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Nutrition: Potassium
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Total 1055 results found since Jan 2013.
Enhanced Contraction of Arterial Smooth Muscle Cell in Skin Artery Is Sensitive to Hyperpolarization Mediated by BK < sub > Ca < /sub > Channel in Chronic Constriction Injury Model Rat
In this study, we aimed to elucidate the mechanism underlying enhanced vasorelaxation induced by vasodilators, which increase cAMP and cyclic guanosine monophosphate (cGMP), in chronic constriction injury model rat. We assessed vasorelaxation effect of vasodilators by measurement of isometric contraction in isolated plantar artery from chronic constriction injury of sciatic nerve model rats. Nifedipine, a voltage-dependent Ca2+ channel inhibitor, NS1619, Ca2+-activated K+ (BKCa) channel opener, and diazoxide, an ATP-sensitive potassium channel opener, -induced vasorelaxation in ipsilateral plantar artery was enhanced compa...
Source: Biological and Pharmaceutical Bulletin - March 1, 2023 Category: Drugs & Pharmacology Authors: Hirotake Ishida Tomohisa Ishikawa Shin-Ya Saito Source Type: research
Systemic Effects of Perineural Glucocorticoids on Fasting Serum Glucose, Potassium, and White Blood Cell Count in Total Hip Arthroplasty
CONCLUSION: Patients who underwent THA and received PAI+PNB with glucocorticoid adjuvants demonstrated higher elevations in serum glucose for the first two PODs compared to patients who received PAI alone. These differences resolved by a third POD and are likely to be of no clinical significance.PMID:36846205 | PMC:PMC9946012 | DOI:10.2147/JPR.S395336
Source: Cell Research - February 27, 2023 Category: Cytology Authors: Avijit Sharma Feng Dai Lanya Tseng Philip R Effraim Bin Zhou Robert B Schonberger Jinlei Li Source Type: research
Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability
This study implicates Kv7.2/Kv7.3 channels as effective modulators of sensory neuron excitability, and suggest that compounds that specifically target Kv7.2/Kv7.3 currents in sensory neurons, including human sensory neurons, might provide an effective approach toward pain relief.
Source: Frontiers in Pharmacology - February 27, 2023 Category: Drugs & Pharmacology Source Type: research
Systemic Effects of Perineural Glucocorticoids on Fasting Serum Glucose, Potassium, and White Blood Cell Count in Total Hip Arthroplasty
Source: Journal of Pain Research - February 17, 2023 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
Flupirtine and antihistamines exert synergistic anti-nociceptive effects in mice
ConclusionsFlupirtine and antihistamines produced synergistic analgesic effects in all the above pain models. The analgesic effects of antihistamines were partially mediated by Kv7/M channels, and the activation of Kv7/M channels may be partly responsible for the synergistic analgesic effects between flupirtine and antihistamines.
Source: Psychopharmacology - February 8, 2023 Category: Psychiatry Source Type: research
The nociceptive response induced by different classes of < i > Tityus serrulatus < /i > neurotoxins: The important role of Ts5 in venom-induced nociception
by Felipe Cerni, Isadora Oliveira, Francielle Cordeiro, Karla Bordon, Isabela Ferreira, Wuelton Monteiro, Eliane Arantes, Thiago Cunha, Manuela Pucca
Scorpion sting envenomations (SSE) are feared by the intense pain that they produce in victims. Pain from SSE is triggered mainly by the presence of neurotoxins in the scorpion venom that modulates voltage-gated ion channels. In Brazil, SSE is mostly caused byTityus serrulatus, popularly known as yellow scorpion. Here, we evaluated experimental spontaneous nociception induced byT.serrulatus venom as well as its isolated neurotoxins Ts1, Ts5, Ts6, Ts8, and Ts19 frag II, evide...
Source: PLoS Neglected Tropical Diseases - January 30, 2023 Category: Tropical Medicine Authors: Felipe Cerni Source Type: research
A Novel Approach for the Availability and Ocular Delivery of Tenoxicam Potassium: Synthesis, Characterization, and In Vivo Application
This study aims to improve TX solubility by converting it into its potassium salt to achieve a target of 10 mg/mL (1%w/v) concentration of TX in the desired aqueous medium for the formulation of aqueous ophthalmic solutions. The synthesized TX salt was characterized by different evaluation parameters such as solubility studies, 1H NMR, IR, and elemental analyses. Different TX potassium solutions were formulated at concentrations of 0.5% and 1% w/v using different viscosity-imparting agents. The prepared solutions were characterized for their physicochemical properties including visual inspection, pH, rheological, in vitro ...
Source: AAPS PharmSciTech - January 26, 2023 Category: Drugs & Pharmacology Authors: Shaaban K Osman Taher M Yassin Ahmed M Mohammed Abdallah M Alfayomy Ahmed A Abdellatif Wael A Mahdi Sultan Alshehri Mohamed A El Hamd Hatem Sarhan Mohammed A Ibrahim Source Type: research
An intelligent intestinal bleeding diagnosis and treatment capsule system based on color recognition
Biomed Microdevices. 2023 Jan 25;25(1):6. doi: 10.1007/s10544-022-00642-y.ABSTRACTTo our best knowledge, there are no non-invasive and painless means for the diagnosis and treatment of intestinal bleeding as of now, especially the segment of intestine that cannot be reached by endoscopy. We proposed an intelligent intestinal bleeding diagnosis and treatment capsule (IBDTC) system for the first time to diagnose and treat intestinal bleeding with low power consumption, estimated to be about 2.16mW. A hue-saturation-light (HSL) color space method was applied to diagnose bleeding according to H (hue) values of the film dyed by...
Source: Biomedical Microdevices - January 25, 2023 Category: Biomedical Engineering Authors: Panpan Qiao Luo Yu Hongying Liu Xueping Yan Xitian Pi Source Type: research
