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Unique Case of Cardiomyopathy Secondary to Adrenal Adenoma (Primary-Aldosteronism)
CONCLUSION: Prior in-vitro studies suggested possible aldosterone (excess) induced direct activation of mineralocorticoid receptors in (low-density/serum-free) ventricular myocytes (culture); also aldosterone increases mRNA for cardiac-ANF & alpha/beta-myosin heavy-chains (aldosterone also effects collagen deposition & fibroblast proliferation). All of these were clearly prevented by adding spironolactone. References Higuchi S, Ota H, Tezuka Y, et al. Aldosterone-induced cardiac damage in primary aldosteronism depends on its subtypes, Endocr Connect 2021;10(1):29-36. Petramala L, Concistrè A, Olmati F, et ...
Source: Journal of the Association of Physicians of India - April 28, 2023 Category: General Medicine Authors: Chirantan Mandal Pradeep Kumar Dutta Source Type: research
