.1007/s00221-023-06693-8. Online ahead of print.ABSTRACTGlioma is the most common malignant brain tumor, and its behavior is closely related to the presence of glioma stem cells (GSCs). We found that the enhancer of zeste homolog 2 (EZH2) is highly expressed in glioma and that its expression is correlated with the prognosis of glioblastoma multiforme (GBM) in two databases: The Cancer Genome Atlas and the Chinese Glioma Genome Atlas. Additionally, EZH2 is known to regulate the stemness-associated gene expression, proliferation, and invasion ability of GSCs, which may be achieved through t...
Source: Brain Research - August 29, 2023 Category: Neurology Authors: Guozheng Zhao Zhitong Deng Xuetao Li Hao Wang Guangliang Chen Ming Feng Youxin Zhou Source Type: research

Targeting EZH2 regulates the biological characteristics of glioma stem cells via the Notch1 pathway
Exp Brain Res. 2023 Aug 29. doi: 10.1007/s00221-023-06693-8. Online ahead of print.ABSTRACTGlioma is the most common malignant brain tumor, and its behavior is closely related to the presence of glioma stem cells (GSCs). We found that the enhancer of zeste homolog 2 (EZH2) is highly expressed in glioma and that its expression is correlated with the prognosis of glioblastoma multiforme (GBM) in two databases: The Cancer Genome Atlas and the Chinese Glioma Genome Atlas. Additionally, EZH2 is known to regulate the stemness-associated gene expression, proliferation, and invasion ability of GSCs, which may be achieved through t...
Source: Experimental Brain Research - August 29, 2023 Category: Neuroscience Authors: Guozheng Zhao Zhitong Deng Xuetao Li Hao Wang Guangliang Chen Ming Feng Youxin Zhou Source Type: research

Head-to-head comparison of 68 GaGa-DOTA.SA.FAPi with 18 FF-FDG PET/CT in radioiodine-resistant follicular-cell derived thyroid cancers
CONCLUSION: The study results demonstrate the superior performance of [68Ga]Ga-DOTA.SA.FAPi compared to [18F]F-FDG PET/CT in detecting lymph nodal, liver, bowel, and brain metastases in patients with RAI-R-FCTC. These findings highlight the potential of [68Ga]Ga-DOTA.SA.FAPi as a theranostic tool that can complement the benefits of [18F]F-FDG PET/CT in the imaging of RAI-R-FCTC.PMID:37642703 | DOI:10.1007/s00259-023-06404-z
Source: Molecular Medicine - August 29, 2023 Category: Molecular Biology Authors: Sanjana Ballal Madhav P Yadav Frank Roesch Swayamjeet Satapathy Euy Sung Moon Marcel Martin Nicky Wakade Parvind Sheokand Madhavi Tripathi Kunal R Chandekar Shipra Agarwal Ranjit Kumar Sahoo Sameer Rastogi Chandrasekhar Bal Source Type: research

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