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Total 34 results found since Jan 2013.

Activation of the Aryl Hydrocarbon Receptor in Muscle Exacerbates Ischemic Pathology in Chronic Kidney Disease
CONCLUSIONS: These findings establish AHR activation in muscle as a pivotal regulator of the ischemic limb pathology in CKD. Further, the totality of the results provides support for testing of clinical interventions that diminish AHR signaling in these conditions.PMID:37325935 | DOI:10.1161/CIRCRESAHA.123.322875
Source: Circulation Research - June 16, 2023 Category: Cardiology Authors: Nicholas Balestrieri Victoria Palzkill Caroline Pass Jianna Tan Zachary R Salyers Chatick Moparthy Ania Murillo Kyoungrae Kim Trace Thome Qingping Yang Kerri A O'Malley Scott A Berceli Feng Yue Salvatore T Scali Leonardo F Ferreira Terence E Ryan Source Type: research

Chronic activation of the aryl hydrocarbon receptor in muscle exacerbates ischemic pathology in chronic kidney disease
bioRxiv. 2023 May 18:2023.05.16.541060. doi: 10.1101/2023.05.16.541060. Preprint.ABSTRACTChronic kidney disease (CKD) accelerates the development of atherosclerosis, decreases muscle function, and increases the risk of amputation or death in patients with peripheral artery disease (PAD). However, the cellular and physiological mechanisms underlying this pathobiology are ill-defined. Recent work has indicated that tryptophan-derived uremic toxins, many of which are ligands for the aryl hydrocarbon receptor (AHR), are associated with adverse limb outcomes in PAD. We hypothesized that chronic AHR activation, driven by the acc...
Source: Atherosclerosis - June 9, 2023 Category: Cardiology Authors: Nicholas Balestrieri Victoria Palzkill Caroline Pass Jianna Tan Zachary R Salyers Chatick Moparthy Ania Murillo Kyoungrae Kim Trace Thome Qingping Yang Kerri A O'Malley Scott A Berceli Feng Yue Salvatore T Scali Leonardo F Ferreira Terence E Ryan Source Type: research

Quantitative assessment of left ventricular myocardial involvement in patients with connective tissue disease: a 3.0T contrast-enhanced cardiovascular magnetic resonance study
This study indicated that CTD patients showed impaired LV global myocardial deformation and m icrovascular perfusion, and presence of LGE. Cardiac involvement might be more severe in non-IIM patients than in IIM patients. Impaired microvascular perfusion and the presence of LGE were independently associated with LV global deformation.
Source: The International Journal of Cardiovascular Imaging - March 13, 2022 Category: Radiology Source Type: research

Muscle-Skeletal Abnormalities and Muscle Oxygenation during Isokinetic Strength Exercise in Heart Failure with Preserved Ejection Fraction Phenotype: A Cross-Sectional Study
Int J Environ Res Public Health. 2022 Jan 9;19(2):709. doi: 10.3390/ijerph19020709.ABSTRACTExercise intolerance, a hallmark of patients with heart failure (HF), is associated with muscle weakness. However, its causative microcirculatory and muscle characteristics among those with preserved or reduced ejection fraction (HFpEF or HFrEF) phenotype is unclear. The musculoskeletal abnormalities that could result in impaired peripheral microcirculation are sarcopenia and muscle strength reduction in HF, implying lowered oxidative capacity and perfusion affect transport and oxygen utilization during exercise, an essential task fr...
Source: Biomed Res - January 21, 2022 Category: Research Authors: Amanda Vale-Lira Nat ália Turri-Silva Kenneth Verboven Jo ão Luiz Quagliotti Durigan Alexandra Corr êa G B de Lima Martim Bottaro Gaspar R Chiappa Dominique Hansen Gerson Cipriano Source Type: research

A Swine Hind Limb Ischemia Model Useful for Testing Peripheral Artery Disease Therapeutics
AbstractCurrently, there is no large animal model of sustained limb ischemia suitable for testing novel angiogenic therapeutics for peripheral artery disease (PAD) such as drugs, genes, materials, or cells. We created a large animal model suitable for efficacy assessment of these therapies by testing 3 swine hind limb ischemia (HLI) variations and quantifying vascular perfusion, muscle histology, and limb function. Ligation of the ipsilateral external and bilateral internal iliac arteries produced sustained gait dysfunction compared to isolated external iliac or unilateral external and internal iliac artery ligations. Hype...
Source: Journal of Cardiovascular Translational Research - December 1, 2021 Category: Cardiology Source Type: research

Mechanism of Hydrogen Sulfide Preconditioning-Associated Protection Against Ischemia-Reperfusion Injury Differs in Diabetic Heart That Develops Myopathy.
Abstract Hydrogen sulfide (H2S) is reported to be effective in the management of the myocardial ischemia-reperfusion (I/R) injury via PI3K/GSK3β pathway in normal rats. However, its efficacy against I/R in the presence of diabetic cardiomyopathy is relatively obscure. Thus, the present work aimed to find out H2S-mediated cardioprotection against I/R in diabetic cardiomyopathy and to evaluate its mode of action using Langendorff isolated heart perfusion system. The present work includes three groups of rat, viz. (i) normal, (ii) diabetes mellitus (DM: streptozotocin: 35 mg/kg; normal diet), and (iii) diabetes +...
Source: Cardiovascular Toxicology - July 16, 2019 Category: Cardiology Authors: Ansari M, Kurian GA Tags: Cardiovasc Toxicol Source Type: research

Temporal Association Between Ischemic Muscle Perfusion Recovery and the Restoration of Muscle Contractile Function After Hindlimb Ischemia
We examined this relationship in BALB/cJ mice (N=24) following unilateral hindlimb ischemia (HLI). Specifically, we examined this relationship in two phenotypically distinct muscles (i.e. ‘oxidative’ soleus - Sol and ‘glycolytic’ extensor digitorum longus - EDL) 14- or 56-days after HLI. Although overall limb blood flow (LDPI) reached its’ recovery peak (48% of control) by HLI d14, the capillary networks in both the Sol and EDL (whole mount confocal imaging) were disrupted and competent muscle capillary perfusion (perfused lectin+ μm2 / muscle μm2) remained reduced. Interestingly, both Sol and EDL muscles recov...
Source: Frontiers in Physiology - June 27, 2019 Category: Physiology Source Type: research