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IL-27-induced, MSC-derived Exosomes Promote MMP3 Expression Through the miR-206/L3MBTL4 Axis in Synovial Fibroblasts
CONCLUSIONS: IL-27 can induce the expression of miR-206 in MSCs, and miR-206 can be transported into FLS through MSC-EVs to promote FLS migration and MMP3 expression and aggravate articular cartilage damage. Patients with RA who have a high IL-27 expression may not be suitable to receive treatment with MSCs, and clinicians can use MSCs that knock down or delete IL-27R to treat RA patients who have a high IL-27 expression.PMID:37678876
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Lihui Ma Yueli Liu Fenghuang Xu Ruiming Shen Min Wang Yunfei Zhang Chang Liu Guifu Zheng Source Type: research
Misdiagnosis of a Dissecting Aneurysm as a Cerebral Aneurysm: A Preoperative Case Report
CONCLUSION: Cerebral aneurysms typically involve larger arteries with rare possibilities of stenosis. Moreover, the cerebral artery is relatively small, making it challenging for Brain Computed Tomography Angiography (CTA) to distinguish true and false lumen within blood vessels. The diagnosis of dissecting aneurysms is difficult and often susceptible to clinical misdiagnosis.PMID:37678872
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Xiaohong Guo Yi Wu Junkang Fang Source Type: research
IL-27-induced, MSC-derived Exosomes Promote MMP3 Expression Through the miR-206/L3MBTL4 Axis in Synovial Fibroblasts
CONCLUSIONS: IL-27 can induce the expression of miR-206 in MSCs, and miR-206 can be transported into FLS through MSC-EVs to promote FLS migration and MMP3 expression and aggravate articular cartilage damage. Patients with RA who have a high IL-27 expression may not be suitable to receive treatment with MSCs, and clinicians can use MSCs that knock down or delete IL-27R to treat RA patients who have a high IL-27 expression.PMID:37678876
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Lihui Ma Yueli Liu Fenghuang Xu Ruiming Shen Min Wang Yunfei Zhang Chang Liu Guifu Zheng Source Type: research
Misdiagnosis of a Dissecting Aneurysm as a Cerebral Aneurysm: A Preoperative Case Report
CONCLUSION: Cerebral aneurysms typically involve larger arteries with rare possibilities of stenosis. Moreover, the cerebral artery is relatively small, making it challenging for Brain Computed Tomography Angiography (CTA) to distinguish true and false lumen within blood vessels. The diagnosis of dissecting aneurysms is difficult and often susceptible to clinical misdiagnosis.PMID:37678872
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Xiaohong Guo Yi Wu Junkang Fang Source Type: research
IL-27-induced, MSC-derived Exosomes Promote MMP3 Expression Through the miR-206/L3MBTL4 Axis in Synovial Fibroblasts
CONCLUSIONS: IL-27 can induce the expression of miR-206 in MSCs, and miR-206 can be transported into FLS through MSC-EVs to promote FLS migration and MMP3 expression and aggravate articular cartilage damage. Patients with RA who have a high IL-27 expression may not be suitable to receive treatment with MSCs, and clinicians can use MSCs that knock down or delete IL-27R to treat RA patients who have a high IL-27 expression.PMID:37678876
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Lihui Ma Yueli Liu Fenghuang Xu Ruiming Shen Min Wang Yunfei Zhang Chang Liu Guifu Zheng Source Type: research
Misdiagnosis of a Dissecting Aneurysm as a Cerebral Aneurysm: A Preoperative Case Report
CONCLUSION: Cerebral aneurysms typically involve larger arteries with rare possibilities of stenosis. Moreover, the cerebral artery is relatively small, making it challenging for Brain Computed Tomography Angiography (CTA) to distinguish true and false lumen within blood vessels. The diagnosis of dissecting aneurysms is difficult and often susceptible to clinical misdiagnosis.PMID:37678872
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Xiaohong Guo Yi Wu Junkang Fang Source Type: research
2022 Cannon Lecture: An ode to signal transduction - how the growth hormone pathway revealed insight into height, malignancy and obesity
Am J Physiol Endocrinol Metab. 2023 Sep 6. doi: 10.1152/ajpendo.00265.2023. Online ahead of print.ABSTRACTWalter Cannon was a highly regarded American neurologist and physiologist with extremely broad interests. In the tradition of Cannon and his broad interests, we discuss our laboratory's multi-faceted work in signal transduction over the past 40+ years. We show how our questioning of how growth hormone (GH) in the blood communicates with cells throughout the body to promote body growth and regulate body metabolism led to insight into not only body height, but also important regulators of malignancy and body weight. High...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 6, 2023 Category: Physiology Authors: Christin Carter-Su Lawrence S Argetsinger Nadezhda V Svezhova Source Type: research
Bone marrow mesenchymal stem cell exosomal miR-345-3p ameliorates cerebral ischemia-reperfusion injury by targeting TRAF6
CONCLUSION: This study found that BMSCs-exosomal miR-345-3p protected against CIR injury by decreasing TRAF6.PMID:37670712 | DOI:10.2174/1567202620666230905121102
Source: Current Neurovascular Research - September 6, 2023 Category: Neurology Authors: Dan Hou Lei Zhang Yujie Hu Guoshuai Yang Dan Yu Source Type: research
2022 Cannon Lecture: An ode to signal transduction - how the growth hormone pathway revealed insight into height, malignancy and obesity
Am J Physiol Endocrinol Metab. 2023 Sep 6. doi: 10.1152/ajpendo.00265.2023. Online ahead of print.ABSTRACTWalter Cannon was a highly regarded American neurologist and physiologist with extremely broad interests. In the tradition of Cannon and his broad interests, we discuss our laboratory's multi-faceted work in signal transduction over the past 40+ years. We show how our questioning of how growth hormone (GH) in the blood communicates with cells throughout the body to promote body growth and regulate body metabolism led to insight into not only body height, but also important regulators of malignancy and body weight. High...
Source: Am J Physiol Endocri... - September 6, 2023 Category: Endocrinology Authors: Christin Carter-Su Lawrence S Argetsinger Nadezhda V Svezhova Source Type: research
Bone marrow mesenchymal stem cell exosomal miR-345-3p ameliorates cerebral ischemia-reperfusion injury by targeting TRAF6
CONCLUSION: This study found that BMSCs-exosomal miR-345-3p protected against CIR injury by decreasing TRAF6.PMID:37670712 | DOI:10.2174/1567202620666230905121102
Source: Current Neurovascular Research - September 6, 2023 Category: Neurology Authors: Dan Hou Lei Zhang Yujie Hu Guoshuai Yang Dan Yu Source Type: research
2022 Cannon Lecture: An ode to signal transduction - how the growth hormone pathway revealed insight into height, malignancy and obesity
Am J Physiol Endocrinol Metab. 2023 Sep 6. doi: 10.1152/ajpendo.00265.2023. Online ahead of print.ABSTRACTWalter Cannon was a highly regarded American neurologist and physiologist with extremely broad interests. In the tradition of Cannon and his broad interests, we discuss our laboratory's multi-faceted work in signal transduction over the past 40+ years. We show how our questioning of how growth hormone (GH) in the blood communicates with cells throughout the body to promote body growth and regulate body metabolism led to insight into not only body height, but also important regulators of malignancy and body weight. High...
Source: Am J Physiol Endocri... - September 6, 2023 Category: Endocrinology Authors: Christin Carter-Su Lawrence S Argetsinger Nadezhda V Svezhova Source Type: research
